Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Sharad K Verma"'
Autor:
Salvatore La Rosa, Vidya Browder, Annette C Bakker, Jaishri O Blakeley, Sharad K Verma, Ling M Wong, Jill Morris, Naba Bora
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 1, Pp 1-6 (2019)
Abstract The time from identifying a drug target to a new drug approval is often measured in decades and can take even longer for therapies to treat rare diseases. In fact, 95% of rare diseases do not have a specific therapy approved at all. Coordina
Externí odkaz:
https://doaj.org/article/ac0f85391a4b48ffaa21221cfe7ef4e9
Autor:
Michael T. McCabe, Caretha L. Creasy, Peter J. Tummino, Benjamin Schwartz, Dashyant Dhanak, Ryan G. Kruger, Steven D. Knight, Sharad K. Verma, Roland Annan, Yuchen Bai, Yong Jiang, Edward Dul, Arthur Groy, Ashley M. Hughes, Wendy S. Halsey, Michael Huddleston, Melissa B. Pappalardi, Alan P. Graves, Heidi M. Ott
Supplementary Figure 1: Standard curves of recombinant modified histone proteins for quantification of western blots
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0b70fab24cd9253c9bdf762690f23cd
https://doi.org/10.1158/1535-7163.22502863
https://doi.org/10.1158/1535-7163.22502863
Autor:
Michael T. McCabe, Caretha L. Creasy, Peter J. Tummino, Benjamin Schwartz, Dashyant Dhanak, Ryan G. Kruger, Steven D. Knight, Sharad K. Verma, Roland Annan, Yuchen Bai, Yong Jiang, Edward Dul, Arthur Groy, Ashley M. Hughes, Wendy S. Halsey, Michael Huddleston, Melissa B. Pappalardi, Alan P. Graves, Heidi M. Ott
Supplementary Figure 5: H3K27me3 enrichment across genes modulated by EZH2 inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17cbce9f297e14e12c2f127057abaa64
https://doi.org/10.1158/1535-7163.22502851
https://doi.org/10.1158/1535-7163.22502851
Autor:
Michael T. McCabe, Caretha L. Creasy, Peter J. Tummino, Benjamin Schwartz, Dashyant Dhanak, Ryan G. Kruger, Steven D. Knight, Sharad K. Verma, Roland Annan, Yuchen Bai, Yong Jiang, Edward Dul, Arthur Groy, Ashley M. Hughes, Wendy S. Halsey, Michael Huddleston, Melissa B. Pappalardi, Alan P. Graves, Heidi M. Ott
Supplementary Figure 6: Gene Set Enrichment Analysis (GSEA) for SUP-B8 cells treated with GSK126
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29878da08c2c656b4737c8a9f2569af8
https://doi.org/10.1158/1535-7163.22502848
https://doi.org/10.1158/1535-7163.22502848
Autor:
Michael T. McCabe, Caretha L. Creasy, Peter J. Tummino, Benjamin Schwartz, Dashyant Dhanak, Ryan G. Kruger, Steven D. Knight, Sharad K. Verma, Roland Annan, Yuchen Bai, Yong Jiang, Edward Dul, Arthur Groy, Ashley M. Hughes, Wendy S. Halsey, Michael Huddleston, Melissa B. Pappalardi, Alan P. Graves, Heidi M. Ott
Supplementary Table 2: Biochemical activity of WT and A687V EZH2 complexes with modified histone peptides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd06bae6a7a5cc40c0127e27ca12e945
https://doi.org/10.1158/1535-7163.22502836
https://doi.org/10.1158/1535-7163.22502836
Autor:
Michael T. McCabe, Caretha L. Creasy, Peter J. Tummino, Benjamin Schwartz, Dashyant Dhanak, Ryan G. Kruger, Steven D. Knight, Sharad K. Verma, Roland Annan, Yuchen Bai, Yong Jiang, Edward Dul, Arthur Groy, Ashley M. Hughes, Wendy S. Halsey, Michael Huddleston, Melissa B. Pappalardi, Alan P. Graves, Heidi M. Ott
Supplementary Figure 2: Alignment of all human SET domain methyltransferases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60b5b36a6ff87cbdd05ec3f4af86117f
https://doi.org/10.1158/1535-7163.22502860.v1
https://doi.org/10.1158/1535-7163.22502860.v1
Autor:
Michael T. McCabe, Caretha L. Creasy, Peter J. Tummino, Benjamin Schwartz, Dashyant Dhanak, Ryan G. Kruger, Steven D. Knight, Sharad K. Verma, Roland Annan, Yuchen Bai, Yong Jiang, Edward Dul, Arthur Groy, Ashley M. Hughes, Wendy S. Halsey, Michael Huddleston, Melissa B. Pappalardi, Alan P. Graves, Heidi M. Ott
Supplementary Table 1: Primers utilized for A687V EZH2 mutagenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0868605ccec1136c9c66b91477f87bc
https://doi.org/10.1158/1535-7163.22502839
https://doi.org/10.1158/1535-7163.22502839
Autor:
Michael T. McCabe, Caretha L. Creasy, Peter J. Tummino, Benjamin Schwartz, Dashyant Dhanak, Ryan G. Kruger, Steven D. Knight, Sharad K. Verma, Roland Annan, Yuchen Bai, Yong Jiang, Edward Dul, Arthur Groy, Ashley M. Hughes, Wendy S. Halsey, Michael Huddleston, Melissa B. Pappalardi, Alan P. Graves, Heidi M. Ott
Supplementary Table 3: Functional analysis of genes significantly up- and down-regulated in SUP-B8 and NALM-6 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d050dace88ef87e88c9c2a84f83ec4e
https://doi.org/10.1158/1535-7163.22502833.v1
https://doi.org/10.1158/1535-7163.22502833.v1
Autor:
Michael T. McCabe, Caretha L. Creasy, Peter J. Tummino, Benjamin Schwartz, Dashyant Dhanak, Ryan G. Kruger, Steven D. Knight, Sharad K. Verma, Roland Annan, Yuchen Bai, Yong Jiang, Edward Dul, Arthur Groy, Ashley M. Hughes, Wendy S. Halsey, Michael Huddleston, Melissa B. Pappalardi, Alan P. Graves, Heidi M. Ott
Supplementary Figure 4: Sanger sequencing chromatograms of EZH2 mutations in acute lymphoblastic leukemia cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c2f2f56e480e9b77077d961f1f98b2
https://doi.org/10.1158/1535-7163.22502854.v1
https://doi.org/10.1158/1535-7163.22502854.v1
Autor:
Annette Bakker, Justin Guinney, Sharad K. Verma, Sara J. C. Gosline, Salvatore La Rosa, Jaishri O. Blakeley, Robert J. Allaway, Lara M. Mangravite
Publikováno v:
Scientific Data, Vol 6, Iss 1, Pp 1-4 (2019)
Scientific Data
Scientific Data
A significant challenge facing rare disease communities is finding a sufficient quantity and variety of data to develop and test disease-specific hypotheses. Here we describe an approach to data sharing in which stakeholders from the neurofibromatosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d0809501b96cf81ac074447a1fb48b
http://link.springer.com/article/10.1038/s41597-019-0317-x
http://link.springer.com/article/10.1038/s41597-019-0317-x