Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Sharada Jagannathan"'
Autor:
Zhongren J. Wu, Daniel M. Camac, Peter J. Domaille, Zelda R. Wasserman, Sharon J. Archer, Lawrence J. Mersinger, Charles A. Kettner, Christopher J. Rizzo, Marina Bukhtiyarova, Sharada Jagannathan, Neil A. Farrow
Publikováno v:
Chemistry & Biology. 9(1):79-92
NMR spectroscopy was used to characterize the hepatitis C virus (HCV) NS3 protease in a complex with the 24 residue peptide cofactor from NS4A and a boronic acid inhibitor, Ac-Asp-Glu-Val-Val-Pro-boroAlg-OH. Secondary-structure information, NOE const
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::980d55bc9e3375bba9449a162ee65ea3
Synthesis of boronic acid analogues of alpha-amino acids by introducing side chains as electrophiles
Publikováno v:
The Journal of organic chemistry. 66(19)
A synthetic route has been developed which has allowed us to prepare novel alpha-aminoboronic acids as inhibitors of serine proteases. These compounds were prepared to study the roles of proteases in biological systems. This methodology affords alpha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f25a17799717af3b3067f5df3279b43e
https://pubmed.ncbi.nlm.nih.gov/11559189
https://pubmed.ncbi.nlm.nih.gov/11559189
Publikováno v:
Steroids. 63(4)
The synthesis of 17-oxoandrosta-3,5-dien-3-methyl sulfonate 3, a stable analog of memory-enhancing neurosteroid dehydroepiandrosterone sulfate, is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25e316285e9bc6be067b937e658e81a7
https://pubmed.ncbi.nlm.nih.gov/9589556
https://pubmed.ncbi.nlm.nih.gov/9589556
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 59(1)
Estrogen levels in breast tumors of post-menopausal women are as much as 10 times higher than in plasma, presumably due to in situ formation of estrogen. Several lines of evidence indicate that the major source of estrogen in breast cancer cells may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1759c4da8b0f7d5bdd6cb3704861470
https://pubmed.ncbi.nlm.nih.gov/9009241
https://pubmed.ncbi.nlm.nih.gov/9009241
Publikováno v:
Brain research. Cognitive brain research. 2(4)
The intent of the study was to determine whether altering the metabolism of neurosteroids via blockade of the enzyme, steroid sulfatase, could enhance retention test performance in rats. The steroid sulfatase inhibitor estrone-3-O-sulfamate (EMATE) w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5147c1699fcf211ba0fc6b0a0580be9d
https://pubmed.ncbi.nlm.nih.gov/8580738
https://pubmed.ncbi.nlm.nih.gov/8580738