Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Shannon R. Fix"'
Autor:
Jose-Andres Salmeron, Kevin P. Cusack, Dawn M. George, Thomas D. Gordon, Michael Friedman, Bernd Janssen, Agnieszka Bischoff, Claude Barberis, Woller Kevin R, Yong Jia, Neil Wishart, Shannon R. Fix-Stenzel, Richard W. Dixon, Christopher Quinn, Maria A. Argiriadi, Zhengtian Yu, Anca Clabbers, Hamish Allen, Maria D Moskey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4952-4955
Evaluation of hit chemotypes from high throughput screening identified a novel series of 2,4-disubstituted thieno[2,3-c]pyridines as COT kinase inhibitors. Structural modifications exploring SAR at the 2- and 4-positions resulting in inhibitors with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf9f19003a922c321db0fa9412b49ff
https://doi.org/10.1016/j.bmcl.2008.08.037
https://doi.org/10.1016/j.bmcl.2008.08.037
Autor:
Pintipa Grongsaard, Steven M. Hannick, Thaddeus S. Franczyk, Shannon R. Fix-Stenzel, Lisa M. Schaffter, Grier A. Wallace, Robert H. Stoffel, Martin E. Hayes, Kevin P. Cusack, Xiaolei Zhang
Publikováno v:
Tetrahedron Letters. 50:4081-4083
A scalable and enantioselective synthesis of a potent S1P1 agonist containing two stereogenic centers on a cyclopentane ring is described. Control of the absolute chirality of an amino alcohol precursor, generated via a robust phase-transfer catalyze
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::322f677b3d45378cc9c983b66bef5455
https://doi.org/10.1016/j.tetlet.2009.04.099
https://doi.org/10.1016/j.tetlet.2009.04.099
Publikováno v:
Tetrahedron Letters. 40:6705-6708
Benzoboroxoles (5) can be prepared from the readily available o-bromobenzyl alcohols via dilithiation followed by reaction with triisopropylborate. X-Ray structural analysis of 1-hydroxy-3(1H)-1,2-benzoboroxole (5a) as well as the results of ab initi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::addd8ae6d1e0bd51e165f0b7d8acda31
https://doi.org/10.1016/s0040-4039(99)01303-9
https://doi.org/10.1016/s0040-4039(99)01303-9
Publikováno v:
Angewandte Chemie. 114:172-174
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6560c9c8e4457248ef93a69fda13d1ab
https://doi.org/10.1002/1521-3757(20020104)114:1<172::aid-ange172>3.0.co
https://doi.org/10.1002/1521-3757(20020104)114:1<172::aid-ange172>3.0.co
Publikováno v:
ChemInform. 30
Benzoboroxoles (5) can be prepared from the readily available o-bromobenzyl alcohols via dilithiation followed by reaction with triisopropylborate. X-Ray structural analysis of 1-hydroxy-3(1H)-1,2-benzoboroxole (5a) as well as the results of ab initi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5ab9af361c99e3955a1e471f83b0c6f
https://doi.org/10.1002/chin.199947179
https://doi.org/10.1002/chin.199947179
Publikováno v:
ChemInform. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0fbb76bc02209197e1a27647ec71d78
https://doi.org/10.1002/chin.200224123
https://doi.org/10.1002/chin.200224123
Autor:
Lisa M. Schaffter, Martin E. Hayes, Robert H. Stoffel, Grier A. Wallace, Donald B. Konopacki, Thomas D. Gordon, Pintipa Grongsaard, Shannon R. Fix-Stenzel, Kevin P. Cusack, Xiaolei Zhang, Rodger F. Henry
Publikováno v:
The Journal of organic chemistry. 74(13)
The individual isomers of methyl 1-amino-3-(4-bromophenyl)cyclopentanecarboxylate are useful intermediates for the synthesis of S1P1 receptor agonists. Herein we describe a scalable synthesis and isolation of each of the four stereoisomers of this co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7f5e7584e090828168f6ddee1613dc1
https://pubmed.ncbi.nlm.nih.gov/19489574
https://pubmed.ncbi.nlm.nih.gov/19489574
Identification of a selective thieno[2,3-c]pyridine inhibitor of COT kinase and TNF-alpha production
Autor:
Pintipa Grongsaard, Yong Jia, Andres Salmeron, Christine M. Thomas, Richard W. Dixon, Grier A. Wallace, Michael Friedman, Dawn M. George, Hamish Allen, Agnieszka Bischoff, Zhengtian Yu, Thomas D. Gordon, Bernd Janssen, Maria D Moskey, Shannon R. Fix-Stenzel, Christopher Quinn, Yvette Gaumont, Kevin P. Cusack, Neil Wishart, Anca Clabbers
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(6)
COT (Tpl2 in mice) is a serine/threonine MAP3 kinase that regulates production of TNF-alpha and other pro-inflammatory cytokines such as IL-1beta via the ERK/MAP kinase pathway. As TNF-alpha and IL-1beta are clinically validated targets for therapeut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50f181a4a20bde9e1eb2381df4be8001
https://pubmed.ncbi.nlm.nih.gov/19217782
https://pubmed.ncbi.nlm.nih.gov/19217782
Autor:
David G. Witte, Brian M. Bettencourt, Irene Drizin, Jill M. Wetter, Huaqing Liu, Thomas R. Miller, Timothy A. Esbenshade, Robert J. Altenbach, Jorge D. Brioni, Shannon R. Fix-Stenzel, Prisca Honore, James P. Sullivan, Ronald M. Adair, Ivan Milicic, Mcpherson Michael J, Kennan C. Marsh, Gin C. Hsieh, Marlon D. Cowart, Neil Wishart
Publikováno v:
Journal of medicinal chemistry. 51(20)
A new structural class of histamine H 4 receptor antagonists (6-14) was designed based on rotationally restricted 2,4-diaminopyrimidines. Series compounds showed potent and selective in vitro H 4 antagonism across multiple species, good CNS penetrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546be6d2b96cd1a705e41035d0bad72e
https://pubmed.ncbi.nlm.nih.gov/18817367
https://pubmed.ncbi.nlm.nih.gov/18817367
Publikováno v:
Angewandte Chemie (International ed. in English). 41(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b15d5d6b56624fb48835b2dec940f12a
https://pubmed.ncbi.nlm.nih.gov/12491473
https://pubmed.ncbi.nlm.nih.gov/12491473