Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Shannon O. Harris"'
Autor:
Emily D. Burwell, Mark R. Yarolimek, Michael Hambourger, Shannon O. Harris, Ambre E. Chiomento, Kyle J. Demsko, Zachary H. Williams, Jacob T. Pawlik, Megan B. Whitney, Alexander D. Schwab
Publikováno v:
Soft matter. 13(37)
2,2′-Bipyridine-terminated poly(dimethylsiloxane)s (bpyPDMS) with number average molecular weights, MN, of 3300, 6100, 26 200, and 50 000 g mol−1 were synthesized. When mixed with Fe(BF4)2 at low concentrations, red solutions formed with UV-vis s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84929d219963d44abf3f8a39288b68c9
https://pubmed.ncbi.nlm.nih.gov/28895607
https://pubmed.ncbi.nlm.nih.gov/28895607
Autor:
Willard Lew, Ute Hoch, Jeffrey A. Silverman, Stacey A. Heumann, Sheryl N. Ivy, Stuart Lam, Minna Bui, Hanan Emily, Thomas O'Brien, W. Michael Flanagan, Robert A. Elling, Bradley T. Tangonan, Hans E. Purkey, Heman Lee, Min Zhong, Subramanian Baskaran, Kristin M. Zimmerman, Pietro Taverna, Robert S. McDowell, Amy D. Fung, Wang Shen, Shannon O. Harris, Michael J. Romanowski, Wenjin Yang, Jeffrey W. Jacobs, Joshua C. Yoburn, Darin Allen, Chul Yu, Johan D. Oslob
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5158-5161
This Letter describes the discovery and key structure-activity relationship (SAR) of a series of 2-aminobenzimidazoles as potent Aurora kinase inhibitors. 2-Aminobenzimidazole serves as a bioisostere of the biaryl urea residue of SNS-314 (1c), which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e3f97920374b8e6e5f11cd9c42ab0bc
https://doi.org/10.1016/j.bmcl.2009.07.016
https://doi.org/10.1016/j.bmcl.2009.07.016
Autor:
Jeffrey W. Jacobs, Shannon O. Harris, W. Michael Flanagan, Joni W. Lam, Ute Hoch, Sean Ritchie, Raymond V. Fucini, Stig Hansen, Marc J. Evanchik, David E. Stockett, Brian J. Belmont, Jeffrey A. Silverman, Kristin M. Zimmerman, Hashash Ahmad, Pietro Taverna, Jennifer N. Hogan, Juli N. Teague, Jennifer P. Arbitrario, Anthony Howlett, Michael J. Romanowski
Publikováno v:
Cancer Chemotherapy and Pharmacology. 65:707-717
The Aurora family of serine/threonine kinases (Aurora-A, Aurora-B, and Aurora-C) plays a key role in cells orderly progression through mitosis. Elevated expression levels of Aurora kinases have been detected in a high percentage of melanoma, colon, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f55f64b155510603db6969a00c09da
https://doi.org/10.1007/s00280-009-1076-8
https://doi.org/10.1007/s00280-009-1076-8
Autor:
Shannon O. Harris, Stacey A. Heumann, Jeffrey W. Jacobs, William Michael Flanagan, Subramanian Baskaran, Kristin M. Zimmerman, Darin Allen, Minna Bui, Michael J. Romanowski, Bradley T. Tangonan, Johan D. Oslob, Robert S. McDowell, Wang Shen, Chris E Lawrence, Juli N. Teague, Willard Lew, Michelle M. Sopko, Michelle A. Nannini, Jeffrey A. Silverman, Joshua C. Yoburn, Chul Yu, Min Zhong, Hanan Emily, Ute Hoch, Amy D. Fung, Joni Lam, Robert A. Elling, Thomas O'Brien
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(17)
This communication describes the discovery of a novel series of Aurora kinase inhibitors. Key SAR and critical binding elements are discussed. Some of the more advanced analogues potently inhibit cellular proliferation and induce phenotypes consisten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6628e44d37788613c268d76ba8583b8
https://pubmed.ncbi.nlm.nih.gov/18678489
https://pubmed.ncbi.nlm.nih.gov/18678489