Zobrazeno 1 - 10 of 46 pro vyhledávání: '"Shar-yin N. Huang"'
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Akademický článek
Targeting neddylation sensitizes colorectal cancer to topoisomerase I inhibitors by inactivating the DCAF13-CRL4 ubiquitin ligase complex
Autor: Yilun Sun, Simone A. Baechler, Xiaohu Zhang, Suresh Kumar, Valentina M. Factor, Yasuhiro Arakawa, Cindy H. Chau, Kanako Okamoto, Anup Parikh, Bob Walker, Yijun P. Su, Jiji Chen, Tabitha Ting, Shar-yin N. Huang, Erin Beck, Zina Itkin, Crystal McKnight, Changqing Xie, Nitin Roper, Deepak Nijhawan, William Douglas Figg, Paul S. Meltzer, James C. Yang, Craig J. Thomas, Yves Pommier
Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Colorectal cancers (CRCs) are prevalent worldwide, yet current treatments remain inadequate. Using chemical genetic screens, we identify that co-inhibition of topoisomerase I (TOP1) and NEDD8 is synergistically cytotoxic in human CRC cells.
Externí odkaz: https://doaj.org/article/9bbad19d5fd14d8c895c04b8d779aa1f
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2
Akademický článek
PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation
Autor: Yilun Sun, Jiji Chen, Shar-yin N. Huang, Yijun P. Su, Wenjie Wang, Keli Agama, Sourav Saha, Lisa M. Jenkins, John M. Pascal, Yves Pommier
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
TOP1 resolves DNA supercoils by forming cleavage complexes (TOP1cc) that are trapped by TOP1 inhibitors. Here the authors provide insights into the mechanistic understanding of TOP1cc PARylation, showing that inhibition of PARG results in stabilizati
Externí odkaz: https://doaj.org/article/efd9b3f404b3443ca49e78b32652785a
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3
Supplementary Figures 1 - 4 from Stereospecific PARP Trapping by BMN 673 and Comparison with Olaparib and Rucaparib
Autor: Yves Pommier, James H. Doroshow, Beverly Teicher, Joel Morris, Shunichi Takeda, Jiuping Ji, Yiping Zhang, Amèlie Renaud, Shar-Yin N. Huang, Junko Murai
PDF file - 1641K, Supplementary figure 1. Stereospecific targeting of PARP by BMN 673. Supplementary figure 2. Lack of effect of PARP inhibition on ATP concentration. Supplementary figure 3. Flow cytometry analyses after treatment with different PARP
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae9f86c25ef5c53e96039593761b862d
https://doi.org/10.1158/1535-7163.22500088
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5
Data from Biochemical Assays for the Discovery of TDP1 Inhibitors
Autor: Yves Pommier, Anton Simeonov, William L. Jorgensen, Ajit Jadhav, David J. Maloney, Rui Gao, Junko Murai, Ganesha Rai, Andrew S. Rosenthal, Andrew G. Stephen, Alena Naumova, Adel Chergui, Bryan T. Mott, Wendy A. Lea, Thomas S. Dexheimer, Shar-yin N. Huang, Christophe Marchand
Drug screening against novel targets is warranted to generate biochemical probes and new therapeutic drug leads. TDP1 and TDP2 are two DNA repair enzymes that have yet to be successfully targeted. TDP1 repairs topoisomerase I–, alkylation-, and cha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1da67e855c35dcbf7a605e7960b2fa0d
https://doi.org/10.1158/1535-7163.c.6536313
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10
Data from Stereospecific PARP Trapping by BMN 673 and Comparison with Olaparib and Rucaparib
Autor: Yves Pommier, James H. Doroshow, Beverly Teicher, Joel Morris, Shunichi Takeda, Jiuping Ji, Yiping Zhang, Amèlie Renaud, Shar-Yin N. Huang, Junko Murai
Anti-PARP drugs were initially developed as catalytic inhibitors to block the repair of DNA single-strand breaks. We recently reported that several PARP inhibitors have an additional cytotoxic mechanism by trapping PARP–DNA complexes, and that both
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dafa18f1c06df0ed9bd5ee8dd095cf9
https://doi.org/10.1158/1535-7163.c.6536350.v1
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