Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Shanya Jiang"'
Autor:
Kathryn E. Sánchez, Shanya Jiang, Sharina Palencia Desai, Jeffery Thompson, Sasha Hobson, Gary A. Rosenberg, Kiran Bhaskar
Publikováno v:
STAR Protocols, Vol 5, Iss 1, Pp 102916- (2024)
Summary: Apoptosis-associated speck-like protein containing a c-terminal caspase activation and recruitment domain (ASC) specks are elevated in the cerebrospinal fluid (CSF) of Alzheimer’s disease and related dementias (AD/ADRDs) patients. Here, we
Externí odkaz:
https://doaj.org/article/cdb71a31e5af421cb405829c89c0a119
Autor:
Jessica Binder, Oleg Ursu, Cristian Bologa, Shanya Jiang, Nicole Maphis, Somayeh Dadras, Devon Chisholm, Jason Weick, Orrin Myers, Praveen Kumar, Jeremy J. Yang, Kiran Bhaskar, Tudor I. Oprea
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Jessica Binder et al. developed a machine learning model to discover potential drug targets for Alzheimer’s disease. They validated their 20 top candidates in several in vitro models, and highlight FRRS1, CTRAM, SCGB3A1, FAM92B/CIBAR2, and TMEFF2 a
Externí odkaz:
https://doaj.org/article/eafe528a0fb444148715ee8fe57ec23e
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-13 (2021)
Abstract Background The presence of hyperphosphorylated microtubule-associated protein tau is strongly correlated with cognitive decline and neuroinflammation in Alzheimer’s disease and related tauopathies. However, the role of inflammation and ant
Externí odkaz:
https://doaj.org/article/d005f055f84b4408b526e30866bcdaaf
Autor:
Florencia A. Monge, Adeline M. Fanni, Patrick L. Donabedian, Jonathan Hulse, Nicole M. Maphis, Shanya Jiang, Tia N. Donaldson, Benjamin J. Clark, David G. Whitten, Kiran Bhaskar, Eva Y. Chi
Publikováno v:
Biosensors, Vol 13, Iss 2, p 151 (2023)
The identification of protein aggregates as biomarkers for neurodegeneration is an area of interest for disease diagnosis and treatment development. In this work, we present novel super luminescent conjugated polyelectrolyte molecules as ex vivo sens
Externí odkaz:
https://doaj.org/article/eea97f2b5cc84265bf1a2ce7ac74a9fc
Autor:
Shanya Jiang, Nicole M. Maphis, Jessica Binder, Devon Chisholm, Lea Weston, Walter Duran, Crina Peterson, Amber Zimmerman, Michael A. Mandell, Stephen D. Jett, Eileen Bigio, Changiz Geula, Nikolaos Mellios, Jason P. Weick, Gary A. Rosenberg, Eicke Latz, Michael T. Heneka, Kiran Bhaskar
Publikováno v:
Cell Reports, Vol 36, Iss 12, Pp 109720- (2021)
Summary: Pathological hyperphosphorylation and aggregation of tau (pTau) and neuroinflammation, driven by interleukin-1β (IL-1β), are the major hallmarks of tauopathies. Here, we show that pTau primes and activates IL-1β. First, RNA-sequence analy
Externí odkaz:
https://doaj.org/article/d7ff525d710c4c41847bd98e6f7f0a7b
Autor:
Shanya Jiang, Kiran Bhaskar
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Tauopathies are a class of neurodegenerative diseases, including Alzheimer’s disease (AD), Frontotemporal Dementia (FTD), Progressive Supranuclear Palsy (PSP), Corticobasal Degeneration (CBD), and many others where microtubule-associated protein ta
Externí odkaz:
https://doaj.org/article/472a5d9e11c14d1d944950f9e51cb010
Autor:
Kiran Bhaskar, Shanya Jiang, Somayeh Dadras, Jonathan P Hulse, Karthikeyan Tangavelou, Devon C Chisholm, Michael Mandell
Publikováno v:
Alzheimer's & Dementia. 18
Autor:
Soiba Khalid Mansoor, Laurel O. Sillerud, Judy L. Cannon, David S. Peabody, Fadi A. Jamaleddin Ahmad, Jonathan L. Brigman, Erin Crossey, Kiran Bhaskar, Yirong Yang, Amanda Yaney, Julianne Peabody, Bryce Chackerian, Colin M. Wilson, Maria Alvarez, Nicole Maphis, Shanya Jiang, Reed Selwyn
Publikováno v:
npj Vaccines, Vol 4, Iss 1, Pp 1-13 (2019)
NPJ Vaccines
NPJ Vaccines
Tauopathies, including frontotemporal dementia (FTD) and Alzheimer’s disease (AD) are progressive neurodegenerative diseases clinically characterized by cognitive decline and could be caused by the aggregation of hyperphosphorylated pathological ta
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-13 (2021)
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-13 (2021)
Background The presence of hyperphosphorylated microtubule-associated protein tau is strongly correlated with cognitive decline and neuroinflammation in Alzheimer’s disease and related tauopathies. However, the role of inflammation and anti-inflamm
Autor:
Kiran Bhaskar, Shanya Jiang
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience
Tauopathies are a class of neurodegenerative diseases, including Alzheimer’s disease (AD), Frontotemporal Dementia (FTD), Progressive Supranuclear Palsy (PSP), Corticobasal Degeneration (CBD), and many others where microtubule-associated protein ta