Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Shannon M. Ruppert"'
Autor:
Torben Plesner, Simon J. Harrison, Hang Quach, Cindy Lee, Adam Bryant, Annette Vangsted, Jane Estell, Michel Delforge, Fritz Offner, Patrick Twomey, Voleak Choeurng, Junyi Li, Robert Hendricks, Shannon M. Ruppert, Teiko Sumiyoshi, Karen Miller, Eunpi Cho, Fredrik Schjesvold
Publikováno v:
Clinical Hematology International, Vol 5, Iss 1, Pp 43-51 (2023)
Abstract Introduction This phase 1 trial assessed the safety, pharmacokinetics, and preliminary antitumor activity of RO7297089, an anti-BCMA/CD16a bispecific antibody. Methods RO7297089 was administered weekly by intravenous infusion to patients wit
Externí odkaz:
https://doaj.org/article/1e942104b3254806bc7d60bb7973e0d7
Autor:
David G. Coffey, Yuexin Xu, Andrea M. H. Towlerton, Marcin Kowanetz, Priti Hegde, Martine Darwish, Mahesh Yadav, Craig Blanchette, Shannon M. Ruppert, Sarah Bertino, Qikai Xu, Andrew Ferretti, Adam Weinheimer, Matthew Hellmann, Angel Qin, Dafydd Thomas, Edus H. Warren, Nithya Ramnath
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Most patients with advanced non-small cell lung cancer (NSCLC) do not achieve a durable remission after treatment with immune checkpoint inhibitors. Here we report the clinical history of an exceptional responder to radiation and anti-program death-l
Externí odkaz:
https://doaj.org/article/0ad62252e9ae47dfa7add7911dd39d72
Publikováno v:
International Journal of Cell Biology, Vol 2015 (2015)
Cyclosporine A (CSA) is an immunosuppressive agent that specifically targets T cells and also increases the percentage of pro-tolerogenic CD4+Foxp3+ regulatory T cells (Treg) through unknown mechanisms. We previously reported that CD44, a receptor fo
Externí odkaz:
https://doaj.org/article/11307a7e9bfa4127ae06c05d15f49d26
Autor:
Marta Larrayoz, Maria J. Garcia-Barchino, Jon Celay, Amaia Etxebeste, Maddalen Jimenez, Cristina Perez, Raquel Ordoñez, Cesar Cobaleda, Cirino Botta, Vicente Fresquet, Sergio Roa, Ibai Goicoechea, Catarina Maia, Miren Lasaga, Marta Chesi, P. Leif Bergsagel, Maria J. Larrayoz, Maria J. Calasanz, Elena Campos-Sanchez, Jorge Martinez-Cano, Carlos Panizo, Paula Rodriguez-Otero, Silvestre Vicent, Giovanna Roncador, Patricia Gonzalez, Satoru Takahashi, Samuel G. Katz, Loren D. Walensky, Shannon M. Ruppert, Elisabeth A. Lasater, Maria Amann, Teresa Lozano, Diana Llopiz, Pablo Sarobe, Juan J. Lasarte, Nuria Planell, David Gomez-Cabrero, Olga Kudryashova, Anna Kurilovich, Maria V. Revuelta, Leandro Cerchietti, Xabier Agirre, Jesus San Miguel, Bruno Paiva, Felipe Prosper, Jose A. Martinez-Climent
The historical lack of preclinical models reflecting the genetic heterogeneity of multiple myeloma (MM) hampers the advance of therapeutic discoveries. To circumvent this limitation, we screened mice engineered to carry eight MM lesions (NF-κB, KRAS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2563a745972cadf6c4af5126546113b9
https://hdl.handle.net/10171/65914
https://hdl.handle.net/10171/65914
Autor:
Semira Sheikh, Upen Patil, Kristin Wehrman, Elissavet Sideri, Shannon M. Ruppert, Yanke Yu, Mark Yan, Jasdeep Bhatti, Lydia Pogeza, Yann Nouet
Publikováno v:
Blood. 140:12640-12641
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2cf826afa3138b8df409c08079c4e85
https://doi.org/10.1182/blood-2022-157737
https://doi.org/10.1182/blood-2022-157737
Autor:
Irina Gurevich, Jayakumar Rajadas, Adam Frymoyer, Wenchao Sun, Andrey V. Malkovskiy, Jens W. Fischer, Gernot Kaber, Bryan J. Xie, Nadine Nagy, Paul L. Bollyky, Payton L. Marshall, Hedwich F. Kuipers, Maria Grandoch, Shannon M. Ruppert
Publikováno v:
J Biol Chem
4-Methylumbelliferone (4-MU) inhibits hyaluronan (HA) synthesis and is an approved drug used for managing biliary spasm. However, rapid and efficient glucuronidation is thought to limit its utility for systemically inhibiting HA synthesis. In particu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0568546a359e72c6469081d032833993
https://doi.org/10.1074/jbc.ra118.006166
https://doi.org/10.1074/jbc.ra118.006166
Autor:
Nadine Nagy, Gernot Kaber, Alberto Pugliese, Paul L. Bollyky, Jason J. Yang, S. Alice Long, Koshika Yadava, Hedwich F. Kuipers, Sarah C. Heilshorn, Shannon M. Ruppert, Michael J. Kratochvil
Interleukin 2 (IL-2) is a promising therapy for autoimmune type 1 diabetes (T1D), but the short half-life in vivo (less than 6 minutes) limits effective tissue exposure to IL-2. Tissue exposure is required for the tolerogenic effects of IL-2. We have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda6bee68f12fed03a117014966c8ddc
Autor:
Patrick R. Secor, Robert Manasherob, Swathi Balaji, Paul L. Bollyky, Sundeep G. Keswani, Koshika Yadava, Vivekananda Gupta Sunkari, Johanna M. Sweere, Michelle S. Bach, Chandan K. Sen, Heather D. Ishak, Shannon M. Ruppert
Objective: Our goal was to develop a chronic wound model in mice that avoids implantation of foreign material or impaired immunity and to use this to characterize the local and systemic immune response associated with Pseudomonas aeruginosa infection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::159b4c1aa09a90444315c59bb3013a3e
https://europepmc.org/articles/PMC6940591/
https://europepmc.org/articles/PMC6940591/
Autor:
Paul Hill, Kari C. Nadeau, Vinicio A. de Jesus Perez, Johanna M. Sweere, Swathi Balaji, Steven F. Ziegler, Ingrid A. Harten, Sundeep G. Keswani, William A. Altemeier, Ben A. Falk, Carlos Medina, Neil A. Fanger, John A. Gebe, Koshika Yadava, Manish J. Butte, Paul L. Bollyky, Gernot Kaber, Katalin Mikecz, Shannon M. Ruppert, Hongwei Han, Payton L. Marshall
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 56:109-120
The extracellular matrix in asthmatic lungs contains abundant low-molecular-weight hyaluronan, and this is known to promote antigen presentation and allergic responses. Conversely, high-molecular-weight hyaluronan (HMW-HA), typical of uninflamed tiss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fe847ddfd87d86facb7efb6d5897353
https://doi.org/10.1165/rcmb.2016-0111oc
https://doi.org/10.1165/rcmb.2016-0111oc
Publikováno v:
International Journal of Cell Biology, Vol 2015 (2015)
International Journal of Cell Biology
International Journal of Cell Biology
Cyclosporine A (CSA) is an immunosuppressive agent that specifically targets T cells and also increases the percentage of pro-tolerogenic CD4+Foxp3+ regulatory T cells (Treg) through unknown mechanisms. We previously reported that CD44, a receptor fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fb39c20a786007abb60708e3f973e9b
https://doi.org/10.1155/2015/614297
https://doi.org/10.1155/2015/614297