Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Shannon R. Fix-Stenzel"'
1
Discovery of thieno[2,3-c]pyridines as potent COT inhibitors
Autor: Jose-Andres Salmeron, Kevin P. Cusack, Dawn M. George, Thomas D. Gordon, Michael Friedman, Bernd Janssen, Agnieszka Bischoff, Claude Barberis, Woller Kevin R, Yong Jia, Neil Wishart, Shannon R. Fix-Stenzel, Richard W. Dixon, Christopher Quinn, Maria A. Argiriadi, Zhengtian Yu, Anca Clabbers, Hamish Allen, Maria D Moskey
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 18:4952-4955
Evaluation of hit chemotypes from high throughput screening identified a novel series of 2,4-disubstituted thieno[2,3-c]pyridines as COT kinase inhibitors. Structural modifications exploring SAR at the 2- and 4-positions resulting in inhibitors with
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf9f19003a922c321db0fa9412b49ff
https://doi.org/10.1016/j.bmcl.2008.08.037
Zobrazit plný text záznamu
2
A stereoselective and scalable synthesis of a conformationally constrained S1P1 agonist
Autor: Pintipa Grongsaard, Steven M. Hannick, Thaddeus S. Franczyk, Shannon R. Fix-Stenzel, Lisa M. Schaffter, Grier A. Wallace, Robert H. Stoffel, Martin E. Hayes, Kevin P. Cusack, Xiaolei Zhang
Publikováno v: Tetrahedron Letters. 50:4081-4083
A scalable and enantioselective synthesis of a potent S1P1 agonist containing two stereogenic centers on a cyclopentane ring is described. Control of the absolute chirality of an amino alcohol precursor, generated via a robust phase-transfer catalyze
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::322f677b3d45378cc9c983b66bef5455
https://doi.org/10.1016/j.tetlet.2009.04.099
Zobrazit plný text záznamu
3
Scalable synthesis and isolation of the four stereoisomers of methyl 1-amino-3-(4-bromophenyl)cyclopentanecarboxylate, useful intermediates for the synthesis of S1P1 receptor agonists
Autor: Lisa M. Schaffter, Martin E. Hayes, Robert H. Stoffel, Grier A. Wallace, Donald B. Konopacki, Thomas D. Gordon, Pintipa Grongsaard, Shannon R. Fix-Stenzel, Kevin P. Cusack, Xiaolei Zhang, Rodger F. Henry
Publikováno v: The Journal of organic chemistry. 74(13)
The individual isomers of methyl 1-amino-3-(4-bromophenyl)cyclopentanecarboxylate are useful intermediates for the synthesis of S1P1 receptor agonists. Herein we describe a scalable synthesis and isolation of each of the four stereoisomers of this co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7f5e7584e090828168f6ddee1613dc1
https://pubmed.ncbi.nlm.nih.gov/19489574
Zobrazit plný text záznamu
4
Identification of a selective thieno[2,3-c]pyridine inhibitor of COT kinase and TNF-alpha production
Autor: Pintipa Grongsaard, Yong Jia, Andres Salmeron, Christine M. Thomas, Richard W. Dixon, Grier A. Wallace, Michael Friedman, Dawn M. George, Hamish Allen, Agnieszka Bischoff, Zhengtian Yu, Thomas D. Gordon, Bernd Janssen, Maria D Moskey, Shannon R. Fix-Stenzel, Christopher Quinn, Yvette Gaumont, Kevin P. Cusack, Neil Wishart, Anca Clabbers
Publikováno v: Bioorganicmedicinal chemistry letters. 19(6)
COT (Tpl2 in mice) is a serine/threonine MAP3 kinase that regulates production of TNF-alpha and other pro-inflammatory cytokines such as IL-1beta via the ERK/MAP kinase pathway. As TNF-alpha and IL-1beta are clinically validated targets for therapeut
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f181a4a20bde9e1eb2381df4be8001
https://pubmed.ncbi.nlm.nih.gov/19217782
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje