Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Shannon M, Harlan"'
Publikováno v:
Molecular Metabolism, Vol 8, Iss , Pp 1-12 (2018)
Objectives: The autonomic nervous system is critically involved in mediating the control by leptin of many physiological processes. Here, we examined the role of the leptin receptor (LepR) in proopiomelanocortin (POMC) and agouti-related peptide (AgR
Externí odkaz:
https://doaj.org/article/2b6d78565eb54609a5197dc19284374c
Autor:
Josef G. Heuer, Raymond C. Harris, Shannon M Harlan, Jessica M. Overstreet, Matthew D. Breyer, Kathleen M. Heinz-Taheny
Publikováno v:
Toxicologic Pathology. 46:991-998
The ReninAAV db/db uNx model of diabetic kidney disease (DKD) exhibits hallmarks of advanced human disease, including progressive elevations in albuminuria and serum creatinine, loss of glomerular filtration rate, and pathological changes. Microarray
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::571525a2e18af81989566769bbc4804e
https://doi.org/10.1177/0192623318804986
https://doi.org/10.1177/0192623318804986
Publikováno v:
Molecular Metabolism, Vol 8, Iss, Pp 1-12 (2018)
Objectives: The autonomic nervous system is critically involved in mediating the control by leptin of many physiological processes. Here, we examined the role of the leptin receptor (LepR) in proopiomelanocortin (POMC) and agouti-related peptide (AgR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a847053a01e72541a888401d69ba40ec
http://www.sciencedirect.com/science/article/pii/S221287781730950X
http://www.sciencedirect.com/science/article/pii/S221287781730950X
Autor:
Hui-Rong Qian, Tao Wei, Josef G. Heuer, Kathleen M. Heinz-Taheny, Shannon M Harlan, Derek D. Yang, John Morris Sullivan, Jeffrey S. Boyles, Dianna L. Jaqua, Matthew D. Breyer, Derrick R. Witcher, Jonathan M. Wilson
Publikováno v:
American Journal of Physiology-Renal Physiology. 312:F951-F962
Transforming growth factor-alpha (TGFA) has been shown to play a role in experimental chronic kidney disease associated with nephron reduction, while its role in diabetic kidney disease (DKD) is unknown. We show here that intrarenal TGFA mRNA express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20b27ff6c3129951dd87e3467722c37a
https://doi.org/10.1152/ajprenal.00443.2016
https://doi.org/10.1152/ajprenal.00443.2016
Publikováno v:
Toxicologic pathology. 46(8)
Diabetes mellitus (types 1 and 2) is the leading cause of glomerular disease and end-stage renal disease in most developed countries, with estimates that one-third of people living with diabetes will develop diabetic kidney disease (DKD). The current
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c09fad6b9691b1286b9ffdb1a1b21172
https://pubmed.ncbi.nlm.nih.gov/30213245
https://pubmed.ncbi.nlm.nih.gov/30213245
Autor:
Matthew D. Breyer, Loudon D Yantis, Shannon M Harlan, Tamer Coskun, Josef G. Heuer, Robert A Ostroski
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 309:R467-R474
Mice provide a unique platform to dissect disease pathogenesis, with the availability of recombinant inbred strains and diverse genetically modified strains. Leveraging these reagents to elucidate the mechanisms of hypertensive tissue injury has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbf23c6e7f933356b428f39068a4dfb7
https://doi.org/10.1152/ajpregu.00106.2015
https://doi.org/10.1152/ajpregu.00106.2015
Autor:
Martin S. Cramer, Dianna L. Jaqua, Shannon M Harlan, Hana E. Baker, Tao Wei, Josef G. Heuer, John Morris Sullivan, Zhonghua Qi, Kathleen M. Heinz-Taheny, Tatiyana L. Shiyanova, Matthew D. Breyer
Publikováno v:
Journal of the American Society of Nephrology : JASN. 29(2)
Progress in research and developing therapeutics to prevent diabetic kidney disease (DKD) is limited by a lack of animal models exhibiting progressive kidney disease. Chronic hypertension, a driving factor of disease progression in human patients, is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e7a72d7cbfb08aef738890769df7105
https://pubmed.ncbi.nlm.nih.gov/29061652
https://pubmed.ncbi.nlm.nih.gov/29061652
Publikováno v:
Cell Metabolism. 17(4):599-606
SummaryThe fundamental importance of the hypothalamus in the regulation of autonomic and cardiovascular functions is well established. However, the molecular processes involved are not well understood. Here, we show that the mammalian (or mechanistic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b8a79085788a21280fabeeb2b9eae68
Publikováno v:
Molecular Metabolism. 14:158
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fb05ebba105f529b6c29a9417516c42
https://doi.org/10.1016/j.molmet.2018.05.018
https://doi.org/10.1016/j.molmet.2018.05.018
Autor:
Shannon M. Harlan, Sunju Choi, Jim J.-C. Lin, Jenny Li-Chun Lin, Qinchuan Wang, Haley W. Sinn, Elisabeth A. Gustafson-Wagner
Publikováno v:
Journal of Biological Chemistry. 282:36024-36036
Targeted deletion of mXinα results in cardiac hypertrophy and cardiomyopathy with conduction defects (Gustafson-Wagner, E., Sinn, H. W., Chen, Y.-L., Wang, D.-Z., Reiter, R. S., Lin, J. L.-C., Yang, B., Williamson, R. A., Chen, J. N., Lin, C.-I., an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ba1fd493c6e2f702afb6d9761233ed5
https://doi.org/10.1074/jbc.m707639200
https://doi.org/10.1074/jbc.m707639200