Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Shaoshuai Jiang"'
Autor:
Xiuxiao Tang, Pengguihang Zeng, Kezhi Liu, Li Qing, Yifei Sun, Xinyi Liu, Lizi Lu, Chao Wei, Jia Wang, Shaoshuai Jiang, Jun Sun, Wakam Chang, Haopeng Yu, Hebing Chen, Jiaguo Zhou, Chengfang Xu, Lili Fan, Yi-Liang Miao, Junjun Ding
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract CCCTC-binding factor (CTCF), a ubiquitously expressed and highly conserved protein, is known to play a critical role in chromatin structure. Post-translational modifications (PTMs) diversify the functions of protein to regulate numerous cell
Externí odkaz:
https://doaj.org/article/faa4b4d14dbe448096a8ea86944969cd
Autor:
Jun Sun, Jiale Qu, Cai Zhao, Xinyao Zhang, Xinyu Liu, Jia Wang, Chao Wei, Xinyi Liu, Mulan Wang, Pengguihang Zeng, Xiuxiao Tang, Xiaoru Ling, Li Qing, Shaoshuai Jiang, Jiahao Chen, Tara S. R. Chen, Yalan Kuang, Jinhang Gao, Xiaoxi Zeng, Dongfeng Huang, Yong Yuan, Lili Fan, Haopeng Yu, Junjun Ding
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Understanding intracellular phase separation is crucial for deciphering transcriptional control, cell fate transitions, and disease mechanisms. However, the key residues, which impact phase separation the most for protein phase separation fu
Externí odkaz:
https://doaj.org/article/e247857cd6f6444bb354b68e462cbba0
Publikováno v:
Cell Regeneration, Vol 11, Iss 1, Pp 1-22 (2022)
Abstract Cell fate transition is a fascinating process involving complex dynamics of three-dimensional (3D) chromatin organization and phase separation, which play an essential role in cell fate decision by regulating gene expression. Phase separatio
Externí odkaz:
https://doaj.org/article/445186545c4448f09514c1b9db350b57
Autor:
Mingsen Li, Huaxing Huang, Bofeng Wang, Shaoshuai Jiang, Huizhen Guo, Liqiong Zhu, Siqi Wu, Jiafeng Liu, Li Wang, Xihong Lan, Wang Zhang, Jin Zhu, Fuxi Li, Jieying Tan, Zhen Mao, Chunqiao Liu, Jianping Ji, Junjun Ding, Kang Zhang, Jin Yuan, Yizhi Liu, Hong Ouyang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Genome topology provides a structural basis for epigenome-mediated transcriptional regulation in eukaryotes. Here the authors characterized the 3D genome of stratified squamous epithelia. They generated a Hi-C map of human limbal stem/progenitor cell
Externí odkaz:
https://doaj.org/article/5fa2a3c85bea42989dbd0bb933848395
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-29 (2021)
Abstract Background Biomolecular condensates have been implicated in multiple cellular processes. However, the global role played by condensates in 3D chromatin organization remains unclear. At present, 1,6-hexanediol (1,6-HD) is the only available t
Externí odkaz:
https://doaj.org/article/87cfdac85a1e4dc1977bd0aa9aee2df9
Autor:
Xiaona Huang, Chao Wei, Fenjie Li, Lumeng Jia, Pengguihang Zeng, Jiahe Li, Jin Tan, Tuanfeng Sun, Shaoshuai Jiang, Jia Wang, Xiuxiao Tang, Qingquan Zhao, Bin Liu, Limin Rong, Cheng Li, Junjun Ding
Publikováno v:
Protein & Cell, Vol 10, Iss 10, Pp 709-725 (2019)
ABSTRACT Polycomb group (PcG) ring finger protein 6 (PCGF6), though known as a member of the transcription-repressing complexes, PcG, also has activation function in regulating pluripotency gene expression. However, the mechanism underlying the activ
Externí odkaz:
https://doaj.org/article/f1662bece80242d6a6e8ffd5d9627afa
Autor:
Chao Wei, Lumeng Jia, Xiaona Huang, Jin Tan, Mulan Wang, Jing Niu, Yingping Hou, Jun Sun, Pengguihang Zeng, Jia Wang, Li Qing, Lin Ma, Xinyi Liu, Xiuxiao Tang, Fenjie Li, Shaoshuai Jiang, Jingxin Liu, Tingting Li, Lili Fan, Yujie Sun, Juntao Gao, Cheng Li, Junjun Ding
Publikováno v:
Cell Research. 32:744-760
Chromatin is spatially organized into three-dimensional structures at different levels including A/B compartments, topologically associating domains and loops. The canonical CTCF-mediated loop extrusion model can explain the formation of loops. Howev
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-29 (2021)
Genome Biology
Genome Biology
BackgroundBiomolecular condensates have been implicated in multiple cellular processes. However, the global role played by condensates in 3D chromatin organization remains unclear. At present, 1,6-hexanediol (1,6-HD) is the only available tool to glo
Autor:
Haopeng Yu, Junjun Ding, Shaoshuai Jiang, Cai Zhao, Xiaoxi Zeng, Lumeng Jia, Cheng Li, Wei Zhang, Jianlong Wang, Yangyinhui Yu, Jia Wang, Qian Ma, Xianglin Huang, Yujie Sun, Xinyi Liu, Fenjie Li, Miguel Fidalgo, Jun Sun, Yingping Hou, Jiahao Chen, Yilong Chen, Yi-Liang Miao, Pengguihang Zeng, Danya Wu, Diana Guallar
Publikováno v:
Cell stem cell. 28(10)
Topological-associated domains (TADs) are thought to be relatively stable across cell types, although some TAD reorganization has been observed during cellular differentiation. However, little is known about the mechanisms through which TAD reorganiz
Publikováno v:
REPRODUCTION. 149:485-496
Partially reprogrammed induced pluripotent stem cells (PiPSCs) have great potential for investigating reprogramming mechanisms and represent an alternative potential material for making genetically modified animals and regenerative medicine. To date,