Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Shaojian Gao"'
Autor:
Nitin Roper, Anna-Leigh Brown, Jun S. Wei, Svetlana Pack, Christopher Trindade, Chul Kim, Olivia Restifo, Shaojian Gao, Sivasish Sindiri, Farid Mehrabadi, Rajaa El Meskini, Zoe Weaver Ohler, Tapan K. Maity, Abhilash Venugopalan, Constance M. Cultraro, Elizabeth Akoth, Emerson Padiernos, Haobin Chen, Aparna Kesarwala, DeeDee K. Smart, Naris Nilubol, Arun Rajan, Zofia Piotrowska, Liqiang Xi, Mark Raffeld, Anna R. Panchenko, Cenk Sahinalp, Stephen Hewitt, Chuong D. Hoang, Javed Khan, Udayan Guha
Publikováno v:
Cell Reports Medicine, Vol 1, Iss 1, Pp 100007- (2020)
Summary: Clonal evolution of osimertinib-resistance mechanisms in EGFR mutant lung adenocarcinoma is poorly understood. Using multi-region whole-exome and RNA sequencing of prospectively collected pre- and post-osimertinib-resistant tumors, including
Externí odkaz:
https://doaj.org/article/bd88b4540b1e47469281d9cfc6d07cbc
Autor:
Yue A. Qi, Tapan K. Maity, Shaojian Gao, Tao Gong, Meriam Bahta, Abhilash Venugopalan, Xu Zhang, Udayan Guha
Publikováno v:
Cancers, Vol 13, Iss 19, p 4977 (2021)
Immune checkpoint inhibitor (ICI) therapy has been a paradigm shift in the treatment of cancer. ICI therapy results in durable responses and survival benefit for a large number of tumor types. Osimertinib, a third-generation epidermal growth factor r
Externí odkaz:
https://doaj.org/article/030967cc7f5b48068685cd6b3aee550f
Autor:
Nitin Roper, Shaojian Gao, Tapan K. Maity, A. Rouf Banday, Xu Zhang, Abhilash Venugopalan, Constance M. Cultraro, Rajesh Patidar, Sivasish Sindiri, Anna-Leigh Brown, Alexander Goncearenco, Anna R. Panchenko, Romi Biswas, Anish Thomas, Arun Rajan, Corey A. Carter, David E. Kleiner, Stephen M. Hewitt, Javed Khan, Ludmila Prokunina-Olsson, Udayan Guha
Publikováno v:
Cell Reports, Vol 26, Iss 10, Pp 2651-2666.e6 (2019)
Summary: Intratumor mutational heterogeneity has been documented in primary non-small-cell lung cancer. Here, we elucidate mechanisms of tumor evolution and heterogeneity in metastatic thoracic tumors (lung adenocarcinoma and thymic carcinoma) using
Externí odkaz:
https://doaj.org/article/a89fb160e8244d76991306067b2f929e
Autor:
Dennis Liang Fei, Hayley Motowski, Rakesh Chatrikhi, Sameer Prasad, Jovian Yu, Shaojian Gao, Clara L Kielkopf, Robert K Bradley, Harold Varmus
Publikováno v:
PLoS Genetics, Vol 12, Iss 10, p e1006384 (2016)
We have asked how the common S34F mutation in the splicing factor U2AF1 regulates alternative splicing in lung cancer, and why wild-type U2AF1 is retained in cancers with this mutation. A human lung epithelial cell line was genetically modified so th
Externí odkaz:
https://doaj.org/article/920131dbdd724f3ab20d3c18f0c03afd
Autor:
Shaojian Gao, Donald L. Nuss
Publikováno v:
Molecular Plant-Microbe Interactions, Vol 11, Iss 11, Pp 1130-1135 (1998)
Targeted disruption of cpg-1, a gene encoding the G protein Giα subunit, CPG-1, in the chestnut blight fungus, Cryphonectria parasitica, results in reduced mycelial growth, reduced orange pigmentation, loss of virulence, loss of asexual sporulation,
Externí odkaz:
https://doaj.org/article/a2678804658847e2b0cd5af54c779e5f
Autor:
R. Taylor Ripley, David S. Schrump, Jonathan M. Hernandez, Chuong D. Hoang, Jeremy L. Davis, Leonard M. Neckers, Derek J. Nancarrow, David G. Beer, Laurence P. Diggs, Kaitlin C. McLoughlin, Sichuan Xi, Shaojian Gao, Min-Jung Lee, Sunmin Lee, Jane B. Trepel, Daniel R. Crooks, Emily S. Reardon, Vivek Shukla, Lucas A. McDuffie, Yuan Xu, Kate Brown, Deborah R. Surman, Paul L. Feingold
RNAse Esc2 TXNIP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59cb2352cf6ee8517ba836977219d285
https://doi.org/10.1158/1535-7163.22505272.v1
https://doi.org/10.1158/1535-7163.22505272.v1
Autor:
R. Taylor Ripley, David S. Schrump, Jonathan M. Hernandez, Chuong D. Hoang, Jeremy L. Davis, Leonard M. Neckers, Derek J. Nancarrow, David G. Beer, Laurence P. Diggs, Kaitlin C. McLoughlin, Sichuan Xi, Shaojian Gao, Min-Jung Lee, Sunmin Lee, Jane B. Trepel, Daniel R. Crooks, Emily S. Reardon, Vivek Shukla, Lucas A. McDuffie, Yuan Xu, Kate Brown, Deborah R. Surman, Paul L. Feingold
In 2017, an estimated 17,000 individuals were diagnosed with esophageal adenocarcinoma (EAC), and less than 20% will survive 5 years. Positron emission tomography avidity is indicative of high glucose utilization and is nearly universal in EAC. TXNIP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e340b99ca40389ffa9f98c0fced22dc
https://doi.org/10.1158/1535-7163.c.6538015.v1
https://doi.org/10.1158/1535-7163.c.6538015.v1
Autor:
R. Taylor Ripley, David S. Schrump, Jonathan M. Hernandez, Chuong D. Hoang, Jeremy L. Davis, Leonard M. Neckers, Derek J. Nancarrow, David G. Beer, Laurence P. Diggs, Kaitlin C. McLoughlin, Sichuan Xi, Shaojian Gao, Min-Jung Lee, Sunmin Lee, Jane B. Trepel, Daniel R. Crooks, Emily S. Reardon, Vivek Shukla, Lucas A. McDuffie, Yuan Xu, Kate Brown, Deborah R. Surman, Paul L. Feingold
Cells and Reagents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bce5e7960c6cb1e98e4c8f87eeb3406
https://doi.org/10.1158/1535-7163.22505263
https://doi.org/10.1158/1535-7163.22505263
Autor:
R. Taylor Ripley, David S. Schrump, Jonathan M. Hernandez, Chuong D. Hoang, Jeremy L. Davis, Leonard M. Neckers, Derek J. Nancarrow, David G. Beer, Laurence P. Diggs, Kaitlin C. McLoughlin, Sichuan Xi, Shaojian Gao, Min-Jung Lee, Sunmin Lee, Jane B. Trepel, Daniel R. Crooks, Emily S. Reardon, Vivek Shukla, Lucas A. McDuffie, Yuan Xu, Kate Brown, Deborah R. Surman, Paul L. Feingold
Supplemental Figure 1: Chromatin immunoprecipitation was performed to assess the histone modification marks, H3K27Me3, H3K9Ac2, H3K4Me3, and H3K79Me2 in Flo-1 and Esc2 after glutamine withdrawal; Supplemental Figure 2: qRT-PCR normalized to b-actin m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ddae6a9e59936bf7cb288418158c173
https://doi.org/10.1158/1535-7163.22505275
https://doi.org/10.1158/1535-7163.22505275
Autor:
Udayan Guha, Cathy Wu, Fatos Kirkali, Julie Cowart, Khoa Dang P. Nguyen, Shaojian Gao, Meghana Keswani, Stephanie Pitts, Meriam Bahta, Constance M. Cultraro, Yue Qi, Karen E. Ross, Tapan K. Maity, Xu Zhang
Supplementary Fig.S5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6562ea9b987c59e355990fc5562c554
https://doi.org/10.1158/0008-5472.22429771.v1
https://doi.org/10.1158/0008-5472.22429771.v1