Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Shanthi Wasser"'
Autor:
Yan Cheng, Allen G. Rodrigo, Peizhen Hu, Stéphane Guindon, Theresa M.C. Tan, Seng Gee Lim, Lay Yong Lee, Bee Leng Seet, F. Peter, Matthew Goode, Shanthi Wasser
Publikováno v:
Gastroenterology. 133:951-958
Background & Aims: Although viral quasi-species evolution may be related to pathogenesis of disease, little is known about this in hepatitis B virus (HBV); consequently, we aimed to evaluate the evolution of HBV quasi-species in patients with well-ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91c789683f5dc97b4e745ec6f9232aed
https://doi.org/10.1053/j.gastro.2007.06.011
https://doi.org/10.1053/j.gastro.2007.06.011
Autor:
Yan Cheng, Carmen Shair Ling Ong, Seng Gee Lim, Shanthi Wasser, Theresa M.C. Tan, Bee Leng Seet, F. Peter
Publikováno v:
Antiviral Research. 69:142-151
In vitro studies of HBV core promoter mutations in hepatoma cell lines suggest that some mutations in core promoter transcription factor binding sites result in reduced core promoter activity and viral replication. We sought to validate this hypothes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce496c9a06ce5d3e19aa756862a16ee
https://doi.org/10.1016/j.antiviral.2005.11.005
https://doi.org/10.1016/j.antiviral.2005.11.005
Publikováno v:
Journal of Gastroenterology and Hepatology. 16:1244-1253
Background: Hepatic fibrosis occurs because of injury to the liver parenchyma and biliary system. We have investigated the effect of an organic selenium anti-oxidant, ebselen, in the resolution of experimentally induced hepatic fibrosis, and evaluate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49b1c32fba88e53f89ac2c63b59e54c0
https://doi.org/10.1046/j.1440-1746.2001.02621.x
https://doi.org/10.1046/j.1440-1746.2001.02621.x
Publikováno v:
Life Sciences. 69:309-326
Extract of Salvia Miltiorrhiza (SM) has been widely used in traditional Chinese medicine for treating liver diseases. Recent experimental evidence indicates that it has anti-tumor potential. In this study, the effect of SM on alfatoxin B1 (AFB1)-indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84556893f7e5113bf2aab85754d970cd
https://doi.org/10.1016/s0024-3205(01)01116-x
https://doi.org/10.1016/s0024-3205(01)01116-x
AIM: To investigate the role of polo-like kinase 1 (PLK1) as a therapeutic target for hepatocellular carcinoma (HCC). METHODS: PLK1 gene expression was evaluated in HCC tissue and HCC cell lines. Gene knockdown with short-interfering RNA (siRNA) was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::025f541f66837d77771824b1fc350810
https://europepmc.org/articles/PMC3400854/
https://europepmc.org/articles/PMC3400854/
Autor:
Seng Gee Lim, Myat Oo Aung, Yang Li, Shanthi Wasser, Theresa M.C. Tan, Weiqi Tan, Thomas W.L. Neo
Publikováno v:
Cancer science. 100(7)
MicroRNAs are tiny RNA molecules which serve as important post-transcriptional regulators of gene expression. Dysregulated expression of microRNAs has been observed in human cancers, indicating that microRNAs may function as oncogenes or as tumor sup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ad6301214403f4d6469c3701bcf5b67
https://pubmed.ncbi.nlm.nih.gov/19486339
https://pubmed.ncbi.nlm.nih.gov/19486339
Publikováno v:
Virus research. 136(1-2)
Chronic hepatitis B infection is a major cause of morbidity and mortality worldwide. Despite effective vaccine and treatments, often unavailable in highly prevalent areas in Asia and Africa, the disease and economic burdens of the condition remain ve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::417cada40a7a2d684d902a5a20bfa00a
https://pubmed.ncbi.nlm.nih.gov/18579251
https://pubmed.ncbi.nlm.nih.gov/18579251
Autor:
Daniel M. Davis, Clare Selden, Esther N. M. Nolte-`t Hoen, Antonio Bertoletti, Mala K. Maini, Adam J. Gehring, Shanthi Wasser, Patrick T F Kennedy, Seng Gee Lim, Dianxing Sun, Michael Nassal
CD8 T cells exert their antiviral function through cytokines and lysis of infected cells. Because hepatocytes are susceptible to noncytolytic mechanisms of viral clearance, CD8 T-cell antiviral efficiency against hepatotropic viruses has been linked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fbf0c28e8988d5795e16ae2b2d7d1b3
https://europepmc.org/articles/PMC1866017/
https://europepmc.org/articles/PMC1866017/
Publikováno v:
Cellular and molecular life sciences : CMLS. 61(16)
Small interfering RNA (siRNA) has been used repeatedly to down-regulate viral gene expression and inhibit viral replication in mammalian cells. In this study, we showed that siRNAs specific for two conserved regions within the hepatitis B S antigen (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::544e0f9a66607e34b92dcda94b5b4e6f
https://pubmed.ncbi.nlm.nih.gov/15316660
https://pubmed.ncbi.nlm.nih.gov/15316660
Publikováno v:
Carcinogenesis. 21(12)
Aflatoxin B(1) (AFB(1)), a potent hepatocarcinogen, enhances ROS formation and causes oxidative DNA damage, which may play a role in its carcinogenicity. We have demonstrated recently that ebselen, an organic selenium compound, protects against the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c7f3bf27ae2c5be396ff07400725f15
https://pubmed.ncbi.nlm.nih.gov/11133813
https://pubmed.ncbi.nlm.nih.gov/11133813