Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Shannon M. Lauberth"'
Autor:
Homa Rahnamoun, Hanbin Lu, Sascha H. Duttke, Christopher Benner, Christopher K. Glass, Shannon M. Lauberth
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Inflammation is known to affect cancer development, yet the mechanisms by which immune signaling drives transformation remain unclear. Here, the authors provide evidence that chronic TNF-α signaling promotes the enhancer binding and transcriptional
Externí odkaz:
https://doaj.org/article/afeca2176ca641f4a733a0cf6b0463bc
Autor:
Omar Bushara, James R. Wester, Danielle Jacobsen, Leyu Sun, Samuel Weinberg, Juehua Gao, Lawrence J. Jennings, Lu Wang, Shannon M. Lauberth, Feng Yue, Jie Liao, Guang-Yu Yang
Publikováno v:
Human Pathology. 131:9-16
With the advent of next-generation sequencing (NGS), identifying and better understanding genetic mutations in cancer pathways has become more feasible. A mutation now commonly reported in NGS panels is the SETD2 gene (H3K36 trimethyltransferase). Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e98b3b32f9b0bdcc9961d7b146736d2
https://doi.org/10.1016/j.humpath.2022.12.001
https://doi.org/10.1016/j.humpath.2022.12.001
Publikováno v:
Nature structural & molecular biology, vol 27, iss 6
Nat Struct Mol Biol
Nat Struct Mol Biol
Noncoding RNAs (ncRNAs) direct a remarkable number of diverse functions in development and disease through their regulation of transcription, RNA processing and translation. Leading the charge in the RNA revolution is a class of ncRNAs that are synth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e96760454f88942b0c982f6b8ae8766
https://doi.org/10.1038/s41594-020-0446-0
https://doi.org/10.1038/s41594-020-0446-0
Publikováno v:
Mol Cell
The past decade has revolutionized our understanding of regulatory noncoding RNAs (ncRNAs). Among the most recently identified ncRNAs are downstream-of-gene (DoG)-containing transcripts that are produced by widespread transcriptional readthrough. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea4a5d333e24c362a45754dd524e2919
https://europepmc.org/articles/PMC9208299/
https://europepmc.org/articles/PMC9208299/
Autor:
Omar Bushara, James Wester, Danielle Jacobsen, Leyu Sun, Samuel Weinberg, Lu Wang, Shannon M. Lauberth, Jie Liao, Guang-Yu Yang
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f496502a932c00f8cf562bbf6b4e9f63
https://doi.org/10.2139/ssrn.4247261
https://doi.org/10.2139/ssrn.4247261
Publikováno v:
Rahnamoun, H; Hong, J; Sun, Z; Lee, J; Lu, H; & Lauberth, SM. (2018). Mutant p53 regulates enhancer-associated H3K4 monomethylation through interactions with the methyltransferase MLL4. JOURNAL OF BIOLOGICAL CHEMISTRY, 293(34), 13234-13246. doi: 10.1074/jbc.RA118.003387. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/6jw4j08g
The Journal of biological chemistry, vol 293, iss 34
The Journal of biological chemistry, vol 293, iss 34
Monomethylation of histone H3 lysine 4 (H3K4me1) is enriched at enhancers that are primed for activation and the levels of this histone mark are frequently altered in various human cancers. Yet, how alterations in H3K4me1 are established and the cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::022c90bc1cee3c9d42e66e9c3bf50cf3
https://doi.org/10.1074/jbc.ra118.003387
https://doi.org/10.1074/jbc.ra118.003387
Autor:
Hanbin Lu, Christopher Benner, Homa Rahnamoun, Sascha H. Duttke, Christopher K. Glass, Shannon M. Lauberth
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature communications, vol 8, iss 1
Rahnamoun, H; Lu, H; Duttke, SH; Benner, C; Glass, CK; & Lauberth, SM. (2017). Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling. NATURE COMMUNICATIONS, 8. doi: 10.1038/s41467-017-01117-y. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/37h7q17n
Nature Communications
Nature communications, vol 8, iss 1
Rahnamoun, H; Lu, H; Duttke, SH; Benner, C; Glass, CK; & Lauberth, SM. (2017). Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling. NATURE COMMUNICATIONS, 8. doi: 10.1038/s41467-017-01117-y. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/37h7q17n
Nature Communications
Inflammation influences cancer development, progression, and the efficacy of cancer treatments, yet the mechanisms by which immune signaling drives alterations in the cancer cell transcriptome remain unclear. Using ChIP-seq, RNA-seq, and GRO-seq, her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681091c9c5705a5a615e95b219b297c2
https://doaj.org/article/afeca2176ca641f4a733a0cf6b0463bc
https://doaj.org/article/afeca2176ca641f4a733a0cf6b0463bc
Publikováno v:
Transcription
Since the discovery that enhancers can support transcription, the roles of enhancer RNAs have remained largely elusive. We identified that enhancer RNAs interact with and augment bromodomain engagement with acetylated chromatin. Here, we discuss our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a135ca59e9a6d528bbe0b1cd43093ab
https://pubmed.ncbi.nlm.nih.gov/31823686
https://pubmed.ncbi.nlm.nih.gov/31823686
Autor:
Zhengxi Sun, Homa Rahnamoun, Kristen M. Ramsey, Shannon M. Lauberth, Jihoon Lee, Elizabeth A. Komives, Hanbin Lu
Publikováno v:
Rahnamoun, Homa; Lee, Jihoon; Sun, Zhengxi; Lu, Hanbin; Ramsey, Kristen M; Komives, Elizabeth A; et al.(2018). RNAs interact with BRD4 to promote enhanced chromatin engagement and transcription activation.. Nature structural & molecular biology, 25(8), 687-697. doi: 10.1038/s41594-018-0102-0. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/0693t1gv
Nature structural & molecular biology, vol 25, iss 8
Nature structural & molecular biology, vol 25, iss 8
Bromodomain and extra-terminal motif (BET) protein BRD4 binds to acetylated histones at enhancers and promoters through its bromodomains (BDs) to regulate transcriptional elongation. Here, we reveal in human colorectal cancer cells that BRD4 is recru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c5bc7194656554847f65b47a781043
http://www.escholarship.org/uc/item/0693t1gv
http://www.escholarship.org/uc/item/0693t1gv
H3K4me3 Interactions with TAF3 Regulate Preinitiation Complex Assembly and Selective Gene Activation
Autor:
Shannon M. Lauberth, Andrea L. Ferris, Robert G. Roeder, Takahiro Nakayama, Zhanyun Tang, Xiaolin Wu, Stephen H. Hughes
Publikováno v:
Cell, vol 152, iss 5
Lauberth, SM; Nakayama, T; Wu, X; Ferris, AL; Tang, Z; Hughes, SH; et al.(2013). H3K4me3 interactions with TAF3 regulate preinitiation complex assembly and selective gene activation. Cell, 152(5), 1021-1036. doi: 10.1016/j.cell.2013.01.052. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/62n2t1s4
Lauberth, SM; Nakayama, T; Wu, X; Ferris, AL; Tang, Z; Hughes, SH; et al.(2013). H3K4me3 interactions with TAF3 regulate preinitiation complex assembly and selective gene activation. Cell, 152(5), 1021-1036. doi: 10.1016/j.cell.2013.01.052. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/62n2t1s4
Histone modifications regulate chromatin-dependent processes, yet the mechanisms by which they contribute to specific outcomes remain unclear. H3K4me3 is a prominent histone mark that is associated with active genes and promotes transcription through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f36857ee51c675dec2b7df7ae8082a5e
https://doi.org/10.1016/j.cell.2013.01.052
https://doi.org/10.1016/j.cell.2013.01.052