Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Sharadrao M. Patil"'
Autor:
Deyun Wang, You Zhuo, Mike Karfunkle, Sharadrao M. Patil, Cameron J. Smith, David A. Keire, Kang Chen
Publikováno v:
Molecules, Vol 26, Iss 14, p 4251 (2021)
Peptide and protein drug molecules fold into higher order structures (HOS) in formulation and these folded structures are often critical for drug efficacy and safety. Generic or biosimilar drug products (DPs) need to show similar HOS to the reference
Externí odkaz:
https://doaj.org/article/0e8386945d20489ea9b1a4234113e6b6
Publikováno v:
Journal of Diabetes Research, Vol 2015 (2015)
To test the hypothesis that electrostatic repulsion is an important force opposing amyloid fibril assembly, we designed peptides that substitute strings of positively or negatively charged residues into the sequence of the amyloidogenic hormone amyli
Externí odkaz:
https://doaj.org/article/6b28083b3cbd46f097dfffa7c6c2e254
Autor:
Kang Chen, Meiyu Shen, Cyrus Agarabi, Meng-Jung Chiang, Patrick Lynch, Weiming Ouyang, Faruk Sheikh, Sharadrao M. Patil, Ankit B. Shah, Raymond P. Donnelly, Kurt Brorson, Hui Fang, Sarah Rogstad, Phillip Angart, David M. Frucht, Sarah J. Schrieber, Ashwinkumar A. Bhirde, Tao Xie, Kristina E. Howard
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
PEGylated recombinant human granulocyte colony stimulating factor (pegfilgrastim) is used clinically to accelerate immune reconstitution following chemotherapy and is being pursued for biosimilar development. One challenge to overcome in pegfilgrasti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe45b4fa2041b60abacd838f0477ced2
http://link.springer.com/article/10.1038/s41598-020-59346-z
http://link.springer.com/article/10.1038/s41598-020-59346-z
Autor:
David A. Keire, Snober Ahmed, Xiaohui Jiang, Yan Wang, Kang Chen, Sharadrao M. Patil, Bin Qin, Huzeyfe Yilmaz
Publikováno v:
AAPS PharmSciTech. 22
Degarelix is a gonadotropin-releasing hormone (GnRH) receptor antagonist. Upon contact with physiological fluid, degarelix undergoes quick gelation and forms a depot at the site of injection providing sustained release. The molecular gelling kinetics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c123bb61927fc4d1ec2b6c8db651f98
https://doi.org/10.1208/s12249-021-01948-5
https://doi.org/10.1208/s12249-021-01948-5
Publikováno v:
Pharmaceutical Research. 37
Analytical methods suitable for intact drug products are often necessary to evaluate the equivalence in physicochemical properties between two drug products (DP) containing the same drug substance (DS), e.g., an innovator biologic drug and its propos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd47e4e60c8d6e6affbadd620afccb26
https://doi.org/10.1007/s11095-020-02961-2
https://doi.org/10.1007/s11095-020-02961-2
Autor:
Kang Chen, Jason D. Rodriguez, Stephanie Choi, Min Sung Suh, Xiaohui Jiang, Eric Pang, Darby Kozak, David A. Keire, Sharadrao M. Patil
Publikováno v:
AAPS PharmSciTech. 21
The paclitaxel protein-bound particles for injectable suspension (marketed under the brand name Abraxane®) contains nanosized complexes of paclitaxel and albumin. The molecular interaction between paclitaxel and albumin within the higher-order nanos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b428836268b44edfc04e0974785077d2
https://doi.org/10.1208/s12249-020-01669-1
https://doi.org/10.1208/s12249-020-01669-1
Publikováno v:
AAPS PharmSciTech. 19:1647-1651
Generic drug products are expected to have the same active pharmaceutical ingredient (API) (Q1) with the same content (Q2) and microstructure arrangement (Q3) as the innovator product. In complex oil-in-water emulsion drugs, the hydrophobic API is ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14a4b3743263a6283b0ae641eaa9a006
https://doi.org/10.1208/s12249-018-0973-8
https://doi.org/10.1208/s12249-018-0973-8
Autor:
Cameron J. Smith, David A. Keire, John L. Leazer, Sharadrao M. Patil, Kang Chen, Deyun Wang, Junyong Park
Publikováno v:
Journal of pharmaceutical sciences. 109(4)
Protein or peptide higher order structure (HOS) is a quality attribute that could affect therapeutic efficacy and safety. Where appropriate, the HOS similarity between a proposed follow-on product and the reference listed drug should be demonstrated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f6b7b8d5bccd50ec1aaefe6c5a0c14c
https://pubmed.ncbi.nlm.nih.gov/31927041
https://pubmed.ncbi.nlm.nih.gov/31927041
Autor:
Darby Kozak, Jin Xu, David A. Keire, Jiangnan Peng, Vincent Li, Bing Cai, Kang Chen, Sharadrao M. Patil
In a typical oil-in-water emulsion drug product, oil droplets with varied sizes are dispersed in a water phase and stabilized by surfactant molecules. The size and polydispersity of oil droplets are critical quality attributes of the emulsion drug pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e9069b5898114b589bb47a4e991ccdd
https://europepmc.org/articles/PMC6995278/
https://europepmc.org/articles/PMC6995278/
Glycosylation of monoclonal antibodies (mAbs) is a critical quality attribute that can impact mAb drug efficacy and safety. The mAb glycans are inherently heterogeneous in chemical structure and composition of monosaccharides. The established fluores
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7105369a8e03bf7eda9ac81fb0be36b
https://europepmc.org/articles/PMC7040853/
https://europepmc.org/articles/PMC7040853/