Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Shao-Lin Zhang"'
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103182- (2024)
Summary: S-acylation of proteins allows their association with membranes. Here, we present a protocol for establishing a platform for membrane affinity evaluation of S-acylated proteins in vitro. We describe steps for preparing lipid-maleimide compou
Externí odkaz:
https://doaj.org/article/1b83aab1a76049d198ce83569b399657
Publikováno v:
Molecules, Vol 29, Iss 13, p 3029 (2024)
The regulation of the cancer cell cycle heavily relies on cyclin-dependent kinases (CDKs). Targeting CDKs has been identified as a promising approach for effective cancer therapy. In recent years, there has been significant attention paid towards dev
Externí odkaz:
https://doaj.org/article/3521bf3b9c3e49d3877eac7f55abb7e1
Publikováno v:
Acta Crystallographica Section E, Vol 68, Iss 6, Pp o1752-o1752 (2012)
In the title molecule, C22H20N4O4S, both C=N bonds are in an E conformation. The benzene rings form dihedral angles of 12.10 (13) and 25.17 (12)° with the thiophene ring. The dihedral angle between the two benzene rings is 17.59 (14)°. There are tw
Externí odkaz:
https://doaj.org/article/9c6d4170ec094039a51fcbd58a0b557a
Publikováno v:
Journal of Medicinal Chemistry. 66:4910-4931
Publikováno v:
Journal of Agricultural and Food Chemistry. 71:2322-2332
Autor:
Xiaohong Yang, Zhi-Peng Wang, Sichuan Xiang, Daoqiang Wang, Yi Zhao, Dong Luo, Yanfei Qiu, Chao Huang, Jian Guo, Yuanwei Dai, Shao-Lin Zhang, Yun He
Publikováno v:
Journal of Medicinal Chemistry. 65:8040-8061
Calothrixin A (
Publikováno v:
International Journal of Automation and Computing. 18:926-934
In the existing modular joint design and control methods of collaborative robots, the inertia of the manipulator link is large, the dynamic trajectory planning ability is weak, the collision stop safety strategy is dependent, and the adaptability and
Autor:
Ding, Huang, Maojie, Zhang, Haiyan, Zhang, Zhiying, Cui, Dong, Luo, Tao, Li, Xuemin, Li, Yun, He, Shao-Lin, Zhang
Publikováno v:
Bioorganicmedicinal chemistry letters. 77
Mitomycin C (MMC) is a class of alkylating anticancer drug, which non-specifically interacts with nuclear DNA and cross-links guanine and cytosine of DNA, thereby affecting DNA replication and synthesis. However, toxic effects largely impeded MMC's c
Autor:
Ding Huang, Qingwang Liu, Maojie Zhang, Yizhen Guo, Zhiying Cui, Tao Li, Dong Luo, Biao Xu, Chao Huang, Jian Guo, Kin Yip Tam, Min Zhang, Shao-Lin Zhang, Yun He
Publikováno v:
Journal of medicinal chemistry. 65(14)
Phenylbutyric acid (PBA) has been reported as a dual inhibitor of pyruvate dehydrogenase kinases (PDKs) and histone deacetylases (HDACs), exhibiting anticancer effects. However, the low membrane permeability and poor cellular uptake limit its access
Publikováno v:
Drug Discovery Today. 26:836-844
Cancer cells metabolize glucose via anaerobic glycolysis, with lactate formed in the cytosol as the end-product. To avoid intercellular acidification, excessive lactate and proton are excreted by monocarboxylate transporters (MCTs), which are often o