Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Sharad, Khare"'
Autor:
Alexei J. Stuckel, Shuai Zeng, Zhen Lyu, Wei Zhang, Xu Zhang, Urszula Dougherty, Reba Mustafi, Tripti Khare, Qiong Zhang, Trupti Joshi, Marc Bissonnette, Sharad Khare
Publikováno v:
Epigenetics, Vol 18, Iss 1 (2023)
Sprouty4 (SPRY4) has been frequently reported as a tumor suppressor and is therefore downregulated in various cancers. For the first time, we report that SPRY4 is epigenetically upregulated in colorectal cancer (CRC). In this study, we explored DNA m
Externí odkaz:
https://doaj.org/article/01f8717e29a94b0eaa5128dbd992adb5
Publikováno v:
Epigenetics, Vol 17, Iss 13, Pp 2318-2331 (2022)
CXCR4 is involved in many facets of cancer, including being a major player in establishing metastasis. This is in part due to the deregulation of CXCR4, which can be attributed to many genetic and epigenetic mechanisms, including aberrant microRNA–
Externí odkaz:
https://doaj.org/article/ee2dbae64af94adf8ad00e06d8e14eb6
Publikováno v:
Biomolecules, Vol 12, Iss 5, p 645 (2022)
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. HCC is diagnosed in its advanced stage when limited treatment options are available. Substantial morphologic, genetic and epigenetic heterogeneity has been
Externí odkaz:
https://doaj.org/article/05272bcf6fde430fa2826b9eab08ba97
Autor:
Alexei J. Stuckel, Shuai Zeng, Zhen Lyu, Wei Zhang, Xu Zhang, Urszula Dougherty, Reba Mustafi, Qiong Zhang, Trupti Joshi, Marc Bissonnette, Samrat Roy Choudhury, Sharad Khare
Publikováno v:
Cells, Vol 10, Iss 10, p 2632 (2021)
Conventional wisdom is that Sprouty2 (SPRY2), a suppressor of Receptor Tyrosine Kinase (RTK) signaling, functions as a tumor suppressor and is downregulated in many solid tumors. We reported, for the first time, that increased expression of SPRY2 aug
Externí odkaz:
https://doaj.org/article/7fdf92d5c6ff403b94cd6780e8fa8c7c
Autor:
Marc Bissonnette, Yan Chun Li, Gregory S. Karczmar, Alice Wyrwicz, Loren Joseph, John Hart, Sharad Khare, Joel Pekow, Vani J. Konda, Weicheng Liu, Sumana Sundaramurthy, Maggi Kreisheh, Devkumar Mustafi, Anas Almoghrabi, Farhana Sadiq, Reba Mustafi, Urszula Dougherty
Supplemental Figure S1. Tarceva, an EGFR inhibitor, blocks Ang II induced HT29 cell proliferation. Cells (5,000) were plated on 96 well plates and allowed to adhere overnight. Cells were then treated with Tarceva (10 µM), or vehicle for 2 hrs foll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0597fd1c744f6a794cccb447c280b79b
https://doi.org/10.1158/1078-0432.22456953
https://doi.org/10.1158/1078-0432.22456953
Autor:
Marc Bissonnette, Yan Chun Li, Gregory S. Karczmar, Alice Wyrwicz, Loren Joseph, John Hart, Sharad Khare, Joel Pekow, Vani J. Konda, Weicheng Liu, Sumana Sundaramurthy, Maggi Kreisheh, Devkumar Mustafi, Anas Almoghrabi, Farhana Sadiq, Reba Mustafi, Urszula Dougherty
Supplemental Methods and Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::744b5f43f2546273ada2dbf23240f51c
https://doi.org/10.1158/1078-0432.22456941.v1
https://doi.org/10.1158/1078-0432.22456941.v1
Autor:
Marc Bissonnette, Yan Chun Li, Gregory S. Karczmar, Alice Wyrwicz, Loren Joseph, John Hart, Sharad Khare, Joel Pekow, Vani J. Konda, Weicheng Liu, Sumana Sundaramurthy, Maggi Kreisheh, Devkumar Mustafi, Anas Almoghrabi, Farhana Sadiq, Reba Mustafi, Urszula Dougherty
Purpose: We previously showed that EGF receptor (EGFR) promotes tumorigenesis in the azoxymethane/dextran sulfate sodium (AOM/DSS) model, whereas vitamin D suppresses tumorigenesis. EGFR–vitamin D receptor (VDR) interactions, however, are incomplet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b52db3d839775080e2e485007f9dea
https://doi.org/10.1158/1078-0432.c.6523464.v1
https://doi.org/10.1158/1078-0432.c.6523464.v1
Autor:
Marc Bissonnette, Robert Carroll, Gerry R. Boss, Alessandro Fichera, Frank A. Sinicrope, Sharad Khare, Piotr Obara, Weihua Yuan, Maria Tretiakova, Lisa Yerian, John Hart, Loren Joseph, Urszula Dougherty, Sujatha Jagadeeswaran, Sonia Cerda, Jeff Nathanson, Nathaniel Little, Anusara Chumsangsri, Reba Mustafi, Greg Cohen
Supplementary Tables S1 & S2 from Epidermal Growth Factor Receptor Signaling Is Up-regulated in Human Colonic Aberrant Crypt Foci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c24996feb018c482eefdd34b5aead64
https://doi.org/10.1158/0008-5472.22365020.v1
https://doi.org/10.1158/0008-5472.22365020.v1
Autor:
Marc Bissonnette, Jerrold R. Turner, John Hart, Loren Joseph, Greg Cohen, Michael Tallerico, Can Gong, Maria Tretiakova, Sharad Khare, Weihua Yuan, Sonia Cerda, Reba Mustafi, Amikar Sehdev, Urszula Dougherty, Sujatha Jagadeeswaran, Nathaniel Little, Alessandro Fichera
Supplementary Figure 1 from Epidermal Growth Factor Receptor Signaling Is Required for Microadenoma Formation in the Mouse Azoxymethane Model of Colonic Carcinogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d6652692bed1bfc006bc247e57831e4
https://doi.org/10.1158/0008-5472.22367111
https://doi.org/10.1158/0008-5472.22367111
Autor:
Marc Bissonnette, Robert Carroll, Gerry R. Boss, Alessandro Fichera, Frank A. Sinicrope, Sharad Khare, Piotr Obara, Weihua Yuan, Maria Tretiakova, Lisa Yerian, John Hart, Loren Joseph, Urszula Dougherty, Sujatha Jagadeeswaran, Sonia Cerda, Jeff Nathanson, Nathaniel Little, Anusara Chumsangsri, Reba Mustafi, Greg Cohen
Aberrant crypt foci (ACF) are collections of abnormal colonic crypts with heterogeneous molecular and pathologic characteristics. Large and dysplastic ACF are putative precursors of colon cancer with neoplastic risk related to increased proliferation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ef0490e9ca68594e69d54f677ee16f
https://doi.org/10.1158/0008-5472.c.6494495.v1
https://doi.org/10.1158/0008-5472.c.6494495.v1