Zobrazeno 1 - 10
of 20 263
pro vyhledávání: '"Shannon L"'
Autor:
Alex Z. Kadhim, Ben Vanderkruk, Samantha Mar, Meixia Dan, Katarina Zosel, Eric E. Xu, Rachel J. Spencer, Shugo Sasaki, Xuanjin Cheng, Shannon L. J. Sproul, Thilo Speckmann, Cuilan Nian, Robyn Cullen, Rocky Shi, Dan S. Luciani, Bradford G. Hoffman, Stefan Taubert, Francis C. Lynn
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Mediator, a co-regulator complex required for RNA Polymerase II activity, interacts with tissue-specific transcription factors to regulate development and maintain homeostasis. We observe reduced Mediator subunit MED15 expression in endocrin
Externí odkaz:
https://doaj.org/article/a99eab33e6ef46a1bcc1575a5001e336
Autor:
Kwangsik Nho, Shannon L. Risacher, Liana G. Apostolova, Paula J. Bice, Jared R. Brosch, Rachael Deardorff, Kelley Faber, Martin R. Farlow, Tatiana Foroud, Sujuan Gao, Thea Rosewood, Jun Pyo Kim, Kelly Nudelman, Meichen Yu, Paul Aisen, Reisa Sperling, Basavaraj Hooli, Sergey Shcherbinin, Diana Svaldi, Clifford R. Jack, William J. Jagust, Susan Landau, Aparna Vasanthakumar, Jeffrey F. Waring, Vincent Doré, Simon M. Laws, Colin L. Masters, Tenielle Porter, Christopher C. Rowe, Victor L. Villemagne, Logan Dumitrescu, Timothy J. Hohman, Julia B. Libby, Elizabeth Mormino, Rachel F. Buckley, Keith Johnson, Hyun-Sik Yang, Ronald C. Petersen, Vijay K. Ramanan, Nilüfer Ertekin-Taner, Prashanthi Vemuri, Ann D. Cohen, Kang-Hsien Fan, M. Ilyas Kamboh, Oscar L. Lopez, David A. Bennett, Muhammad Ali, Tammie Benzinger, Carlos Cruchaga, Diana Hobbs, Philip L. De Jager, Masashi Fujita, Vaishnavi Jadhav, Bruce T. Lamb, Andy P. Tsai, Isabel Castanho, Jonathan Mill, Michael W. Weiner, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI), the Department of Defense Alzheimer’s Disease Neuroimaging Initiative (DoD-ADNI), the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Study (A4 Study) and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN), the Australian Imaging, Biomarker & Lifestyle Study (AIBL), Andrew J. Saykin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Determining the genetic architecture of Alzheimer’s disease pathologies can enhance mechanistic understanding and inform precision medicine strategies. Here, we perform a genome-wide association study of cortical tau quantified by positron
Externí odkaz:
https://doaj.org/article/534dba93d5bf4620975ce9a0f564baf7
Autor:
Adam M. Wright, Yu-Chien Wu, Ho-Ching Yang, Shannon L. Risacher, Andrew J. Saykin, Yunjie Tong, Qiuting Wen
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-12 (2024)
Abstract Background Cardiac pulsation propels blood through the cerebrovascular network to maintain cerebral homeostasis. The cerebrovascular network is uniquely surrounded by paravascular cerebrospinal fluid (pCSF), which plays a crucial role in was
Externí odkaz:
https://doaj.org/article/dd6915e075624a428a6dd64f508b45b2
Autor:
Shannon L. Hoffman, Paul Schmiedmayer, Aryaman S. Gala, Kevin B. Wilkins, Laura Parisi, Shreesh Karjagi, Aarushi S. Negi, Simon Revlock, Christopher Coriz, Jeremy Revlock, Vishnu Ravi, Helen Bronte-Stewart
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract People with Parkinson’s disease (PWP) face critical challenges, including lack of access to neurological care, inadequate measurement and communication of motor symptoms, and suboptimal medication management and compliance. We have develop
Externí odkaz:
https://doaj.org/article/4136cde6c1874815a3e7c5a1e43b2c1e
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Transplantation of stem cell-derived β-cells is a promising therapeutic advancement in the treatment of type 1 diabetes mellitus. A current limitation of this approach is the long differentiation timeline that generates a heterogeneous popu
Externí odkaz:
https://doaj.org/article/8a8150a1df314bc8a7de2e996dfba37b
Autor:
John D. Groarke, Jeffrey Crawford, Susie M. Collins, Shannon L. Lubaczewski, Danna M. Breen, Magdalena A. Harrington, Ira Jacobs, Ruolun Qiu, James Revkin, Michelle I. Rossulek, Aditi R. Saxena
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 3, Pp 1054-1061 (2024)
Abstract Background Cancer cachexia is a multifactorial metabolic wasting syndrome characterized by anorexia, unintentional loss of weight involving both skeletal muscle and adipose tissues, progressive functional impairment and reduced survival. The
Externí odkaz:
https://doaj.org/article/43771e5cd792467db7f7100408a7e000
Autor:
Christoph Königs, Shannon L. Meeks, Beatrice Nolan, Anja Schmidt, Malin Löfqvist, Jennifer Dumont, Lisa Leickt, Sushrusha Nayak, Stefan Lethagen
Publikováno v:
Therapeutic Advances in Hematology, Vol 15 (2024)
Background: Immune tolerance induction (ITI) is the gold standard for inhibitor eradication to restore the clinical efficacy of factor replacement therapy in haemophilia. However, as ITI often requires frequent administration over extended periods, i
Externí odkaz:
https://doaj.org/article/365a3c01fc194e33a031ea202a5cdf0f
Publikováno v:
Ecosphere, Vol 15, Iss 10, Pp n/a-n/a (2024)
Abstract Lyme disease, the most prevalent tick‐borne disease in North America, is caused by the bacterium Borrelia burgdorferi, and in the eastern and central United States, it is spread to humans by the black‐legged tick (Ixodes scapularis). Due
Externí odkaz:
https://doaj.org/article/bc213718913d416083274d3dc0751dea
Publikováno v:
Frontiers in Sleep, Vol 3 (2024)
IntroductionChildren and adolescents treated in specialty mental health services are more likely to have sleep disturbances than those without mental health problems. Few studies have investigated the relationship between sleep and psychopathology in
Externí odkaz:
https://doaj.org/article/13586dc111c2419197d28f87c8e8e870
Autor:
Kateryna Nabukhotna, Shannon L Kordus, John A Shupe, Rubén Cano Rodríguez, Anna Smith, Julia K Bohannon, M Kay Washington, D Borden Lacy
Publikováno v:
PLoS Pathogens, Vol 20, Iss 9, p e1012568 (2024)
Clostridioides difficile is a spore-forming pathogen and the most common cause of healthcare-associated diarrhea and colitis in the United States. Besides producing the main virulence factors, toxin A (TcdA) and toxin B (TcdB), many of the common cli
Externí odkaz:
https://doaj.org/article/e4b4bb5a738b4efeab523e61d2c2ba67