Discovery of potent tubulin inhibitors targeting the colchicine binding site via structure-based lead optimization and antitumor evaluation

Autor: Wei Liu, Youyou He, Zhongjie Guo, Miaomiao Wang, Xiaodong Han, Hairui Jia, Jin He, Shanshan Miao, Shengzheng Wang

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)

The colchicine binding site of tubulin is a promising target for discovering novel antitumour agents. Previously, we identified 2-aryl-4-amide-quinoline derivatives displayed moderate tubulin polymerisation inhibitory activity and broad-spectrum in v

Externí odkaz: https://doaj.org/article/1ee17a3b8c554a94a78f1efbb7b57ebb

Deeds and Words : Farmers’ Attitude-Paradox in Collective Action for Small-Scale Irrigation

Autor: Shanshan Miao, Xueqin Zhu, Wim Heijman, Zengwei Xu, Qian Lu

Publikováno v: International Journal of Environmental Research and Public Health; Volume 20; Issue 1; Pages: 549
International Journal of Environmental Research and Public Health, 20(1)
International Journal of Environmental Research and Public Health 20 (2023) 1

We explore the mechanisms of the attitude–behavior paradox and how multiple stakeholders strategize to compromise their attitudes and behaviors. Through an instrumental variable probit model, we examine the effect of income heterogeneity and social

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cac81477eff7b275e4ab64f01d45a489
https://doi.org/10.3390/ijerph20010549

Solubility and Physical Properties of α-Calcium Sulfate Hemihydrate in NaCl and Glycerol Aqueous Solutions at 303.15, 323.15, and 343.15 K

Autor: Bingjie Yu, Shanshan Miao, Manxin Ding, Yongsheng Ren

Publikováno v: Journal of Chemical & Engineering Data. 66:3686-3694

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5415b83a3fc281f0e289ea8c6ff3a9e9
https://doi.org/10.1021/acs.jced.1c00214

Enzymatic esterification of lauric acid to give monolaurin in a microreactor

Autor: Shanshan Miao, Xin Li

Publikováno v: Journal of Chemical Research. 45:660-667

Monolaurin is a naturally occurring compound widely utilized in food and cosmetics. In this paper, we present a new method for the synthesis of monolaurin by esterification between lauric acid and glycerol catalyzed by Novozym® 435 using a microreac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05598e9d705c4bfa28ca550d4e2bf9b0
https://doi.org/10.1177/1747519820977164

Determination and Analysis of the Solubility of CaSO4·2H2O and α-CaSO4·0.5H2O in Formamide Aqueous Solutions at T = 303.15–363.15 K

Autor: Yujia Zhang, Yongsheng Ren, Shanshan Miao, Bingjie Yu

Publikováno v: Journal of Chemical & Engineering Data. 65:4395-4405

The solubility of calcium sulfate dihydrate (DH) and α-calcium sulfate hemihydrate in formamide aqueous solutions with 0–13 m formamide at temperatures from 303.15 to 363.15 K was measured by the d...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::444632511ea980f1cb0a0acd32d45287
https://doi.org/10.1021/acs.jced.0c00205