Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Shaojuan Jia"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:6178-6182
As a continuation of our SAR studies of dipeptidyl aspartyl-fmk as caspase inhibitors, we explored the replacement of the P2 amino acid by a 2-aminoaryl acid or other non-natural amino acids. Several of these compounds, such as 6l and 6p, were found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac4778ed66ccfb9a04ccb201648539a3
https://doi.org/10.1016/j.bmcl.2007.09.030
https://doi.org/10.1016/j.bmcl.2007.09.030
Autor:
Daniel P. Walker, Barbara A. Olson, Fusen Han, E. Jon Jacobsen, Raymond S. Hurst, Shaojuan Jia, Lester A. Dolak, Brandon J. Margolis, Nicole R. Higdon, Tatiana N. Vetman, David W. Piotrowski, Brian A. Staton, Matthew R. Hester, Luz A. Cortes-Burgos, Erik H. F. Wong, Theron M. Wall, Steven Charles Reitz, Vincent E. Groppi, Bruce N. Rogers, Kai S. Li, Brad A. Acker, Bruce A. Thornburgh, Paula M. Tinholt, Jason K. Myers, Mihály Hajós, Thomas J. Raub, Mark L. Wolfe, Karen M. Yates, William E. Hoffmann, Laura Fitzgerald, Donn G. Wishka, Eric P. Seest, Rodney R. Walters
Publikováno v:
Bioorganic & Medicinal Chemistry. 14:8219-8248
A novel set of azabicyclic aryl amides have been identified as potent and selective agonists of the alpha7 nAChR. A two-pronged approach was taken to improve the potential hERG liability of previously disclosed alpha7 nAChR agonist, PNU-282,987, whil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::058d11e4149544128cfd448da56d7569
https://doi.org/10.1016/j.bmc.2006.09.019
https://doi.org/10.1016/j.bmc.2006.09.019
Autor:
Lifen Xu, Shailaja Kasibhatla, Nancy Barriault, Denis Labrecque, Jennifer Dodd, Louis Vaillancourt, Shaojuan Jia, Henriette Gourdeau, Serge Lamothe, Ben Tseng, Songchun Jiang, Sui Xiong Cai, Candace Crogan-Grundy, John Drewe, Giorgio Attardo, William Kemnitzer, Real Denis, Sylvie Charron, Hong Zhang, Jianghong Zhao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4745-4751
As a continuation of our efforts to discover and develop the apoptosis inducing 4-aryl-4H-chromenes as novel anticancer agents, we explored the SAR of 4-aryl-4H-chromenes with modifications at the 7- and 5-, 6-, 8-positions. It was found that a small
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9522c973941ac52dd25011ac57c2427
https://doi.org/10.1016/j.bmcl.2005.07.066
https://doi.org/10.1016/j.bmcl.2005.07.066
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:1379-1383
As a continuation of our SAR studies of dipeptidyl aspartyl-fmk as caspase inhibitors, we explored the replacement of the P2 alpha-amino acid by a peptidomimetic alpha-hydroxy acid. These alpha-carbamoyl-alkylcarbonyl-aspartyl fluoromethylketones wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffe296522e3d5435f37c60a9365fa3a8
https://doi.org/10.1016/j.bmcl.2005.01.007
https://doi.org/10.1016/j.bmcl.2005.01.007
Publikováno v:
Polyhedron. 15:2617-2622
The three dimensional polymeric complex [S 4 Cd 17 (SPh) 24 (CH 3 OCS 2 ) 4/2 [ n · n CH 3 OH ( 1 ) has been synthesized from the reaction of [Cd 4 (SPh) 6 (SPh) 4/2 [ n with CS 2 , DMF and MeOH, and structurally characterized by X-ray diffraction a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e43b972ef22b00f5e0570a8e0dd8588
https://doi.org/10.1016/0277-5387(95)00544-7
https://doi.org/10.1016/0277-5387(95)00544-7
Publikováno v:
ChemInform. 36
This article describes the synthesis and biological evaluation of a group of N-protected Val-Asp-fmk as caspase inhibitors. The protecting group was found to contribute to caspase-3 inhibiting activity, and compounds with a large group such as Cbz ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1402738e3587ed49ea9c694ff7680886
https://doi.org/10.1002/chin.200509189
https://doi.org/10.1002/chin.200509189
Autor:
Richard Storer, Ben Tseng, Denis Labreque, John Drewe, Giorgio Attardo, Shailaja Kasibhatla, Jianghong Zhao, Henriette Gourdeau, Yan Wang, Songchun Jiang, David Y. Bouffard, Rabindra Rej, Real Denis, Hong Zhang, William Kemnitzer, Serge Lamothe, Sui Xiong Cai, Karen Meerovitch, John Herich, Charles Blais, Shaojuan Jia
Publikováno v:
Journal of medicinal chemistry. 47(25)
By applying a novel cell- and caspase-based HTS assay, 2-amino-3-cyano-7-(dimethylamino)-4-(3-methoxy-4,5-methylenedioxyphenyl)-4H-chromene (1a) has been identified as a potent apoptosis inducer. Compound 1a was found to induce nuclear fragmentation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28b55f712fbfe080e63799b21a712bb8
https://pubmed.ncbi.nlm.nih.gov/15566300
https://pubmed.ncbi.nlm.nih.gov/15566300
Autor:
John Herich, Bao Nguyen, Sui Xiong Cai, Shailaja Kasibhatla, Ben Tseng, John Drewe, John Guastella, Shaojuan Jia, Sanjeeva Reddy
Publikováno v:
Journal of medicinal chemistry. 46(12)
By applying a novel cell- and caspase-based HTS assay, a series of N-phenyl nicotinamides has been identified as a new class of potent inducers of apoptosis. Through SAR studies, a 20-fold increase in potency was achieved from a screening hit N-(4-me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29ebab6a68bcb699df92924682d89343
https://pubmed.ncbi.nlm.nih.gov/12773051
https://pubmed.ncbi.nlm.nih.gov/12773051
Akademický článek
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Autor:
Shaojuan Jia, Bottomley, Jennifer M.
Publikováno v:
GeriNotes; Nov2013, Vol. 20 Issue 6, p20-24, 5p