Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Shanthi R. Paranawithana"'
Autor:
Ramadevi Nimmanapalli, Shanthi R. Paranawithana, Carlos Fumero, Sylvie Wittman, Hong Gang Wang, Purva Bali, Kapil N. Bhalla, Erica O'Bryan, David Griffin, Fei Guo
Publikováno v:
Blood. 99:3419-3426
Second mitochondria-derived activator of caspases (Smac)/DIABLO is a mitochondrial protein that is released into the cytosol along with cytochrome c (cyt c) during the execution of the intrinsic pathway of apoptosis. Smac/DIABLO promotes apoptosis by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa70a5d3b18956536919404d63da2d44
https://doi.org/10.1182/blood.v99.9.3419
https://doi.org/10.1182/blood.v99.9.3419
Autor:
Yizheng Tan, Christopher J. Patten, Mong Heng Wang, Shanthi R. Paranawithana, Chung S. Yang, Guang-Yu Yang
Publikováno v:
Archives of Biochemistry and Biophysics. 334:380-388
In order to study the interaction between human cytochrome P450 2E1 (h2E1) and NADPH–P450 oxidoreductase (hOR) in a native membrane environment, we used two approaches to express both h2E1 and hOR in a baculovirus expression system. For a dual-expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aceb8d437a61215e986f282aae40163
https://doi.org/10.1006/abbi.1996.0468
https://doi.org/10.1006/abbi.1996.0468
Publikováno v:
Archives of Biochemistry and Biophysics. 302:337-342
Previous work in our laboratory demonstrated that cytochrome P450 2B1 in rat liver was induced, but P450 2E1 was inhibited and inactivated, by diallyl sulfide (DAS), a compound derived from garlic. Such a selective effect on P450 enzymes is of consid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::157b6d9ab1021d9757810254d3fee698
https://doi.org/10.1006/abbi.1993.1220
https://doi.org/10.1006/abbi.1993.1220
Enhancement of the catalytic properties of human carbonic anhydrase III by site-directed mutagenesis
Autor:
David N. Silverman, Shanthi R. Paranawithana, Philip J. Laipis, Susan M. Tanhauser, Chingkuang Tu, David Jewell, Philip LoGrasso
Publikováno v:
Biochemistry. 30:1484-1490
Among the seven known isozymes of carbonic anhydrase in higher vertebrates, isozyme III is the least efficient in catalytic hydration of CO2 and the least susceptible to inhibition by sulfonamides. We have investigated the role of two basic residues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88eadf7d38264af6883c31fed6632baf
https://doi.org/10.1021/bi00220a006
https://doi.org/10.1021/bi00220a006
Autor:
Michael R. Green, Katherine E. Frato, Haihong Shen, Clara L. Kielkopf, E. Allen Sickmier, Shanthi R. Paranawithana
Publikováno v:
Molecular cell. 23(1)
The essential pre-mRNA splicing factor, U2AF(65), guides the early stages of splice site choice by recognizing a polypyrimidine (Py) tract consensus sequence near the 3' splice site. Since Py tracts are relatively poorly conserved in higher eukaryote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca901bce31e2e954cb90e01ccdf5ef0
https://pubmed.ncbi.nlm.nih.gov/16818232
https://pubmed.ncbi.nlm.nih.gov/16818232
Autor:
E. Allen Sickmier, Dimitris Brekasis, Mark S. B. Paget, Shanthi R. Paranawithana, Clara L. Kielkopf, Jeffrey B. Bonanno, Stephen K. Burley
Publikováno v:
Structure (London, England : 1993). 13(1)
The redox-sensing repressor Rex regulates transcription of respiratory genes in response to the intra cellular NADH/NAD(+) redox poise. As a step toward elucidating the molecular mechanism of NADH/NAD(+) sensing, the X-ray structure of Thermus aquati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68dae082ad3dd754d47547a8bb3291f5
https://pubmed.ncbi.nlm.nih.gov/15642255
https://pubmed.ncbi.nlm.nih.gov/15642255
Autor:
Hirohito, Yamaguchi, Shanthi R, Paranawithana, Michael W, Lee, Ziwei, Huang, Kapil N, Bhalla, Hong-Gang, Wang
Publikováno v:
Cancer research. 62(2)
Epothilone B is a novel nontaxane antimicrotubule agent that is active even against paclitaxel (Taxol)-resistant cancer cells. The present study further explores the mechanisms underlying epothilone B-mediated cytotoxicity in human breast cancer cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7b4fc756aabf62263cdb3cbcfb0aa4a3
https://pubmed.ncbi.nlm.nih.gov/11809697
https://pubmed.ncbi.nlm.nih.gov/11809697
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 27(3)
1. A model for the active site structure of human cytochrome P4502E1 based on the coordinates of cytochrome P450BM-3 crystal structure and the sequence analysis information on P4502E1 was proposed. 2. The sequence alignment of mammalian P4502 family
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c9f742d3dae445ea517c1e39ed16cc7
https://pubmed.ncbi.nlm.nih.gov/9141236
https://pubmed.ncbi.nlm.nih.gov/9141236
Autor:
Chingkuang Tu, David N. Silverman, George C. Wynns, Shanthi R. Paranawithana, Philip LoGrasso, Susan M. Tanhauser, David Jewell, Philip J. Laipis
Publikováno v:
Biochemistry. 29(27)
Among the isozymes of carbonic anhydrase, isozyme III is the least efficient in the catalysis of the hydration of CO2 and was previously thought to be unaffected by proton transfer from buffers to the active site. We report that buffers of small size
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df4708fd5e3ea9f510921617157b4af
https://pubmed.ncbi.nlm.nih.gov/2169869
https://pubmed.ncbi.nlm.nih.gov/2169869
Publikováno v:
Biochemistry. 25:2205-2211
A conformational change in the DNA plasmid ColE_1 appears to occur upon specific binding of the restriction endonuclease EcoRI. Enzyme association alters the chiral discrimination found in binding metallointercalators to DNA sites. The complexes tris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99e2c8fd29196869dd1652f5978ba63f
https://doi.org/10.1021/bi00356a053
https://doi.org/10.1021/bi00356a053