Zobrazeno 1 - 10
of 340
pro vyhledávání: '"Shaoyong, Lu"'
Delineating the stepwise millisecond allosteric activation mechanism of the class C GPCR dimer mGlu5
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Two-thirds of signaling hormones and one-third of approved drugs exert their effects by binding and modulating the G protein-coupled receptors (GPCRs) activation. While the activation mechanism for monomeric GPCRs has been well-established,
Externí odkaz:
https://doaj.org/article/39581e53858b473cb5cb3cd8bbfd4905
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-43 (2024)
Abstract G protein-coupled receptors (GPCRs), the largest family of human membrane proteins and an important class of drug targets, play a role in maintaining numerous physiological processes. Agonist or antagonist, orthosteric effects or allosteric
Externí odkaz:
https://doaj.org/article/c65fe5256d1847518e22a73b617bb91a
Autor:
Xiaoli Tian, Fu Li, Zhenyuan Tang, Song Wang, Kangkang Weng, Dan Liu, Shaoyong Lu, Wangyu Liu, Zhong Fu, Wenjun Li, Hengwei Qiu, Min Tu, Hao Zhang, Jinghong Li
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Metal-organic frameworks (MOFs) with diverse chemistry, structures, and properties have emerged as appealing materials for miniaturized solid-state devices. The incorporation of MOF films in these devices, such as the integrated microelectro
Externí odkaz:
https://doaj.org/article/02a6a6aed69f43d89f71e4470e55cdc2
Autor:
Xinyuan Xu, Qian Zhang, Xufeng Wang, Jing Jin, Chengwei Wu, Li Feng, Xiuyan Yang, Mingzhu Zhao, Yingyi Chen, Shaoyong Lu, Zhen Zheng, Xiaobing Lan, Yi Wang, Yan Zheng, Xuefeng Lu, Qiufen Zhang, Jian Zhang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 3, Pp 1302-1316 (2024)
Pancreatic cancer, one of the most aggressive malignancies, has no effective treatment due to the lack of targets and drugs related to tumour metastasis. SIRT6 can promote the migration of pancreatic cancer and could be a potential target for antimet
Externí odkaz:
https://doaj.org/article/305cb32e6c0f49d18f0c0ae380b1e656
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Antibiotics are an important pharmaceutical class excessively used by humans. Its presence in the soil can impact plant growth and induce antibiotic resistance. This research studies the effect of sulfamethoxazole (SMX) on plant growth, rhizosphere b
Externí odkaz:
https://doaj.org/article/11364522ec4c4b3a89b01c8abd798846
Autor:
Jie Zhong, Yuegui Guo, Shaoyong Lu, Kun Song, Ying Wang, Li Feng, Zhen Zheng, Qiufen Zhang, Jiacheng Wei, Peng Sang, Yan Shi, Jianfeng Cai, Guoqiang Chen, Chen-Ying Liu, Xiuyan Yang, Jian Zhang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
The adenomatous polyposis coli (APC)–Asef protein interaction is essential for colorectal cancer metastasis. Here, the authors present the rational design of a sensitivity-enhanced tracer for fluorescence polarization assays, enabling them to disco
Externí odkaz:
https://doaj.org/article/a3d21fca29d5450ea4e3c8c472974838
Autor:
Qiufen Zhang, Yingyi Chen, Duan Ni, Zhimin Huang, Jiacheng Wei, Li Feng, Jun-Cheng Su, Yingqing Wei, Shaobo Ning, Xiuyan Yang, Mingzhu Zhao, Yuran Qiu, Kun Song, Zhengtian Yu, Jianrong Xu, Xinyi Li, Houwen Lin, Shaoyong Lu, Jian Zhang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 2, Pp 876-889 (2022)
SIRT6 belongs to the conserved NAD+-dependent deacetylase superfamily and mediates multiple biological and pathological processes. Targeting SIRT6 by allosteric modulators represents a novel direction for therapeutics, which can overcome the selectiv
Externí odkaz:
https://doaj.org/article/fd113152da8f4eababaf6fec04c0e6bb
Autor:
Ying Wang, Mingyu Li, Wenqi Liang, Xinchao Shi, Jigang Fan, Ren Kong, Yaqin Liu, Jian Zhang, Ting Chen, Shaoyong Lu
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 628-639 (2022)
Class B G protein-coupled receptors (GPCRs) are important targets in the treatment of metabolic syndrome and diabetes. Although multiple structures of class B GPCRs–G protein complexes have been elucidated, the detailed activation mechanism of the
Externí odkaz:
https://doaj.org/article/0c11371a0f244c42ad04128dec6bbf8c
Autor:
Haiming Zhuang, Xiaohua Fan, Dong Ji, Yuanhao Wang, Jigang Fan, Mingyu Li, Duan Ni, Shaoyong Lu, Xiaolong Li, Zongtao Chai
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 1352-1365 (2022)
Argonaute (AGO) proteins, the core of RNA-induced silencing complex, are guided by microRNAs (miRNAs) to recognize target RNA for repression. The miRNA–target RNA recognition forms initially through pairing at the seed region while the additional s
Externí odkaz:
https://doaj.org/article/5306dacd299b49bbb2aed289bc3b215e
Autor:
Xiaoliang Cong, Xiaogang Zhang, Xin Liang, Xinheng He, Yehua Tang, Xing Zheng, Shaoyong Lu, Jiayou Zhang, Ting Chen
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 2268-2279 (2022)
As a key regulator for the renin-angiotensin system, a class A G protein-coupled receptor (GPCR), AngII type 2 receptor (AT2R), plays a pivotal role in the homeostasis of the cardiovascular system. Compared with other GPCRs, AT2R has a unique antagon
Externí odkaz:
https://doaj.org/article/58c66cea59fe46f282f3646f492af9c5