Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Shao, Pengcheng Patrick"'
Autor:
Shao, Pengcheng Patrick
A series of chelating amino siloxide and alkoxide ligands have been prepared. Barium, lanthanide and zirconium complexes bearing these new ligands have been synthesized and characterized by NMR or X-ray crystallography. Reactivity of the zirconium co
Externí odkaz:
https://dspace.library.uvic.ca//handle/1828/9776
Autor:
Robert O. Blaustein, Georgy Hartmann, Guiquan Liu, Dennis Leung, Beth Ann Murphy, Sriram Tyagarajan, Yingju Xu, Zhijian Lu, Jian Liu, Louis-Charles Campeau, Sheng-Ping Wang, Daniel Metzger, Joseph L. Duffy, Qinghao Chen, Josee Cote, Rupesh P. Amin, Debra Ondeyka, Jianming Bao, Wanying Sun, Yi-Heng Chen, Peter J. Sinclair, Concetta Lipardi, Feng Ye, Douglas G. Johns, Katipally Revathi Reddy, Petr Vachal, Kaushik Mitra, Gordon K. Wollenberg, Shao Pengcheng Patrick, Kake Zhao, Lushi Tan
Publikováno v:
Journal of Medicinal Chemistry. 64:13215-13258
Cholesteryl ester transfer protein (CETP) represents one of the key regulators of the homeostasis of lipid particles, including high-density lipoprotein (HDL) and low-density lipoprotein (LDL) particles. Epidemiological evidence correlates increased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::573c5ff3dfab385ab49a4f550abe8129
https://doi.org/10.1021/acs.jmedchem.1c00959
https://doi.org/10.1021/acs.jmedchem.1c00959
Autor:
Daniel Metzger, Joseph L. Duffy, Weiguo Liu, Jiafang He, Garry Chicchi, Gino Salituro, Ann E. Weber, Margaret Wu, Cai Li, John Wang, Taro E. Akiyama, Andrew D. Howard, Shao Pengcheng Patrick, John Bawiec, Beth Ann Murphy, Gui-Bai Liang, Yun-Ping Zhou, Susan D. Aster, Kwei-Lan Tsao, Jin Shang
Publikováno v:
ACS Medicinal Chemistry Letters. 9:1082-1087
[Image: see text] We report new SSTR5 antagonists with enhanced potency, subtype selectivity, and minimal off-target activities as compared to previously reported compounds. Starting from the reported SSTR5 antagonist 1, we systematically surveyed ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f799c113adab203716f4e156f34e4f72
https://doi.org/10.1021/acsmedchemlett.8b00305
https://doi.org/10.1021/acsmedchemlett.8b00305
Autor:
Maria Rico del Rosario Ferreira, Lorna Helen Mitchell, Yue Fang, Michael J. Neeb, Robert K. Boeckman, Shao Pengcheng Patrick
Publikováno v:
Tetrahedron. 67:9787-9808
A full account of studies that culminated in the total synthesis of both antipodes and the assignment of its absolute configuration of Saudin, a hypoglycemic natural product. Two approaches are described, the first proceeding though bicyclic lactone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b81c69df3f77873b626456feb322a1e3
https://doi.org/10.1016/j.tet.2011.09.067
https://doi.org/10.1016/j.tet.2011.09.067
Autor:
Ying-Duo Gao, Maria L. Garcia, Xiaohua Li, Catherine Abbadie, Daniel R. McMasters, Feng Ye, Brande S. Williams, William J. Martin, Kathryn A. Lyons, Ann E. Weber, Gregory J. Kaczorowski, John P. Felix, McHardy M. Smith, Shao Pengcheng Patrick, William H. Parsons, Birgit T. Priest, Erin McGowan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5334-5338
A series of novel isoxazole voltage gated sodium channel blockers have been synthesized and evaluated. Substitutions on the benzylic position of benzamide were investigated to determine their effect on Na(v)1.7 inhibitory potency. The spirocyclobutyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701dc8af84f883465fcabf2285c21877
https://doi.org/10.1016/j.bmcl.2009.07.135
https://doi.org/10.1016/j.bmcl.2009.07.135
Autor:
Feng Ye, Shao Pengcheng Patrick
Publikováno v:
Tetrahedron Letters. 49:3554-3557
A stereoselective approach to the synthesis of cis - and trans -3-fluoro-1-phenylcyclobutylamine has been developed. Excellent stereoselectivity was obtained by the reduction of the appropriately substituted cyclobutanone to give either cis- or trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb0e0a510b826cfe5b4782d98a1a6b7f
https://doi.org/10.1016/j.tetlet.2008.04.018
https://doi.org/10.1016/j.tetlet.2008.04.018
Autor:
Rainer Vollmerhaus, Shao Pengcheng Patrick, Stewart P. Lewis, Robert Tomaszewski, Kevin John Wiacek, Scott Collins, Nicholas J. Taylor, ‡ and Abdulaziz Al-Humydi
Publikováno v:
Organometallics. 24:494-507
The syntheses of a variety of iminophosphonamide (PN2) ligands (2a−f), the corresponding hydrochloride salts (1a−c), and a number of bis(PN2) dichloride complexes of group 4 (3a−e) and their corres...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18e12cf7d07151a8c44fd7161fa66efd
https://doi.org/10.1021/om0492350
https://doi.org/10.1021/om0492350
Autor:
Charles J. Cohen, Margaret Z Chou, Brande S. Williams, Yui S. Tang, Ivy E. Dick, Brita S. Reiseter, Maria L. Garcia, Gregory J. Kaczorowski, Keith A. Wafford, William J. Martin, Samantha Clark, Vivien A. Warren, Peter T. Meinke, Ge Dai, William H. Parsons, Richard E. Middleton, William A. Schmalhofer, Martin Köhler, McHardy M. Smith, Richard M. Brochu, Shao Pengcheng Patrick, Chou J. Liu, Birgit T. Priest, John P. Felix
Publikováno v:
Biochemistry. 43:9866-9876
Sodium channel blockers are used clinically to treat a number of neuropathic pain conditions, but more potent and selective agents should improve on the therapeutic index of currently used drugs. In a high-throughput functional assay, a novel sodium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d3ddd47eae5772bd4e88e362138fc4d
https://doi.org/10.1021/bi0493259
https://doi.org/10.1021/bi0493259
Publikováno v:
Canadian Journal of Chemistry. 78:255-264
A series of aminodiols RN(CH2CH2C(OH)Rprime2)2 (R, Rprime = Me, Me 4; Me, Ph 5; tert-butyl, Me 6; tert-Bu, Ph 7; (S)-PhCH(Me), Me 8) were prepared by the Michael addition of a primary amine to methyl acrylate followed by reaction of the resulting ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87edd092c127401bf78d4eff0af14849
https://doi.org/10.1139/v00-001
https://doi.org/10.1139/v00-001