Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Shaoman Zhou"'
Autor:
Longhu Zhou, Hongwang Zhang, Chengwei Li, Coralie De Schutter, Ozkan Sari, Seema Mengshetti, Shaoman Zhou, Mahesh Kasthuri, Steven J. Coats, Raymond F. Schinazi, Franck Amblard
Publikováno v:
ACS Omega, Vol 7, Iss 1, Pp 1452-1461 (2021)
Externí odkaz:
https://doaj.org/article/e014eeef2887439f89555878649fce6a
Autor:
Shaoman Zhou, Franck Amblard, Peng Liu, Zhe Yang, Iulia A. Kovari, Ladislau C. Kovari, Justin Hackett, Nicholas Spellmon, Raymond F. Schinazi, Benjamin D. Kuiper, Joseph S. Brunzelle, Kendall M. Muzzarelli
Publikováno v:
Biochemistry
Norovirus is the leading cause of acute gastroenteritis worldwide with a yearly reported 700 million cases driving a $60 billion global socioeconomic burden. With no United States Food and Drug Administration approved therapeutics and the chance for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41bce1cc9516236e879fe619c50d5e2c
https://doi.org/10.1021/acs.biochem.8b01063
https://doi.org/10.1021/acs.biochem.8b01063
Autor:
Sijia, Tao, Longhu, Zhou, Hongwang, Zhang, Shaoman, Zhou, Sheida, Amiralaei, Jadd, Shelton, Maryam, Ehteshami, Yong, Jiang, Franck, Amblard, Steven J, Coats, Raymond F, Schinazi
Publikováno v:
Nucleosides Nucleotides Nucleic Acids
β-D-2’-C-Methyl-2,6-diaminopurine ribonucleoside (2’-C-Me-DAPN) phosphoramidate prodrug (DAPN-PD) is a selective hepatitis C virus inhibitor that is metabolized intracellularly into two active metabolites: 2’-C-Methyl-DAPN triphosphate (2’-C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3d517a184786af63da1a6f89e46fc4ab
https://pubmed.ncbi.nlm.nih.gov/31595843
https://pubmed.ncbi.nlm.nih.gov/31595843
Autor:
Shaoman Zhou, Raymond F. Schinazi, Ahmed Khalil, Steven J. Coats, Reuben Ovadia, Leda Bassit, Seema Mengshetti, Franck Amblard, Hao Li, Coralie De Schutter
Publikováno v:
Bioorganicmedicinal chemistry. 27(4)
We report herein the synthesis and evaluation of a series of β-d-2'-deoxy-2'-α-chloro-2'-β-fluoro and β-d-2'-deoxy-2'-α-bromo-2'-β-fluoro nucleosides along with their corresponding phosphoramidate prodrugs. Key intermediates, lactols 11 and 12,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1d8696023d0fcf2e4e1be9c3d6a2d14
https://pubmed.ncbi.nlm.nih.gov/30655167
https://pubmed.ncbi.nlm.nih.gov/30655167
Autor:
Jack Yoon, Kendall M. Muzzarelli, Shaoman Zhou, Peng Liu, Benjamin D. Kuiper, Ladislau C. Kovari, Raymond F. Schinazi, Franck Amblard, Bryan Cox
A series of tripeptidyl transition state inhibitors with new P1 and warhead moieties were synthesized and evaluated in a GI-1 norovirus replicon system and against GII-4 and GI-1 norovirus proteases. Compound 19, containing a 6-membered ring at the P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21573d2e96ffb96a94814a3e21368387
https://europepmc.org/articles/PMC6425952/
https://europepmc.org/articles/PMC6425952/
Autor:
Peng Liu, Zhe Yang, Bradley J. Keusch, Ladislau C. Kovari, Shaoman Zhou, Benjamin D. Kuiper, Joshua Holcomb, Iulia A. Kovari, Franck Amblard, Raymond F. Schinazi, Kendall M. Muzzarelli
Publikováno v:
Infect Disord Drug Targets
BACKGROUND: Noroviruses are the leading cause of acute gastroenteritis worldwide. Norovirus proteases, which are responsible for cleavage of the viral polyprotein, have become an attractive drug target to treat norovirus infections. Genogroup II (GII
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d00919e7912490eb04c99fb66b42e9
https://pubmed.ncbi.nlm.nih.gov/29779487
https://pubmed.ncbi.nlm.nih.gov/29779487
Autor:
Shaoman Zhou, Hongwang Zhang, Satish N. Chavre, Lavanya Bondada, Franck Amblard, Sheida Amiralaei, Peng Liu, Jong Hyun Cho, Hao Li, Chengwei Li, Maryam Ehteshami, Raymond F. Schinazi, Judy S. Mathew, Xiao Lu, Sebastien Boucle, Steven J. Coats, Ethel C. Garnier-Amblard, Jadd R. Shelton, Longhu Zhou
Publikováno v:
Antiviral Research. 102:119-147
Chutes and Ladders is an exciting up-and-down-again game in which players race to be the first to the top of the board. Along the way, they will find ladders to help them advance, and chutes that will cause them to move backwards. The development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27c7bbaa1b30731cc2c6ae8a9d62f34
https://doi.org/10.1016/j.antiviral.2013.11.008
https://doi.org/10.1016/j.antiviral.2013.11.008
Publikováno v:
Journal of Medicinal Chemistry. 52:3397-3407
Chiral Z- and E-stereoisomers of (1,2-dihydroxyethyl)methylenecyclopropane analogues of 2'-deoxyadenosine and 2'-deoxyguanosine were synthesized, and their antiviral activity was investigated. (S)-Methylenecyclopropylcarbinol (16) was converted in se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95c857121f90ec54286f5e75b96e48a1
https://doi.org/10.1021/jm900126v
https://doi.org/10.1021/jm900126v
Publikováno v:
Tetrahedron. 63:9406-9412
Synthesis of methylene-2-ethynylcyclopropane analogues of nucleosides 12a , 12b , 13a , and 13b is described. Ethyl methylenecyclopropane carboxylate 14 was hydroxymethylated to give alcohol 15 , which was reduced to diol 16 . Selective protection wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e259d49a2fe53c09704cca3528ba289
https://doi.org/10.1016/j.tet.2007.06.109
https://doi.org/10.1016/j.tet.2007.06.109
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 26:231-243
Synthesis of fluorinated cyclopropavir analogues 13a, 13b, 14a, and 14b is described starting from alkene 15. Addition of carbene derived from dibromofluoromethane gave bromofluoro cyclopropane 16. Reduction (compound 17) followed by desilylation gav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101744a8281d7253b9034c73a8cea2e6
https://doi.org/10.1080/15257770701257210
https://doi.org/10.1080/15257770701257210