Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Shannon M. White"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
It remains unclear how spontaneous Pancreatic Ductal Adenocarcinoma (PDAC) tumors escape Yap dependency. Here, the authors show that lineage plasticity promotes spontaneous relapse following YAP ablation and reveal key transcriptional drivers that ov
Externí odkaz:
https://doaj.org/article/df63191ad5df4c8da8cf9519ea7988c1
Autor:
Graham S. Erwin, Gamze Gürsoy, Rashid Al-Abri, Ashwini Suriyaprakash, Egor Dolzhenko, Kevin Zhu, Christian R. Hoerner, Shannon M. White, Lucia Ramirez, Ananya Vadlakonda, Alekhya Vadlakonda, Konor von Kraut, Julia Park, Charlotte M. Brannon, Daniel A. Sumano, Raushun A. Kirtikar, Alicia A. Erwin, Thomas J. Metzner, Ryan K. C. Yuen, Alice C. Fan, John T. Leppert, Michael A. Eberle, Mark Gerstein, Michael P. Snyder
Publikováno v:
Nature. 613:96-102
Expansion of a single repetitive DNA sequence, termed a tandem repeat (TR), is known to cause more than 50 diseases1,2. However, repeat expansions are often not explored beyond neurological and neurodegenerative disorders. In some cancers, mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0960ace30a01bc4fd6356079f51ab7f5
https://doi.org/10.1038/s41586-022-05515-1
https://doi.org/10.1038/s41586-022-05515-1
Publikováno v:
Nucleic Acids Research
The term ‘super enhancers’ (SE) has been widely used to describe stretches of closely localized enhancers that are occupied collectively by large numbers of transcription factors (TFs) and co-factors, and control the transcription of highly-expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68eb404674a0e43ca61111baf617b395
https://doi.org/10.1093/nar/gkab1105
https://doi.org/10.1093/nar/gkab1105
Autor:
Graham S. Erwin, Gamze Gürsoy, Rashid Al-Abri, Ashwini Suriyaprakash, Egor Dolzhenko, Kevin Zhu, Christian R. Hoerner, Shannon M. White, Lucia Ramirez, Ananya Vadlakonda, Alekhya Vadlakonda, Konor von Kraut, Julia Park, Charlotte M. Brannon, Daniel A. Sumano, Raushun A. Kirtikar, Alicia A. Erwin, Thomas J. Metzner, Ryan K. C. Yuen, Alice C. Fan, John T. Leppert, Michael A. Eberle, Mark Gerstein, Michael P. Snyder
Expansion of a single repetitive DNA sequence, termed a tandem repeat (TR), is known to cause more than 50 diseases. However, repeat expansions are often not explored beyond neurological and neurodegenerative disorders. In some cancers, mutations acc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b28dfefa141fa3a5614983f37cbddbe3
https://doi.org/10.1101/2022.08.24.505159
https://doi.org/10.1101/2022.08.24.505159
Publikováno v:
Journal of Environmental Management. 306:114386
Coastal management requires cost-effective, yet accurate, assessments of habitat condition, especially in areas protected by statutory conservation measures. Unmanned Aerial Vehicles (UAVs) provide alternatives to manned aircraft and walk-over (WO) s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e15862488912ae0e8c922114375521ea
https://doi.org/10.1016/j.jenvman.2021.114386
https://doi.org/10.1016/j.jenvman.2021.114386
Autor:
Ivan Nemazanyy, Chan D.K. Nguyen, Shigekazu Murakami, Chunling Yi, Shannon M. White, Hengye Chen, Mario Pende, Garrett T. Graham, Dieter Saur
Publikováno v:
Developmental Cell
Dev Cell
Dev Cell
Summary Employing inducible genetically engineered and orthotopic mouse models, we demonstrate a key role for transcriptional regulator Yap in maintenance of Kras-mutant pancreatic tumors. Integrated transcriptional and metabolomics analysis reveals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e21b40097ba5dcda382021a693f5315d
Autor:
Chunling Yi, Jeremie Vitte, Chan Nguyen, Yuhao Shi, Shannon M. White, Hengye Chen, Saumya R. Bollam, Jeffery A. Toretsky, Garrett T. Graham, Marco Giovannini, Mandheer Wadhwa, Sean Z. Laughlin
Publikováno v:
Developmental cell, vol 39, iss 4
Merlin encoded by the Nf2 gene is a bona fide tumor suppressor that has been implicated in regulation of both the Hippo-Yap and Rac1-Pak1 pathways. Using genetically engineered murine liver models, we show that co-deletion of Rac1 with Nf2 blocks tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c811fd1e4d302297e2598034d7cb143
https://doi.org/10.1016/j.devcel.2016.09.027
https://doi.org/10.1016/j.devcel.2016.09.027
Publikováno v:
Oncogene
The Hippo-Yap/Taz pathway, originally identified as a central developmental regulator of organ size, has been found perturbed in many types of human tumors, and linked to tumor growth, survival, evasion, metastasis, stemness, and drug resistance. Bes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc1e8733663a1a03c5635cdc16b963e
https://pubmed.ncbi.nlm.nih.gov/30617303
https://pubmed.ncbi.nlm.nih.gov/30617303
Autor:
Cristina Di Poto, Ivan Nemazanyy, Mario Pende, Geoffrey T. Gibney, Michael B. Atkins, Yang Yang, Habtom W. Ressom, Jeffery Field, Maria Laura Avantaggiati, Chunling Yi, Shannon M. White
Publikováno v:
Dev Cell
Merlin/NF2 is a bona fide tumor suppressor whose mutations underlie inherited tumor syndrome neurofibromatosis type 2 (NF2), as well as various sporadic cancers including kidney cancer. Multiple Merlin/NF2 effector pathways including the Hippo-YAP/TA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf9da82add597b11c76ddd28e1e989c7
https://pubmed.ncbi.nlm.nih.gov/31063758
https://pubmed.ncbi.nlm.nih.gov/31063758
Autor:
Rishi Surana, Hengye Chen, Garrett T. Graham, Shigekazu Murakami, Louis M. Weiner, Shannon M. White, W Zhang, Chunling Yi, David Shahbazian
Publikováno v:
Oncogene. 36(9)
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a high degree of inflammation and profound immune suppression. Here we identify Yes-associated protein (Yap) as a critical regulator of the immunosuppressive microenvironment in both mouse a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdaa7eb0d9266f556e2cdbe856a490cf
https://pubmed.ncbi.nlm.nih.gov/28839967
https://pubmed.ncbi.nlm.nih.gov/28839967