Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Shany Guly Gofrit"'
Autor:
Valery Golderman, Shany Guly Gofrit, Yanina Ivashko-Pachima, Illana Gozes, Joab Chapman, Efrat Shavit-Stein
Publikováno v:
Heliyon, Vol 10, Iss 12, Pp e33329- (2024)
The cell surface protease-activated receptor 1 (PAR1) is overexpressed in glioblastoma multiforme (GBM). We studied the function and structure of intracellular microtubule (MT) and PAR1 in a tubulin-mediated process. We found that exposure to thrombi
Externí odkaz:
https://doaj.org/article/c7d00b6de06646ca9df866eb20e72615
Autor:
Valery Golderman, Marina Ben-Shimon, Nicola Maggio, Amir Dori, Shany Guly Gofrit, Shani Berkowitz, Lamis Qassim, Avital Artan-Furman, Talya Zeimer, Joab Chapman, Efrat Shavit-Stein
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-16 (2022)
Abstract Background Inflammation and coagulation are linked and pathogenic in neuroinflammatory diseases. Protease-activated receptor 1 (PAR1) can be activated both by thrombin, inducing increased inflammation, and activated protein C (aPC), inducing
Externí odkaz:
https://doaj.org/article/4c1a170703a24d97a16202238f8b022f
Autor:
Shany Guly Gofrit, Yoav Yechezkel Pikkel, Hagai Levine, Shifra Fraifeld, Shlomzion Kahana Merhavi, Limor Friedensohn, Ruth Eliahou, Tamir Ben-Hur, Asaf Honig
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
BackgroundMeningitis and meningoencephalitis (MME) are potential medical emergencies. Mandatory reporting of all MME cases in the Israel Defense Force (IDF) allows accurate characterization of MME incidence and course. In the present study, we descri
Externí odkaz:
https://doaj.org/article/c600f5c8faad42fdb97244132b686b0d
Autor:
Alexandra Gerasimov, Valery Golderman, Shany Guly Gofrit, Shay Anat Aharoni, Daniela Noa Zohar, Ze’ev Itsekson-Hayosh, Tsviya Fay-Karmon, Sharon Hassin-Baer, Joab Chapman, Nicola Maggio, Efrat Shavit-Stein
Publikováno v:
Neural Regeneration Research, Vol 16, Iss 10, Pp 2086-2092 (2021)
Inflammation and coagulation are tightly interconnected in the pathophysiology of neuronal diseases. Thrombin, a pro-coagulant serine protease is associated with neurodegeneration and its indirect inhibitor, activated protein C (aPC), is considered n
Externí odkaz:
https://doaj.org/article/f8010ee07e7645e4ba682a2c255e20a0
Autor:
Valery Golderman, Zehavit Goldberg, Shany Guly Gofrit, Amir Dori, Nicola Maggio, Joab Chapman, Ifat Sher, Ygal Rotenstreich, Efrat Shavit-Stein
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2021 (2023)
Diabetic encephalopathy (DE) is an inflammation-associated diabetes mellitus (DM) complication. Inflammation and coagulation are linked and are both potentially modulated by inhibiting the thrombin cellular protease-activated receptor 1 (PAR1). Our a
Externí odkaz:
https://doaj.org/article/8ceb1322924842e0a54e9f48e3ae45d4
Autor:
Shani Berkowitz, Shany Guly Gofrit, Shay Anat Aharoni, Valery Golderman, Lamis Qassim, Zehavit Goldberg, Amir Dori, Nicola Maggio, Joab Chapman, Efrat Shavit-Stein
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10472 (2022)
Background. Due to the interactions between neuroinflammation and coagulation, the neural effects of lipopolysaccharide (LPS)-induced inflammation (1 mg/kg, intraperitoneal (IP), n = 20) and treatment with the anti-thrombotic enoxaparin (1 mg/kg, IP,
Externí odkaz:
https://doaj.org/article/d083dc606b7c4cd6b8b779866275f6f0
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0248431 (2021)
BackgroundIschemic stroke is a common and debilitating disease with limited treatment options. Protease activated receptor 1 (PAR1) is a fundamental cell signaling mediator in the central nervous system (CNS). It can be activated by many proteases in
Externí odkaz:
https://doaj.org/article/33b59608a4db4c398458f6e04b81a04e
Publikováno v:
Neural Plasticity, Vol 2021 (2021)
The cholinergic system plays a fundamental role in learning and memory. Pharmacological activation of the muscarinic receptor M1R potentiates NMDA receptor activity and induces short-term potentiation at the synapses called muscarinic LTP, mLTP. Dysf
Externí odkaz:
https://doaj.org/article/de7b22c9b8fb4ef7a728bf02f08adcdf
Autor:
Shani Berkowitz, Joab Chapman, Amir Dori, Shany Guly Gofrit, Nicola Maggio, Efrat Shavit-Stein
Publikováno v:
Biomedicines, Vol 9, Iss 12, p 1950 (2021)
Complement and coagulation are both key systems that defend the body from harm. They share multiple features and are similarly activated. They each play individual roles in the systemic circulation in physiology and pathophysiology, with significant
Externí odkaz:
https://doaj.org/article/d20b75cf3dab444d8eb69a1e4d0583b0
Autor:
Efrat Shavit-Stein, Ramona Aronovich, Constantin Sylantiev, Shany Guly Gofrit, Joab Chapman, Amir Dori
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0219453 (2019)
Diabetic neuropathy is common and disabling despite glycemic control. Novel neuroprotective approaches are needed. Thrombin and hypercoagulability are associated with diabetes and nerve conduction dysfunction. Our aim was to study the role of thrombi
Externí odkaz:
https://doaj.org/article/9ce70936db294acf80919875da1ef7e7