Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Shannon M. Grande"'
Autor:
Kristen E. Pauken, Jernej Godec, Pamela M. Odorizzi, Keturah E. Brown, Kathleen B. Yates, Shin Foong Ngiow, Kelly P. Burke, Seth Maleri, Shannon M. Grande, Loise M. Francisco, Mohammed-Alkhatim Ali, Sabrina Imam, Gordon J. Freeman, W. Nicholas Haining, E. John Wherry, Arlene H. Sharpe
Publikováno v:
Cell Reports, Vol 31, Iss 13, Pp 107827- (2020)
Summary: The PD-1 pathway regulates dysfunctional T cells in chronic infection and cancer, but the role of this pathway during acute infection remains less clear. Here, we demonstrate that PD-1 signals are needed for optimal memory. Mice deficient in
Externí odkaz:
https://doaj.org/article/8fdbfcfc91f44b0bbe20702e1a1824ab
Autor:
Seth Maleri, Keturah E. Brown, Sabrina Imam, Pamela M. Odorizzi, Shannon M. Grande, Arlene H. Sharpe, Kelly P. Burke, Kathleen B. Yates, Shin Foong Ngiow, E. John Wherry, Loise M. Francisco, Mohammed-Alkhatim Ali, Kristen E. Pauken, W. Nicholas Haining, Jernej Godec, Gordon J. Freeman
Publikováno v:
Cell Reports, Vol 31, Iss 13, Pp 107827-(2020)
Cell Rep
Cell Rep
Summary The PD-1 pathway regulates dysfunctional T cells in chronic infection and cancer, but the role of this pathway during acute infection remains less clear. Here, we demonstrate that PD-1 signals are needed for optimal memory. Mice deficient in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34da4c0988ea672f6ccc893045c30c46
https://doi.org/10.1016/j.celrep.2020.107827
https://doi.org/10.1016/j.celrep.2020.107827
Autor:
Catherine L, Tan, Michael J, Peluso, Jefte M, Drijvers, Camila M, Mera, Shannon M, Grande, Keturah E, Brown, Jernej, Godec, Gordon J, Freeman, Arlene H, Sharpe
Publikováno v:
Immunohorizons
CD160 promotes NK cell cytotoxicity and IFN-γ production, but the function of CD160 on CD8(+) T cells remains unclear with some studies supporting a coinhibitory role and others a costimulatory role. In this study, we demonstrate that CD160 has a co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d05cc89ba4cc6b348caad9272dd89afb
https://pubmed.ncbi.nlm.nih.gov/31022694
https://pubmed.ncbi.nlm.nih.gov/31022694
Publikováno v:
Future Oncology. 2:301-310
Cancer is thought to arise as a consequence of multiple insults to a cell. Mutations that lead to increased expression or activity of proto-oncogenes or decreased expression of tumor suppressors are common insults that have been identified to date. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a838e88772eba96f90f74c9f6af177c
https://doi.org/10.2217/14796694.2.2.301
https://doi.org/10.2217/14796694.2.2.301
Publikováno v:
Oncogene. 25:2748-2757
Immunoreceptor tyrosine-based activation motifs (ITAMs) are involved in the transduction of signals necessary for activation, differentiation, and survival in hematopoietic cells. Several viruses have been shown to encode ITAM-containing transmembran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92175dd1b806c08ede28444efc722fb8
https://doi.org/10.1038/sj.onc.1209296
https://doi.org/10.1038/sj.onc.1209296
Autor:
Elad Katz, Susan R. Ross, John C. Rassa, Shannon M. Grande, Jose Russo, John G. Monroe, Leslie B. King, Mohamed H. Lareef
Publikováno v:
The Journal of Experimental Medicine
Expression of immunoreceptor tyrosine-based activation motif (ITAM)-containing signaling proteins is normally restricted to hematopoietic tissues. The basal activity of ITAM-containing proteins is mediated through negative regulation by coreceptors r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d08c8568cbcb671514a13b990183889d
http://europepmc.org/articles/PMC2213037
http://europepmc.org/articles/PMC2213037
Publikováno v:
Journal of virology. 86(24)
Many receptors in hematopoietic cells use a common signaling pathway that relies on a highly conserved immunoreceptor tyrosine-based activation motif (ITAM), which signals through Src family tyrosine kinases. ITAM-bearing proteins are also found in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03bce25a321981703cc758c14de561b2
https://pubmed.ncbi.nlm.nih.gov/23015704
https://pubmed.ncbi.nlm.nih.gov/23015704
Publikováno v:
Immunological reviews. 218
The presence of an immunoreceptor tyrosine-based activation motif (ITAM) makes immunoreceptors different from other signaling receptors, like integrins, G-coupled protein receptors, chemokine receptors, and growth factor receptors. This unique motif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::285fbc81b47e2ceaaeda6d0acacf35e5
https://pubmed.ncbi.nlm.nih.gov/17624955
https://pubmed.ncbi.nlm.nih.gov/17624955
Autor:
Jennifer C. Paterson, Duonan Yu, Shannon M. Grande, John G. Monroe, Michael L. Atchison, Suchita Hodawadekar, Jan Erikson, Anna Azvolinsky, Andrei Thomas-Tikhonenko, Diana Cozma, John W. Tobias, Michele H. Metzgar, Teresa Marafioti
Publikováno v:
The Journal of clinical investigation. 117(9)
The presumed involvement of paired box gene 5 (PAX5) in B-lymphomagenesis is based largely on the discovery of Pax5-specific translocations and somatic hypermutations in non-Hodgkin lymphomas. Yet mechanistically, the contribution of Pax5 to neoplast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::484148e26a546b968966f6fe435f8251
https://pubmed.ncbi.nlm.nih.gov/17717600
https://pubmed.ncbi.nlm.nih.gov/17717600
Publikováno v:
The FASEB Journal. 22:400-400
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ba27253a7f2cb8ffae87f194d05f84b
https://doi.org/10.1096/fasebj.22.2_supplement.400
https://doi.org/10.1096/fasebj.22.2_supplement.400