Translational profiling of dorsal root ganglia and spinal cord in a mouse model of neuropathic pain

Autor: Sonali Uttam, Calvin Wong, Inês S. Amorim, Seyed Mehdi Jafarnejad, Shannon N. Tansley, Jieyi Yang, Masha Prager-Khoutorsky, Jeffrey S. Mogil, Christos G. Gkogkas, Arkady Khoutorsky

Publikováno v: Neurobiology of Pain, Vol 4, Iss , Pp 35-44 (2018)

Acute pain serves as a protective mechanism, guiding the organism away from actual or potential tissue injury. In contrast, chronic pain is a debilitating condition without any obvious physiological function. The transition to, and the maintenance of

Externí odkaz: https://doaj.org/article/f350ac7b5d1c408188a59b41101b6490

Genetic pathway analysis reveals a major role for extracellular matrix organization in inflammatory and neuropathic pain

Autor: Marjo Piltonen, Shannon N Tansley, Loren J. Martin, Concetta Dagostino, Massimo Allegri, Luda Diatchenko, Nehme El-Hachem, Marc Parisien, Jeffrey S. Mogil, Arkady Khoutorsky, Alexander Samoshkin

Publikováno v: Pain. 160:932-944

Chronic pain is a debilitating and poorly treated condition whose underlying mechanisms are poorly understood. Nerve injury and inflammation cause alterations in gene expression in tissues associated with pain processing, supporting molecular and cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26febaf139eb3c74df67aea190263e2d
https://doi.org/10.1097/j.pain.0000000000001471

4E-BP2-dependent translation in parvalbumin neurons controls epileptic seizure threshold

Autor: Jean-Claude Lacaille, Danning Lou, Peng Wang, Maxime Lévesque, Jeremy Y. Levett, Yelin Han, Kobi Rosenblum, Shravan Murthy, Siyan Wang, Rapita Sood, Soroush Tahmasebi, Nadeem Siddiqui, Massimo Avoli, Nahum Sonenberg, Vijendra Sharma, Shannon N Tansley, Arkady Khoutorsky, Tzu-Yu Hung

Publikováno v: Proc Natl Acad Sci U S A

The mechanistic/mammalian target of rapamycin complex 1 (mTORC1) integrates multiple signals to regulate critical cellular processes such as mRNA translation, lipid biogenesis, and autophagy. Germline and somatic mutations in mTOR and genes upstream

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a7e16ba4a7950ced3389a0c4269010
https://pubmed.ncbi.nlm.nih.gov/33876772

Genome-wide association reveals contribution of MRAS to painful temporomandibular disorder in males

Autor: Priscila de Oliveira Serrano, Shannon N Tansley, Nadia Laniado, Anne Julie Chabot-Doré, Gary D. Slade, Raija Lähdesmäki, Cecelia A. Laurie, Joel D. Greenspan, Deepti Jain, Richard H. Gracely, Richard Ohrbach, Olaf Bernhardt, Andrea G. Nackley, Margarete C. Ribeiro-Dasilva, Kirsi Sipilä, Célia Marisa Rizzatti-Barbosa, Pavel Gris, Samar Khoury, Carolina B. Meloto, Christian Schwahn, Cathy C. Laurie, Jeffrey S. Mogil, Alexander Teumer, Inna Belfer, Linda M. Kaste, William Maixner, Roger B. Fillingim, Shad B. Smith, Yelizaveta Torosyan, Sarah C. Nelson, Marjo-Riitta Järvelin, Luda Diatchenko, Tamar Sofer, Minna Männikkö, Dmitri V. Zaykin, Thomas Kocher, Kathleen F. Kerr, Eric Bair, Marc Parisien, Paula Pesonen, Anne E. Sanders

Publikováno v: Pain

Supplemental Digital Content is Available in the Text. A polymorphic locus associated with a protective effect against painful temporomandibular disorder in males regulates the expression of the muscle RAS oncogene homolog (MRAS) gene.
Painful t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8482d3d9c76804794b562983d056705c
https://pubmed.ncbi.nlm.nih.gov/30431558

Social propinquity in rodents as measured by tube cooccupancy differs between inbred and outbred genotypes

Autor: Alexander H. Tuttle, Tine Pooters, Kimberly Dossett, Oliver Hardt, Melissa Sukosd, Jean-Sebastien Austin, Hayley Crawhall-Duk, Arkady Khoutorsky, Liane Stein, Christos G. Gkogkas, Lindsey Gerstein, Nahum Sonenberg, Isabelle A. Groves, Sioui Maldonado-Bouchard, Loren J. Martin, Rebecca Pearl, Sarasa Tohyama, Claire M Chan, Philip Leger, Shannon N Tansley, Jeffrey S. Mogil, David Yachnin

Publikováno v: Tuttle, A H, Tansley, S, Dossett, K, Tohyama, S, Khoutorsky, A, Maldonado-Bouchard, S, Stein, L, Gerstein, L, Crawhall-Duk, H, Pearl, R, Sukosd, M, Leger, P, Hardt, O M, Yachnin, D, Austin, J-S, Chan, C M, Pooters, T, Groves, I, Martin, L J, Sonenberg, N, Gkogkas, C G & Mogil, J S 2017, ' Social propinquity in rodents as measured by tube cooccupancy differs between inbred and outbred genotypes ', Proceedings of the National Academy of Sciences, vol. 114, no. 21, pp. 5515-5520 . https://doi.org/10.1073/pnas.1703477114

Existing assays of social interaction are suboptimal, and none measures propinquity, the tendency of rodents to maintain close physical proximity. These assays are ubiquitously performed using inbred mouse strains and mutations placed on inbred genet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa70e8397f90e7c0b890a798fb2edbb9
https://hdl.handle.net/20.500.11820/48515228-1642-4734-8c8c-305b6193eec1