Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Shannon X. Zhao"'
Autor:
Li Sha, Kerry E. Murphy-Benenato, Frank Wu, Thomas F. Durand-Reville, Haris Jahic, Hajnalka E. Davis, Ning Gao, Mark Sylvester, Shannon X. Zhao, Olga Quiroga, Erika L. Manyak, Michael T. Rooney, John P. Mueller, Brian Dangel, Andrew D. Ferguson, Mark Zambrowski
A main challenge in the development of new agents for the treatment of Pseudomonas aeruginosa infections is the identification of chemotypes that efficiently penetrate the cell envelope and are not susceptible to established resistance mechanisms. Si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::250216b54c9993a14170a724d0151038
https://europepmc.org/articles/PMC4434466/
https://europepmc.org/articles/PMC4434466/
Autor:
David E. Ehmann, Mark Zambrowski, Adam B. Shapiro, Pratik R. Bhagunde, Beesan Tan, Kerry E. Murphy-Benenato, Li Sha, Olga Quiroga, Vincent Galullo, Hajnalka E. Davis, M. R. Manjunatha, Holia Hatoum-Mokdad, Mark Sylvester, Aryun Kim, Haris Jahic, Shannon X. Zhao, Ye Wu, April Chen, Andy S. Tsai, Jennifer J. Harris, Sara A. Patey, Michael T. Rooney, Erika L. Manyak, Thomas F. Durand-Reville, Maria Uria-Nickelsen, John P. Mueller
Publikováno v:
Journal of medicinal chemistry. 58(5)
To identify new agents for the treatment of multi-drug-resistant Pseudomonas aeruginosa, we focused on siderophore-conjugated monocarbams. This class of monocyclic β-lactams are stable to metallo-β-lactamases and have excellent P. aeruginosa activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9c8bc8fc6fed09ccc99de4eda7e65b
https://pubmed.ncbi.nlm.nih.gov/25658376
https://pubmed.ncbi.nlm.nih.gov/25658376
Publikováno v:
Tetrahedron Letters. 41:4011-4014
Functionalized 2,3-dihydrobenzofuran can be synthesized in good yield via an intramolecular cyclization of an aryl chloride and a primary alcohol under the catalysis of copper(I) chloride salt.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e35f934f5c14b1746ccb2bf06d3dec4d
https://doi.org/10.1016/s0040-4039(00)00548-7
https://doi.org/10.1016/s0040-4039(00)00548-7
Publikováno v:
Tetrahedron Letters. 46:2795-2797
Under heterogeneous catalysis, ethyl 2-amino-2-difluoromethyl-4-cyanobutanoate or its Schiff base could be selectively reduced in good yield by hydrogenation to give a diamine, or to form a five-membered ring or a six-membered ring heterocycles. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14ac5429a0af7dbb5e8a50b3265915c0
https://doi.org/10.1016/j.tetlet.2005.02.146
https://doi.org/10.1016/j.tetlet.2005.02.146
Publikováno v:
Tetrahedron Letters. 43:7585-7587
A method of synthesizing optically pure (S)-2-acetylthio-3-benzenepropanoic acid has been developed and good to excellent enantiomeric excess achieved via enzymatic resolution.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdccc03dc78a8227f71efe3a43cfb2cb
https://doi.org/10.1016/s0040-4039(02)01820-8
https://doi.org/10.1016/s0040-4039(02)01820-8
Autor:
Madhusudhan Reddy Gowravaram, Shannon X. Zhao, Robert Albert, George B. Mullen, Jenna Harang, Marta Cavero-Tomas, Scott D. Mills, Suzanne Stokes, Brendan Chen, Ce-Feng Liu, Hoan Huynh, Min Lu, James T. Loch
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(15)
Optimization of adenosine analog inhibitors of bacterial NAD(+)-dependent DNA ligase is discussed. Antibacterial activity against Streptococcus pneumoniae and Staphylococcus aureus was improved by modification of the 2-position substituent on the ade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc4ee6f3599f3d60296bda6b3a7eeb77
https://pubmed.ncbi.nlm.nih.gov/21719282
https://pubmed.ncbi.nlm.nih.gov/21719282
Publikováno v:
ChemInform. 31
Functionalized 2,3-dihydrobenzofuran can be synthesized in good yield via an intramolecular cyclization of an aryl chloride and a primary alcohol under the catalysis of copper(I) chloride salt.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91d9ef795329b01ec43649789c52ae98
https://doi.org/10.1002/chin.200036116
https://doi.org/10.1002/chin.200036116