Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Shaoshun Li"'
Autor:
Fan Qiqi, Qingqing Meng, Ting Xu, Jiahua Cui, Chen Dongmei, Zengtao Wang, Jinyun Dong, Shaoshun Li, Jie Wang
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 22:261-269
Background:Cytochrome P450 1B1 (CYP1B1) is specifically expressed in a variety of tumors which makes it a promising imaging target of tumor.Objective:We aimed to design and synthesize CYP1B1 targeted chelators for the potential application in positro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::341941e85ff953eed087c227821397b7
https://doi.org/10.2174/1871520621666210405091645
https://doi.org/10.2174/1871520621666210405091645
Autor:
Zengtao Wang, Dongmei Chen, Qiqi Fan, Zhihao Wu, Jinyun Dong, Jiahua Cui, Jie Wang, Ting Xu, Qingqing Meng, Shaoshun Li
Publikováno v:
ChemBioChem. 23
Cytochrome P450 (CYP) 1B1 has been found to be overexpressed specifically in tumor tissues at an early stage, which makes it a potential cancer biomarker for molecular imaging. Multimodal imaging combines different imaging modalities and offers more
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e43af6183c17d6d399a91e5a7bd01b5e
https://doi.org/10.1002/cbic.202200268
https://doi.org/10.1002/cbic.202200268
Publikováno v:
Current Medicinal Chemistry. 27:5510-5529
Background: Multidrug Resistance (MDR) is defined as a cross-resistance of cancer cells to various chemotherapeutics and has been demonstrated to correlate with drug efflux pumps. Visualization of drug efflux pumps is useful to pre-select patients wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b941d0e29c6452b6f73f7c5778adf383
https://doi.org/10.2174/0929867326666190627123719
https://doi.org/10.2174/0929867326666190627123719
Autor:
Hui-Ran Zhao, Shaoshun Li, Bao-quan Zhu, Jinyun Dong, Guang Huang, Qijing Zhang, Qingqing Meng
Publikováno v:
European Journal of Medicinal Chemistry. 165:160-171
Multi-drug resistance (MDR) to anticancer drugs is the primary impediment to successful treatment of cancer. Hunting for new compounds with potent anti-MDR activity is an effectual approach to conquer cancer drug resistance. In this work, 33 new sulf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fb9292e7de82d52b94c3d4ddc3c3061
https://doi.org/10.1016/j.ejmech.2019.01.005
https://doi.org/10.1016/j.ejmech.2019.01.005
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 18:1714-1732
Thioflavone derivatives are the thio analogs of the core constituent of the natural product class of flavones. Based on the position and oxidation level of sulfur, they can be divided into three major categories: 4-thioflavones, 1-thioflavones and 1-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab12f9c248607d9396ebdf85590e7026
https://doi.org/10.2174/1389557518666180515145633
https://doi.org/10.2174/1389557518666180515145633
Cytotoxicity of Synthesized 1,4-Naphthoquinone Oxime Derivatives on Selected Human Cancer Cell Lines
Publikováno v:
Chemical and Pharmaceutical Bulletin. 66:612-619
In an effort to develop potent and selective antitumor agents, a series of 1,4-naphthoquinone oxime derivatives were designed and synthesized. The cytotoxicity of these compounds were evaluated against five human cancer cell lines (colorectal cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b8ab7a0cf41f63bb097e4647bb33c5
https://doi.org/10.1248/cpb.c18-00013
https://doi.org/10.1248/cpb.c18-00013
Publikováno v:
Russian Journal of General Chemistry. 88:1025-1035
As a continuous study, a set of 23 new 6-substituted 1,4-naphthoquinone oxime derivatives are synthesized and screened for their in vitro cytotoxic activity. Four of those oxime derivatives demonstrate more potent cytotoxic activity towards K562, HCT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9891d8becf97a0c966085ff0c29956f
https://doi.org/10.1134/s1070363218050316
https://doi.org/10.1134/s1070363218050316
Publikováno v:
RSC Advances. 8:15009-15020
The CYP1B1 enzyme is regarded as a potential target for cancer prevention and therapy. Based on the structure of α-naphthoflavone (ANF), diverse 2-arylbenzo[h]quinolone derivatives were designed, synthesized and evaluated as selective CYP1B1 inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32d46ef722c9920827477c33aedbe3c5
https://doi.org/10.1039/c8ra00465j
https://doi.org/10.1039/c8ra00465j
Autor:
Shaoshun Li, Hui-Ran Zhao, Bao-quan Zhu, Qijing Zhang, Jinyun Dong, Guang Huang, Qingqing Meng, Wen Zhou
Publikováno v:
Russian Journal of General Chemistry. 87:2995-2999
Based on thilation by the Lawesson’s reagent (LR), a concise and efficient synthesis of (R or S)-4-methyl-1-(1,4,5,8-tetramethoxynaphthalen-2-yl)pent-3-ene-1-thiol was developed with relatively high yield.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0706bf98e067c69a18991fc3d6a97b7
https://doi.org/10.1134/s1070363217120441
https://doi.org/10.1134/s1070363217120441
Publikováno v:
Russian Journal of General Chemistry. 87:2979-2985
In the present study, a series of 1,4-naphthoquinone oxime derivatives has been synthesized. The structures were confirmed by spectroscopic methods. The newly synthesized compounds were evaluated for their in vitro cytotoxicity. Among those, the comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6d2225477df0908dcb551d284eb1585
https://doi.org/10.1134/s1070363217120416
https://doi.org/10.1134/s1070363217120416