Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Shaogao Zeng"'
Autor:
Shaogao Zeng, Songlin Fang, Haiping Cai, Dong Wang, Weiliang Liu, Xinwei Hu, Pinghua Sun, Zhixiong Ruan
Publikováno v:
Chemistry – An Asian Journal. 17
A novel selenium-electrocatalytic intramolecular cyclization of 2-vinylanilides for synthesis of functionalized indoles and azaindoles has been developed. In contrast to the previous synthetic methods, this sustainable protocol enabled unparalleled b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e113802c69cc35f243b0d232d432e1
https://doi.org/10.1002/asia.202200762
https://doi.org/10.1002/asia.202200762
Publikováno v:
Science China Chemistry. 64:800-807
The installation of azoles via C–H/N–H cross-coupling is significantly underdeveloped, particularly in benzylic C–H azolation due to the requirement for external chemical oxidants and the challenge in controlling the site- and chemo-selectivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9546d76516c7e3ee92654081a4a32573
https://doi.org/10.1007/s11426-020-9938-9
https://doi.org/10.1007/s11426-020-9938-9
Autor:
Guo Jiehuang, Nan Zhao, Xin Zhao, Shaogao Zeng, Yang Zhou, Wenhui Hu, Qiaoli Zhou, Yanfang Ma, Wenyuan Dou, Manna Li, Hui Xie, Hong Huang
Publikováno v:
ChemMedChem. 15:1608-1617
Long-acting dipeptidyl peptidase IV inhibitors have emerged as promising molecules for interventions for type 2 diabetes. Once weekly dosing brings greater patient compliance and more stable glycemic control. Starting from our previous highly potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::187745cd3d298cb3a64982d11d353d11
https://doi.org/10.1002/cmdc.202000175
https://doi.org/10.1002/cmdc.202000175
Autor:
Zhongnan Xu, Zhixiong Ruan, Yucheng Zheng, Yueheng Li, Ping-Hua Sun, Guangquan Mo, Shaogao Zeng
Publikováno v:
Organic Letters. 22:4016-4020
The electrochemical phosphorylation of aldehyde hydrazones has been developed under exogenous oxidant-free conditions. The strategy provides expedient access to highly functionalized α-iminophosphine oxides with ample scope and broad functional grou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::686788d35e67213a7e2291605e305725
https://doi.org/10.1021/acs.orglett.0c01343
https://doi.org/10.1021/acs.orglett.0c01343
Autor:
Xuefei Ji, Guifa Zhong, Lu-Yi Li, Donghai Wu, Xiurong Rao, Kejian Zhang, Dengfeng Xu, Libo Zou, Wenhui Hu, Wei Zhou, Hao Wang, Micky D. Tortorella, Guoqing Sheng, Xing Ji, Sihai Fu, Xiaorong Liu, Shaogao Zeng, Hui Xie, Tianyan Chi
Publikováno v:
ACS Chemical Neuroscience. 7:1499-1507
Currently, anti-AD drug discovery using target-based approaches is extremely challenging due to unclear etiology of AD and absence of validated therapeutic protein targets. Neuronal death, regardless of causes, plays a key role in AD progression, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe6bec729a1bbc6f1efc26765e84f06d
https://doi.org/10.1021/acschemneuro.6b00125
https://doi.org/10.1021/acschemneuro.6b00125
Autor:
Chris Ka Pun Mok, Ping Sun, Shaogao Zeng, Runfeng Li, Wei Cui, Chunguang Yang, Chunlong Ma, Yang Zhou, Wenhui Hu, Yaoquan Tu, Jianghong Dong, Jun Wang, Yanmei Hu, Zhongjin Yang, Qiuling Du, Mengjie Xiao, Kefeng Wang, Haiming Jiang, Zifeng Yang, Xin Zhao
Influenza pandemic is a constant major threat to public health caused by influenza A viruses (IAV). IAVs are sub-categorized by the surface proteins: hemagglutinin (HA) and neuraminidase (NA), in which they are both essential targets for drug discove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8488cd2861af723fae399a2b3746623e
https://europepmc.org/articles/PMC6496959/
https://europepmc.org/articles/PMC6496959/
Autor:
Guifa Zhong, Hongjiang Xu, Hui Xie, Xin Zhao, Yuwen He, Shaogao Zeng, Guicheng Zhang, Wenhui Hu, Pengjiu Yu, Ling Yang, Wang Shanchun
Publikováno v:
European journal of medicinal chemistry. 141
Drug compliance is critical for patients with chronic diseases such as diabetes. In our continuous effort to find better glucose-lowering agents, an exploration for long-acting DPP-4 inhibitors had been launched. Based on our previously reported comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e3cf45989d01a9ee8a57d877dd0b08e
https://pubmed.ncbi.nlm.nih.gov/29078995
https://pubmed.ncbi.nlm.nih.gov/29078995
Autor:
Shaogao Zeng, Wenhui Hu, Guicheng Zhang, Ling Yang, Hui Xie, Xin Zhao, Wang Shanchun, Zhengchao Tu, Xiquan Zhang, Hongjiang Xu, Lili Zeng, Xin Lu
Publikováno v:
European Journal of Medicinal Chemistry. 68:312-320
The superposition of the DPP-IV complex revealed that the butynyl group of Linagliptin can be freely switched with the cyanobenzyl group of Alogliptin. Thus, a pharmacophore hybridization of Alogliptin was initiated and led to a novel DPP-IV inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b25ded23930c887023da3df927c736d3
https://doi.org/10.1016/j.ejmech.2013.08.010
https://doi.org/10.1016/j.ejmech.2013.08.010
Autor:
Matthew R. Rosenberg, Marco G. Casarotto, Junting Wan, Zhiyuan Li, Wei Cui, Zhengchao Tu, Wenhui Hu, Yanling Jie, Yiping Xiao, Shaogao Zeng, Xin Zhao
Publikováno v:
Antiviral Research. 96:91-99
The adamantanes are a class of anti-influenza drugs that inhibit the M2 ion channel of the influenza A virus. However recently, the clinical effectiveness of these drugs has been called into question due to the emergence of adamantane-insensitive A/M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb47af8fc94d290c8dc32e760c83b7f5
https://doi.org/10.1016/j.antiviral.2012.09.001
https://doi.org/10.1016/j.antiviral.2012.09.001
Autor:
Wenhui Hu, Xiurong Rao, Wei Zhou, Tianyan Chi, Libo Zou, Guifa Zhong, Hui Xie, Shaogao Zeng, Donghai Wu
Publikováno v:
ACS Medicinal Chemistry Letters. 3:903-907
Targeting neuroinflammation may be a new strategy to combat Alzheimer's disease. An aminopyridazine 1b previously reported as a novel antineuroinflammatory agent was considered to have a potential therapeutic effect for Alzheimer's disease. In this s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e045a909a197bf4e2a29722f25880d
https://doi.org/10.1021/ml3001769
https://doi.org/10.1021/ml3001769