Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Shao Sha"'
Publikováno v:
In Petroleum Science October 2024 21(5):3222-3236
Genomic evidence for rediploidization and adaptive evolution following the whole-genome triplication
Autor:
Xiao Feng, Qipian Chen, Weihong Wu, Jiexin Wang, Guohong Li, Shaohua Xu, Shao Shao, Min Liu, Cairong Zhong, Chung-I Wu, Suhua Shi, Ziwen He
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Whole-genome duplication (WGD), or polyploidy, events are widespread and significant in the evolutionary history of angiosperms. However, empirical evidence for rediploidization, the major process where polyploids give rise to diploid descen
Externí odkaz:
https://doaj.org/article/7da1b5147d3744c4aa986fd17cbe1bff
Autor:
Xun Wu, Shao Sha, Yong Yin, Yang Zhou, Hai-Liang Zhu, Zhong-Cheng Song, Fang Qiao, She-Feng Wang
Publikováno v:
Bioorganic chemistry. 92
PI3K pathway has been heavily studied and is one of the most potential targets for various cancer treatment. Herein, we designed and synthesized a series of novel chromeno[4,3-c]pyrazol-4(2H)-one derivates contained piperazine based on our previous r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a3bbf4265b935344b206cf7d377a3b6
https://pubmed.ncbi.nlm.nih.gov/31499259
https://pubmed.ncbi.nlm.nih.gov/31499259
Publikováno v:
European journal of medicinal chemistry. 182
PI3K signal pathway plays a vital role in cellular functions and becomes an attractive approach for cancer therapy. Herein, a new series of novel chromeno[4,3-c]pyrazol-4(2H)-one derivatives bearing sulfonylpiperazine based on the PI3K inhibitors and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e668791c997c24655c42174b352953
https://pubmed.ncbi.nlm.nih.gov/31446244
https://pubmed.ncbi.nlm.nih.gov/31446244
Autor:
Fang Qiao, She-Feng Wang, Hai-Liang Zhu, Shao Sha, Xu Wu, Jia-Qin Hu, Zhong-Cheng Song, Yong Yin
Publikováno v:
Bioorganicmedicinal chemistry. 27(11)
A series of novel chromeno[4,3-c]pyrazol-4(2H)-one derivates contained sulfonamido were designed and synthesized, and their anticancer effects in vitro was evaluated to develop some new PI3Kα inhibitors. Most of desired compounds exhibited the bette
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9133e44e3e7108e06973473c7c655cb7
https://pubmed.ncbi.nlm.nih.gov/31029551
https://pubmed.ncbi.nlm.nih.gov/31029551
Autor:
Hai-Liang Zhu, Baozhong Wang, Yan-Dong Liu, Shao Sha, Guo-Dong Ju, Liang Lu, Kai Wang, Yuan-Heng Zhang
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 64:1576-1581
A series of novel chromeno[4,3-c]pyrazol-4(2H)-one containing carbonyl or oxime derivatives (4a-n, 5a-n) have been synthesized and evaluated their biological activities as phosphatidyl inositol 3-kinase (PI3K) inhibitors. Out of them, compound 5l sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::231eeb1b3035e1a7c1dc0fba24f515a8
https://doi.org/10.1248/cpb.c16-00388
https://doi.org/10.1248/cpb.c16-00388
Autor:
Yan-Ting Wang, Hai-Liang Zhu, Peng-Cheng Lv, Fang Qiao, Xun Wu, She-Feng Wang, Yong Yin, Shao Sha
Publikováno v:
Chemical Biology & Drug Design. 86:1323-1329
VEGFR2 has been proved to play a major role in the regulation of tumor angiogenesis. Twenty-one 4-alkoxyquinazoline-based derivatives have been designed and synthesized as vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors, and their b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad698b3f296f60113abdb18c7276518f
https://doi.org/10.1111/cbdd.12596
https://doi.org/10.1111/cbdd.12596
Autor:
Shao Sha, Wei-Qing Zhong, Fei Gao, Zhen Li, Hong-Wei Han, Tian-Bao Liu, Hai-Liang Zhu, Chi Xu
Publikováno v:
MedChemComm. 6:2029-2035
Phosphoinositide 3-kinase (PI3K) is an attractive target to potentially treat a range of disease states as illustrated by more than 15 inhibitors now in clinical trials. We disclose herein the discovery of a new class of fluoroquinolone derivatives h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b662d0bc559231c6a91e504207faa1a
https://doi.org/10.1039/c5md00364d
https://doi.org/10.1039/c5md00364d
Autor:
Shao Sha, Zhu Hailiang, Wei-Ming Zhang, Yong Yin, Yu-Ning Shen, Chen Xu, Aimin Lu, Fang Qiao, She-Feng Wang, Xun Wu
Publikováno v:
RSC Advances. 5:19914-19923
A series of 4-alkoxyquinazoline derivatives containing the 1,3,4-oxadiazole scaffold have been designed and synthesized, and their inhibitory activities were also tested against A549, MCF-7 and Hela. Of these compounds, 2-(3,4-dimethoxybenzyl)-5-((qu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4db1353dda9ea36d100e17428dd40b6f
https://doi.org/10.1039/c4ra11780h
https://doi.org/10.1039/c4ra11780h
Autor:
She-Feng, Wang, Yong, Yin, Xun, Wu, Fang, Qiao, Shao, Sha, Peng-Cheng, Lv, Jing, Zhao, Hai-Liang, Zhu
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:5727-5737
A series of 4-hydroxycoumarin derivatives were designed and synthesized in order to find some more potent antibacterial drugs. Their antibacterial activities against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e8885b141392586c7b76f818227b4d9
https://doi.org/10.1016/j.bmc.2014.09.048
https://doi.org/10.1016/j.bmc.2014.09.048