Zobrazeno 1 - 10 of 53 pro vyhledávání: '"Shaoxian Sun"'
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Akademický článek
Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers.
Autor: Luping Qiu, Kymberly Levine, Ketan S Gajiwala, Ciarán N Cronin, Asako Nagata, Eric Johnson, Michelle Kraus, John Tatlock, Robert Kania, Timothy Foley, Shaoxian Sun
Publikováno v: PLoS ONE, Vol 13, Iss 6, p e0198374 (2018)
Protein tyrosine kinase 6 (PTK6, or BRK) is aberrantly expressed in breast cancers, and emerging as an oncogene that promotes tumor cell proliferation, migration and evasion. Both kinase-dependent and -independent functions of PTK6 in driving tumor g
Externí odkaz: https://doaj.org/article/14826eba87d1454caa8322f0b783ae9f
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8
Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers
Autor: Robert Steven Kania, Eric Johnson, Tatlock John H, Luping Qiu, Timothy L. Foley, Shaoxian Sun, Kymberly Levine, Ketan S. Gajiwala, Ciarán N. Cronin, Michelle Kraus, Asako Nagata
Publikováno v: PLoS ONE
PLoS ONE, Vol 13, Iss 6, p e0198374 (2018)
Protein tyrosine kinase 6 (PTK6, or BRK) is aberrantly expressed in breast cancers, and emerging as an oncogene that promotes tumor cell proliferation, migration and evasion. Both kinase-dependent and -independent functions of PTK6 in driving tumor g
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ed360b0109ea048c220a42f22b9203e
http://europepmc.org/articles/PMC5991704
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9
Structure-based design, SAR analysis and antitumor activity of PI3K/mTOR dual inhibitors from 4-methylpyridopyrimidinone series
Autor: Shaoxian Sun, Phuong Le, Shubha Bagrodia, Sadayappan V. Rahavendran, Eric Zhang, Cheng Hengmiao, Cathy Xiang, Robert Steven Kania, Jing Yuan, William Farrell, Jacqui Elizabeth Hoffman, Pairish Mason Alan, Deepak Dalvie
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 23:2787-2792
PI3K, AKT and mTOR, key kinases from a frequently dysregulated PI3K signaling pathway, have been extensively pursued to treat a variety of cancers in oncology. Clinical trials of PF-04691502, a highly potent and selective ATP competitive kinase inhib
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::961a901ccd16f3c3b5c282d7080e9b9e
https://doi.org/10.1016/j.bmcl.2013.02.020
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10
Design and synthesis of a novel pyrrolidinyl pyrido pyrimidinone derivative as a potent inhibitor of PI3Kα and mTOR
Autor: Eric Zhang, Shubha Bagrodia, Phuong Le, Hai Wang, Daniel R. Knighton, Cheng Hengmiao, Plewe Michael Bruno, Sacha Ninkovic, Samantha Elizabeth Greasley, Shaoxian Sun, Caroline M. LaFleur Rogers, Andrew Pannifer, Xiaojun Huang, Deepak Dalvie
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 22:5098-5103
Lead optimization efforts that employed structure base drug design and physicochemical property based optimization leading to the discovery of a novel series of 4-methylpyrido pyrimidinone (MPP) are discussed. Synthesis and profile of 1, a PI3Kα/mTO
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa3ea307f0dc069140bb661a2c5f5fdf
https://doi.org/10.1016/j.bmcl.2012.05.100
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