Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Shanti S Srivastava"'
Autor:
Xing Zhu, Dhiraj Mannar, Shanti S Srivastava, Alison M Berezuk, Jean-Philippe Demers, James W Saville, Karoline Leopold, Wei Li, Dimiter S Dimitrov, Katharine S Tuttle, Steven Zhou, Sagar Chittori, Sriram Subramaniam
Publikováno v:
PLoS Biology, Vol 19, Iss 4, p e3001237 (2021)
The recently reported "UK variant" (B.1.1.7) of SARS-CoV-2 is thought to be more infectious than previously circulating strains as a result of several changes, including the N501Y mutation. We present a 2.9-Å resolution cryo-electron microscopy (cry
Externí odkaz:
https://doaj.org/article/3c1f36e42d5749cfa2e5fb28488e1f6f
Autor:
Dhiraj Mannar, James W. Saville, Xing Zhu, Shanti S. Srivastava, Alison M. Berezuk, Katharine S. Tuttle, Ana Citlali Marquez, Inna Sekirov, Sriram Subramaniam
Publikováno v:
Science. 375:760-764
The newly reported Omicron variant is poised to replace Delta as the most prevalent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant across the world. Cryo–electron microscopy (cryo-EM) structural analysis of the Omicron variant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09faa4a1613c55d84f2d3b0b462f0f5d
https://doi.org/10.1126/science.abn7760
https://doi.org/10.1126/science.abn7760
Publikováno v:
Chemical reviews. 122(17)
The global spread of SARS-CoV-2 has proceeded at an unprecedented rate. Remarkably, characterization of the virus using modern tools in structural biology has also progressed at exceptional speed. Advances in electron-based imaging techniques, combin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b7c885021c1f9c763b4aeda657e9d74
https://pubmed.ncbi.nlm.nih.gov/35863749
https://pubmed.ncbi.nlm.nih.gov/35863749
Autor:
Dhiraj Mannar, James W. Saville, Xing Zhu, Shanti S. Srivastava, Alison M. Berezuk, Katharine S. Tuttle, Citlali Marquez, Inna Sekirov, Sriram Subramaniam
The newly reported Omicron variant is poised to replace Delta as the most rapidly spread SARS-CoV-2 variant across the world. Cryo-EM structural analysis of the Omicron variant spike protein in complex with human ACE2 reveals new salt bridges and hyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cdf3eafcbbbed6176389b78c0058f4f
https://doi.org/10.1101/2021.12.19.473380
https://doi.org/10.1101/2021.12.19.473380
Autor:
Dhiraj Mannar, James W. Saville, Zehua Sun, Xing Zhu, Michelle M. Marti, Shanti S. Srivastava, Alison M. Berezuk, Steven Zhou, Katharine S. Tuttle, Michele D. Sobolewski, Andrew Kim, Benjamin R. Treat, Priscila Mayrelle Da Silva Castanha, Jana L. Jacobs, Simon M. Barratt-Boyes, John W. Mellors, Dimiter S. Dimitrov, Wei Li, Sriram Subramaniam
Mutations in the spike glycoproteins of SARS-CoV-2 variants of concern have independently been shown to enhance aspects of spike protein fitness. Here, we report the discovery of a novel antibody fragment (VH ab6) that neutralizes all major variants,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::599b36466a717133151dfb669d3c98dc
https://doi.org/10.1101/2021.12.17.473178
https://doi.org/10.1101/2021.12.17.473178
Autor:
Dhiraj Mannar, James W. Saville, Zehua Sun, Xing Zhu, Michelle M. Marti, Shanti S. Srivastava, Alison M. Berezuk, Steven Zhou, Katharine S. Tuttle, Michele D. Sobolewski, Andrew Kim, Benjamin R. Treat, Priscila Mayrelle Da Silva Castanha, Jana L. Jacobs, Simon M. Barratt-Boyes, John W. Mellors, Dimiter S. Dimitrov, Wei Li, Sriram Subramaniam
Publikováno v:
Nature communications. 13(1)
Mutations in the spike glycoproteins of SARS-CoV-2 variants of concern have independently been shown to enhance aspects of spike protein fitness. Here, we describe an antibody fragment (VH ab6) that neutralizes all major variants including the recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c2fc05fd9886f016b8b157b91a114e5
https://pubmed.ncbi.nlm.nih.gov/35982054
https://pubmed.ncbi.nlm.nih.gov/35982054
Autor:
Dhiraj Mannar, James W. Saville, Zehua Sun, Xing Zhu, Michelle M. Marti, Shanti S. Srivastava, Alison M. Berezuk, Steven Zhou, Katharine S. Tuttle, Michele D. Sobolewski, Andrew Kim, Benjamin R. Treat, Priscila Mayrelle Da Silva Castanha, Jana L. Jacobs, Simon M. Barratt-Boyes, John W. Mellors, Dimiter S. Dimitrov, Wei Li, Sriram Subramaniam
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
SARS-CoV-2 variants have accumulated multiple defining mutations within their spike glycoproteins. Here, the authors report a structural basis for broad neutralization of several variants by a heavy chain antibody fragment and provide a mutational an
Externí odkaz:
https://doaj.org/article/8507bc9f2a6c4b9e85210fb73299d3d4
Autor:
James W. Saville, Dhiraj Mannar, Xing Zhu, Shanti S. Srivastava, Alison M. Berezuk, Jean-Philippe Demers, Steven Zhou, Katharine S. Tuttle, Inna Sekirov, Andrew Kim, Wei Li, Dimiter S. Dimitrov, Sriram Subramaniam
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Saville, Mannar et al. provide a structural basis for enhanced antibody evasion and ACE2 binding by the Delta SARS-CoV-2 spike protein. They further identify a head-to-head dimer-of-trimers cryoEM reconstruction unique to the Kappa variant spike.
Externí odkaz:
https://doaj.org/article/feef3d51eb6145eeb9cb3f29799a3060