Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Shantanu Sule"'
Autor:
Craig Duane Dickinson, Shantanu Sule, Steven B. Geng, Qing Chai, Peter M. Tessier, Caroline Weldon, Jiemin Wu, Jason S. Schultz
Publikováno v:
Protein Engineering Design and Selection. 28:403-414
Self-association of monoclonal antibodies (mAbs) at high concentrations can result in developability challenges such as poor solubility, aggregation, opalescence and high viscosity. There is a significant unmet need for methods that can evaluate self
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f36aa30f3ab0a07125229dfed6d796
https://doi.org/10.1093/protein/gzv045
https://doi.org/10.1093/protein/gzv045
Autor:
Shantanu Sule, Suli Liu, Vincent J. Mecozzi, Allan D. Capili, William C. Yang, Kapil Gupta, Jason E. Fernandez, Li Zang, Tia Estey, Pamela Feng, Yana Kravets
Publikováno v:
Journal of pharmaceutical sciences. 106(12)
Characterizing molecular charge variants or isoforms is essential for understanding safety, potency, and bioavailability of antibody therapeutics. However, there is little information on how they influence stability and viscosity-properties governing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2002f468ca1dfbec083b082cff538e70
https://pubmed.ncbi.nlm.nih.gov/28860086
https://pubmed.ncbi.nlm.nih.gov/28860086
Autor:
Steven J. Blaisdell, Valentyn Antochshuk, Mohammed Shameem, Peter M. Tessier, Chakravarthy Nachu Narasimhan, Jason K. Cheung, Shantanu Sule, Amardeep Bhalla
Publikováno v:
Molecular Pharmaceutics. 9:744-751
Monoclonal antibodies display highly variable solution properties such as solubility and viscosity at elevated concentrations (50 mg/mL), which complicates antibody formulation and delivery. To understand this complex behavior, it is critical to meas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca4166f425678a0cb2badd73f7c355ce
https://doi.org/10.1021/mp200448j
https://doi.org/10.1021/mp200448j
Autor:
Muppalla Sukumar, Peter M. Tessier, Anna Marie Marcelino-Cruz, Shantanu Sule, William F. Weiss, Tyler Sample
Publikováno v:
Biophysical Journal. 101(7):1749-1757
Monoclonal antibodies are typically monomeric and nonviscous at low concentrations, yet they display highly variable associative and viscous behavior at elevated concentrations. Although measurements of antibody self-association are critical for unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7204a7d528880cccee4b8e4bc2a5102