Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Sharad Khare"'
Autor:
Alexei J. Stuckel, Shuai Zeng, Zhen Lyu, Wei Zhang, Xu Zhang, Urszula Dougherty, Reba Mustafi, Tripti Khare, Qiong Zhang, Trupti Joshi, Marc Bissonnette, Sharad Khare
Publikováno v:
Epigenetics, Vol 18, Iss 1 (2023)
Sprouty4 (SPRY4) has been frequently reported as a tumor suppressor and is therefore downregulated in various cancers. For the first time, we report that SPRY4 is epigenetically upregulated in colorectal cancer (CRC). In this study, we explored DNA m
Externí odkaz:
https://doaj.org/article/01f8717e29a94b0eaa5128dbd992adb5
Publikováno v:
Epigenetics, Vol 17, Iss 13, Pp 2318-2331 (2022)
CXCR4 is involved in many facets of cancer, including being a major player in establishing metastasis. This is in part due to the deregulation of CXCR4, which can be attributed to many genetic and epigenetic mechanisms, including aberrant microRNA–
Externí odkaz:
https://doaj.org/article/ee2dbae64af94adf8ad00e06d8e14eb6
Publikováno v:
Biomolecules, Vol 12, Iss 5, p 645 (2022)
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. HCC is diagnosed in its advanced stage when limited treatment options are available. Substantial morphologic, genetic and epigenetic heterogeneity has been
Externí odkaz:
https://doaj.org/article/05272bcf6fde430fa2826b9eab08ba97
Autor:
Alexei J. Stuckel, Shuai Zeng, Zhen Lyu, Wei Zhang, Xu Zhang, Urszula Dougherty, Reba Mustafi, Qiong Zhang, Trupti Joshi, Marc Bissonnette, Samrat Roy Choudhury, Sharad Khare
Publikováno v:
Cells, Vol 10, Iss 10, p 2632 (2021)
Conventional wisdom is that Sprouty2 (SPRY2), a suppressor of Receptor Tyrosine Kinase (RTK) signaling, functions as a tumor suppressor and is downregulated in many solid tumors. We reported, for the first time, that increased expression of SPRY2 aug
Externí odkaz:
https://doaj.org/article/7fdf92d5c6ff403b94cd6780e8fa8c7c
CXCL12-CXCR4/CXCR7 Axis in Colorectal Cancer: Therapeutic Target in Preclinical and Clinical Studies
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 14, p 7371 (2021)
Chemokines are chemotactic cytokines that promote cancer growth, metastasis, and regulate resistance to chemotherapy. Stromal cell-derived factor 1 (SDF1) also known as C-X-C motif chemokine 12 (CXCL12), a prognostic factor, is an extracellular homeo
Externí odkaz:
https://doaj.org/article/dbc3554598964f7c95d83b611cc5eb35
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 11, p 3956 (2020)
Many synthetic drugs and monoclonal antibodies are currently in use to treat Inflammatory Bowel Disease (IBD). However, they all are implicated in causing severe side effects and long-term use results in many complications. Numerous in vitro and in v
Externí odkaz:
https://doaj.org/article/d610d4f9ceab47aba4e098488d76a430
Autor:
Marc Bissonnette, Yan Chun Li, Gregory S. Karczmar, Alice Wyrwicz, Loren Joseph, John Hart, Sharad Khare, Joel Pekow, Vani J. Konda, Weicheng Liu, Sumana Sundaramurthy, Maggi Kreisheh, Devkumar Mustafi, Anas Almoghrabi, Farhana Sadiq, Reba Mustafi, Urszula Dougherty
Supplemental Methods and Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::744b5f43f2546273ada2dbf23240f51c
https://doi.org/10.1158/1078-0432.22456941.v1
https://doi.org/10.1158/1078-0432.22456941.v1
Autor:
Marc Bissonnette, Yan Chun Li, Gregory S. Karczmar, Alice Wyrwicz, Loren Joseph, John Hart, Sharad Khare, Joel Pekow, Vani J. Konda, Weicheng Liu, Sumana Sundaramurthy, Maggi Kreisheh, Devkumar Mustafi, Anas Almoghrabi, Farhana Sadiq, Reba Mustafi, Urszula Dougherty
Supplemental Figure S2. EGF induces Snail in HT29 colon cancer cells. Cells were plated on collagen-coated 6 well plates in 10% serum. Twenty-four hrs later cells were deprived of serum and treated with vehicle (phosphate-buffered saline), 10 ng/ml E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa294947b0157a508f656817dc84311
https://doi.org/10.1158/1078-0432.22456950.v1
https://doi.org/10.1158/1078-0432.22456950.v1
Autor:
Marc Bissonnette, Yan Chun Li, Gregory S. Karczmar, Alice Wyrwicz, Loren Joseph, John Hart, Sharad Khare, Joel Pekow, Vani J. Konda, Weicheng Liu, Sumana Sundaramurthy, Maggi Kreisheh, Devkumar Mustafi, Anas Almoghrabi, Farhana Sadiq, Reba Mustafi, Urszula Dougherty
Purpose: We previously showed that EGF receptor (EGFR) promotes tumorigenesis in the azoxymethane/dextran sulfate sodium (AOM/DSS) model, whereas vitamin D suppresses tumorigenesis. EGFR–vitamin D receptor (VDR) interactions, however, are incomplet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b52db3d839775080e2e485007f9dea
https://doi.org/10.1158/1078-0432.c.6523464.v1
https://doi.org/10.1158/1078-0432.c.6523464.v1
Autor:
Marc Bissonnette, Robert Carroll, Gerry R. Boss, Alessandro Fichera, Frank A. Sinicrope, Sharad Khare, Piotr Obara, Weihua Yuan, Maria Tretiakova, Lisa Yerian, John Hart, Loren Joseph, Urszula Dougherty, Sujatha Jagadeeswaran, Sonia Cerda, Jeff Nathanson, Nathaniel Little, Anusara Chumsangsri, Reba Mustafi, Greg Cohen
Supplementary Tables S1 & S2 from Epidermal Growth Factor Receptor Signaling Is Up-regulated in Human Colonic Aberrant Crypt Foci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c24996feb018c482eefdd34b5aead64
https://doi.org/10.1158/0008-5472.22365020.v1
https://doi.org/10.1158/0008-5472.22365020.v1