Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Shannon P Fortin Ensign"'
Autor:
Holly M Thomson, Shannon P Fortin Ensign, Victoria S Edmonds, Akanksha Sharma, Richard J Butterfield, Steven E Schild, Jonathan B Ashman, Richard S Zimmerman, Naresh P Patel, Alan H Bryce, Sujay A Vora, Terence T Sio, Alyx B Porter
Publikováno v:
Clinical Medicine Insights: Oncology, Vol 17 (2023)
Background: Radiation necrosis (RN) is a clinically relevant complication of stereotactic radiosurgery (SRS) for intracranial metastasis (ICM) treatments. Radiation necrosis development is variable following SRS. It remains unclear if risk factors fo
Externí odkaz:
https://doaj.org/article/48a5805074b749edbe98ab54b51bf596
Publikováno v:
Current Problems in Cancer: Case Reports, Vol 4, Iss , Pp 100103- (2021)
Leptomeningeal disease remains a marker of poor prognosis for patients with metastatic spread of solid tumors. Treatment options are limited and often poorly tolerated. Here we report a case of the first in human intrathecal administration of the PD-
Externí odkaz:
https://doaj.org/article/7e9f5048b2ef45e78435fc2ae05e4dd7
Autor:
Shannon P. Fortin Ensign, Charles Gaulin, Maya Hrachova, Michael Ruff, Ehab Harahsheh, Kevin Vicenti, Januario Castro, Javier Munoz, Allison Rosenthal, Maciej M. Mrugala
Publikováno v:
Current Treatment Options in Oncology. 23:1845-1860
Chimeric antigen receptor (CAR) T-cells are now a well-established treatment for hematologic malignancies. Their use in clinical practice has expanded quite rapidly and hospitals have developed CAR T-cell protocols to evaluate patients for associated
Autor:
Shannon P Fortin Ensign, Robert B Jenkins, Caterina Giannini, Jann N Sarkaria, Evanthia Galanis, Sani H Kizilbash
Publikováno v:
Neuro-Oncology. 25:28-36
Isocitrate dehydrogenase (IDH) 1 or 2 mutations confer a favorable prognosis compared to IDH-wildtype in astrocytoma, frequently denoting a lower grade malignancy. However, recent molecular profiling has identified specific aggressive tumor subgroups
Autor:
Nhan L. Tran, Michael E. Berens, Joseph C. Loftus, Marc H. Symons, Jann N. Sarkaria, Serdar Tuncali, Harshil D. Dhruv, Ian T. Mathews, Alison Roos, Shannon P. Fortin Ensign
Supplementary Figure 6. SGEF protein levels across a panel of primary parental versus TMZ-R xenografts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a4611b39fd6f3970f0abc32476f9187
https://doi.org/10.1158/1541-7786.22511431
https://doi.org/10.1158/1541-7786.22511431
Autor:
Nhan L. Tran, Michael E. Berens, Joseph C. Loftus, Marc H. Symons, Jann N. Sarkaria, Serdar Tuncali, Harshil D. Dhruv, Ian T. Mathews, Alison Roos, Shannon P. Fortin Ensign
Glioblastoma (GB) is the highest grade and most common form of primary adult brain tumors. Despite surgical removal followed by concomitant radiation and chemotherapy with the alkylating agent temozolomide, GB tumors develop treatment resistance and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::391a81596584efe054a2285399ced34c
https://doi.org/10.1158/1541-7786.c.6539941.v1
https://doi.org/10.1158/1541-7786.c.6539941.v1
Autor:
Nhan L. Tran, Michael E. Berens, Joseph C. Loftus, Marc H. Symons, Jann N. Sarkaria, Serdar Tuncali, Harshil D. Dhruv, Ian T. Mathews, Alison Roos, Shannon P. Fortin Ensign
Supplementary Figure 1. Depletion of SGEF expression does not alter glioma cell proliferation or cell cycle.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f6af9b553a070be890d5ac78ce4e604
https://doi.org/10.1158/1541-7786.22511446
https://doi.org/10.1158/1541-7786.22511446
Autor:
Nhan L. Tran, Michael E. Berens, Joseph C. Loftus, Marc H. Symons, Jann N. Sarkaria, Serdar Tuncali, Harshil D. Dhruv, Ian T. Mathews, Alison Roos, Shannon P. Fortin Ensign
Supplementary Figure 4. TMZ treatment induces nuclear RhoG activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f9f16a3e56a257bb187dea79f8f9bcd
https://doi.org/10.1158/1541-7786.22511437
https://doi.org/10.1158/1541-7786.22511437
Autor:
Nhan L. Tran, Michael E. Berens, Joseph C. Loftus, Marc H. Symons, Jann N. Sarkaria, Serdar Tuncali, Harshil D. Dhruv, Ian T. Mathews, Alison Roos, Shannon P. Fortin Ensign
Supplementary Figure 5. SGEF is required for BRCA1 recruitment to H2A.X foci following TMZ treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230ece439a8842343af6bc70b9c47892
https://doi.org/10.1158/1541-7786.22511434
https://doi.org/10.1158/1541-7786.22511434
Autor:
Nhan L. Tran, Michael E. Berens, Joseph C. Loftus, Marc H. Symons, Jann N. Sarkaria, Serdar Tuncali, Harshil D. Dhruv, Ian T. Mathews, Alison Roos, Shannon P. Fortin Ensign
Supplementary Figure 3. SGEF depletion in glioma cells display impaired DNA double strain break repair kinetics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd573bb69756c7e9edee3f69252b2670
https://doi.org/10.1158/1541-7786.22511440
https://doi.org/10.1158/1541-7786.22511440