Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Shantha K. Mahadevaiah"'
Autor:
Charlotte Douglas, Valdone Maciulyte, Jasmin Zohren, Daniel M. Snell, Shantha K. Mahadevaiah, Obah A. Ojarikre, Peter J. I. Ellis, James M. A. Turner
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
In areas such as animal research and agriculture a single sex is often required in abundance, leading to wasted resources and ethical considerations. Here the authors develop a CRISPR/Cas9 mediated synthetic lethal system that enables the production
Externí odkaz:
https://doaj.org/article/212d0ada3e1b4efc91787d0acfd6cf85
Autor:
Sissy E. Wamaitha, Katarzyna J. Grybel, Gregorio Alanis-Lobato, Claudia Gerri, Sugako Ogushi, Afshan McCarthy, Shantha K. Mahadevaiah, Lyn Healy, Rebecca A. Lea, Miriam Molina-Arcas, Liani G. Devito, Kay Elder, Phil Snell, Leila Christie, Julian Downward, James M. A. Turner, Kathy K. Niakan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The signals regulating the establishment and maintenance of the pluripotent epiblast in human embryos are unclear. Here, the authors use a bioinformatics approach to identify the role of IGF1 in human embryo development, and from this, propose a cult
Externí odkaz:
https://doaj.org/article/104a33cb9a9247e1b51c23eb671ab8a2
Autor:
Alexander Widger, Shantha K. Mahadevaiah, Julian Lange, Elias ElInati, Jasmin Zohren, Takayuki Hirota, Sarai Pacheco, Andros Maldonado-Linares, Marcello Stanzione, Obah Ojarikre, Valdone Maciulyte, Dirk G. de Rooij, Attila Tóth, Ignasi Roig, Scott Keeney, James M.A. Turner
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
ATR kinase is required for meiosis in non-mammalian model organisms. Here the authors demonstrate, using a tissue-specific knockout approach, that ATR is also essential for male meiosis in mouse, regulating meiotic recombination and synapsis.
Externí odkaz:
https://doaj.org/article/b92089ad88aa43c8bc4181f628f431ba
Autor:
Aminata Touré, Emily J. Clemente, Peter J. I. Ellis, Shantha K. Mahadevaiah, Obah A. Ojarikre, Penny A. F. Ball, Louise Reynard, Kate L. Loveland, Paul S. Burgoyne, Nabeel A. Affara
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-1 (2019)
Following publication of the original article [1], the following error was reported: The actin control panel in Fig. 3 of this paper is reproduced from Fig. 7 of Touré et al, 2004 [2] by kind permission of the Genetics Society of America. Touré et
Externí odkaz:
https://doaj.org/article/2efd19ffbef44fa18f17703ba7741e86
Autor:
Catalina Pereira, Gerardo A Arroyo-Martinez, Matthew Z Guo, Michael S Downey, Emma R Kelly, Kathryn J Grive, Shantha K Mahadevaiah, Jennie R Sims, Vitor M Faca, Charlton Tsai, Carl J Schiltz, Niek Wit, Heinz Jacobs, Nathan L Clark, Raimundo Freire, James Turner, Amy M Lyndaker, Miguel A Brieno-Enriquez, Paula E Cohen, Marcus B Smolka, Robert S Weiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96989669e5391ebd7aac62be78017e04
https://doi.org/10.7554/elife.68677.sa2
https://doi.org/10.7554/elife.68677.sa2
Autor:
Catalina Pereira, Gerardo A Arroyo-Martinez, Matthew Z Guo, Michael S Downey, Emma R Kelly, Kathryn J Grive, Shantha K Mahadevaiah, Jennie R Sims, Vitor M Faca, Charlton Tsai, Carl J Schiltz, Niek Wit, Heinz Jacobs, Nathan L Clark, Raimundo Freire, James Turner, Amy M Lyndaker, Miguel A Brieno-Enriquez, Paula E Cohen, Marcus B Smolka, Robert S Weiss
Publikováno v:
eLife, Vol 11 (2022)
DNA damage response mechanisms have meiotic roles that ensure successful gamete formation. While completion of meiotic double-strand break (DSB) repair requires the canonical RAD9A-RAD1-HUS1 (9A-1-1) complex, mammalian meiocytes also express RAD9A an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::777add2079b5e1a2379c789d8f281a1c
Autor:
Heinz Jacobs, Miguel A. Brieño-Enríquez, Arroyo-Martinez Ga, Amy M. Lyndaker, Turner Jma, Kathryn J. Grive, Vitor M. Faça, Marcus B. Smolka, Guo Mz, Robert S. Weiss, Shantha K. Mahadevaiah, Carl J. Schiltz, Niek Wit, Charlton Tsai, Downey Ms, Kelly Er, Paula E. Cohen, Raimundo Freire, Catalina Pereira, Nathan L. Clark, Jennie Rae Sims
DNA damage response mechanisms have meiotic roles that ensure successful gamete formation. While completion of meiotic double-strand break (DSB) repair requires the canonical RAD9A-RAD1-HUS1 (9A-1-1) complex, mammalian meiocytes also express RAD9A an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::348039b0b06f0c35aece47a78ddadb7b
https://doi.org/10.1101/2021.04.09.439198
https://doi.org/10.1101/2021.04.09.439198
Autor:
James M. A. Turner, Obah A. Ojarikre, Shantha K. Mahadevaiah, Charlotte Douglas, Daniel M Snell, Valdone Maciulyte, Peter J. I. Ellis, Jasmin Zohren
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Animals are essential genetic tools in scientific research and global resources in agriculture. In both arenas, a single sex is often required in surplus. The ethical and financial burden of producing and culling animals of the undesired sex is consi
Publikováno v:
Development. 147
[Graphic][1] Paul Burgoyne was an outstanding mouse geneticist and developmental biologist who made fundamental discoveries about the sex chromosomes and their biology. He was born on 10th January 1946, spending most of his childhood living in Dartmo
Autor:
Gregorio Alanis-Lobato, Leila Christie, Rebecca A. Lea, Claudia Gerri, Phil Snell, Lyn Healy, Kathy K. Niakan, Miriam Molina-Arcas, Afshan McCarthy, Katarzyna J. Grybel, Julian Downward, Sugako Ogushi, Sissy E. Wamaitha, Shantha K. Mahadevaiah, Liani G. Devito, James M. A. Turner, Kay Elder
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Our understanding of the signalling pathways regulating early human development is limited, despite their fundamental biological importance. Here, we mine transcriptomics datasets to investigate signalling in the human embryo and identify expression