Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Shaojun Long"'
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-18 (2024)
Abstract Apicomplexan parasites harbor a complex endomembrane system as well as unique secretory organelles. These complex cellular structures require an elaborate vesicle trafficking system, which includes Rab GTPases and their regulators, to assure
Externí odkaz:
https://doaj.org/article/0af54d2ca539436db316acad401c9023
Autor:
Xi-Ting Wu, Xu-Wen Gao, Qiang-Qiang Wang, Kai He, Muhammad Saqib Bilal, Hui Dong, Yi-Dan Tang, Hui-Yong Ding, Yue-Bao Li, Xiao-Yan Tang, Shaojun Long
Publikováno v:
Parasites & Vectors, Vol 17, Iss 1, Pp 1-20 (2024)
Abstract Background The protozoan parasite Toxoplasma gondii encodes dozens of phosphatases, among which a plant-like phosphatase absent from mammalian genomes named PPKL, which is involved in regulating brassinosteroid signaling in Arabidopsis, was
Externí odkaz:
https://doaj.org/article/ef38cb72c175451a825e2ee8f182f892
Autor:
Hui Dong, Jiong Yang, Kai He, Wen-Bin Zheng, De-Hua Lai, Jing Liu, Hui-Yong Ding, Rui-Bin Wu, Kevin M Brown, Geoff Hide, Zhao-Rong Lun, Xing-Quan Zhu, Shaojun Long
Publikováno v:
eLife, Vol 12 (2024)
The apicoplast is a four-membrane plastid found in the apicomplexans, which harbors biosynthesis and organelle housekeeping activities in the matrix. However, the mechanism driving the flux of metabolites, in and out, remains unknown. Here, we used T
Externí odkaz:
https://doaj.org/article/8397a5d62a4d4a6b99f4c420622439eb
Publikováno v:
Parasites & Vectors, Vol 16, Iss 1, Pp 1-16 (2023)
Abstract Background The protozoan parasite Toxoplasma gondii encodes a dozen Rab proteins, which are parts of the small GTPase superfamily and regulate intracellular membrane trafficking. Our previous study showed that depletion of Rab1B caused sever
Externí odkaz:
https://doaj.org/article/55ac27e4d9f84ba49155511d284e411c
Autor:
Wenyan Wan, Hui Dong, De-Hua Lai, Jiong Yang, Kai He, Xiaoyan Tang, Qun Liu, Geoff Hide, Xing-Quan Zhu, L. David Sibley, Zhao-Rong Lun, Shaojun Long
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Toxoplasma gondii acquires host cytosolic materials, yet the mechanism remains unknown. Wan et al. reveal the micropore as an essential organelle at the plasma membrane for endocytosis of host cytosolic proteins and biotin, and Golgi ceramide.
Externí odkaz:
https://doaj.org/article/c20394fc9378424aad96f749b94f2e74
Autor:
Qiang-Qiang Wang, Ming Sun, Tao Tang, De-Hua Lai, Jing Liu, Sanjay Maity, Kai He, Xi-Ting Wu, Jiong Yang, Yue-Bao Li, Xiao-Yan Tang, Hui-Yong Ding, Geoff Hide, Mark Distefano, Zhao-Rong Lun, Xing-Quan Zhu, Shaojun Long
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT In the apicomplexans, endocytosed cargos (e.g., hemoglobin) are trafficked to a specialized organelle for digestion. This follows a unique endocytotic process at the micropore/cytostome in these parasites. However, the mechanism underlying e
Externí odkaz:
https://doaj.org/article/402a8b5207a94fc08108a12515f8837f
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7172 (2023)
Protein prenylation is an important protein modification that is responsible for diverse physiological activities in eukaryotic cells. This modification is generally catalyzed by three types of prenyl transferases, which include farnesyl transferase
Externí odkaz:
https://doaj.org/article/b791c3d807b74581ac2941d7f52ffd4d
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Apicomplexan parasites such as Toxoplasma gondii possess a tubulin-rich structure called the conoid. Here, Long et al. identify a conoid protein that interacts with motor and structural proteins and is required for structural integrity of the conoid,
Externí odkaz:
https://doaj.org/article/33465d3f02bd4bd9a33944962a813a84
Autor:
Sven-A. Freibert, Alina V. Goldberg, Christian Hacker, Sabine Molik, Paul Dean, Tom A. Williams, Sirintra Nakjang, Shaojun Long, Kacper Sendra, Eckhard Bill, Eva Heinz, Robert P. Hirt, John M Lucocq, T. Martin Embley, Roland Lill
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
The functions of the highly reduced mitochondria (mitosomes) of microsporidians are not well-characterized. Here, the authors show that theTrachipleistophora hominismitosome is the site of iron–sulfur cluster assembly and that its retention is like
Externí odkaz:
https://doaj.org/article/e78ff76691884b4cabe49d811630fe3d
Publikováno v:
Bio-Protocol, Vol 8, Iss 6 (2018)
Defining protein interaction networks can provide key insights into how protein complexes govern complex biological problems. Here we define a method for proximity based labeling using permissive biotin ligase to define protein networks in the intrac
Externí odkaz:
https://doaj.org/article/8f14ee4d54734937a039b3300bb5cfcc