Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Shannon Kirejczyk"'
Autor:
Nanda Kishore Routhu, Narayanaiah Cheedarla, Venkata Satish Bollimpelli, Sailaja Gangadhara, Venkata Viswanadh Edara, Lilin Lai, Anusmita Sahoo, Ayalnesh Shiferaw, Tiffany M. Styles, Katharine Floyd, Stephanie Fischinger, Caroline Atyeo, Sally A. Shin, Sanjeev Gumber, Shannon Kirejczyk, Kenneth H. Dinnon, Pei-Yong Shi, Vineet D. Menachery, Mark Tomai, Christopher B. Fox, Galit Alter, Thomas H. Vanderford, Lisa Gralinski, Mehul S. Suthar, Rama Rao Amara
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Efficient vaccines for SARS-CoV-2 are needed. Here, the authors show that a trimeric form of the receptor-binding domain of SARS-CoV-2 spike adjuvanted with alum-3M-052 protects non-human primates from disease and inhibits infection.
Externí odkaz:
https://doaj.org/article/eb5e727593c442beadc6bb289092f047
Autor:
Timothy N. Hoang, Elise G. Viox, Amit A. Upadhyay, Zachary Strongin, Gregory K. Tharp, Maria Pino, Rayhane Nchioua, Maximilian Hirschenberger, Matthew Gagne, Kevin Nguyen, Justin L. Harper, Shir Marciano, Arun K. Boddapati, Kathryn L. Pellegrini, Jennifer Tisoncik-Go, Leanne S. Whitmore, Kirti A. Karunakaran, Melissa Roy, Shannon Kirejczyk, Elizabeth H. Curran, Chelsea Wallace, Jennifer S. Wood, Fawn Connor-Stroud, Sudhir P. Kasturi, Rebecca D. Levit, Michael Gale, Thomas H. Vanderford, Guido Silvestri, Kathleen Busman-Sahay, Jacob D. Estes, Monica Vaccari, Daniel C. Douek, Konstantin M.J. Sparrer, Frank Kirchhoff, R. Paul Johnson, Gideon Schreiber, Steven E. Bosinger, Mirko Paiardini
Type-I interferons (IFN-I) are critical mediators of innate control of viral infections, but also drive recruitment of inflammatory cells to sites of infection, a key feature of severe COVID-19. Here, and for the first time, IFN-I signaling was modul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98becb0535e8b6bb904a81ed8536fc97
https://doi.org/10.1101/2022.10.21.512606
https://doi.org/10.1101/2022.10.21.512606
Autor:
Olga Gonzalez, Sanjeev Gumber, Christopher Pinelli, Shyamesh Kumar, Edward J. Dick, Shannon Kirejczyk
Publikováno v:
Vet Pathol
Given their genetic and anatomic similarities to humans, nonhuman primates (NHPs) may serve as animal models for urogenital diseases of humans. The purpose of this study was to examine the frequency of spontaneous urogenital lesions occurring over a
Autor:
Mehul S. Suthar, Sailaja Gangadhara, Shannon Kirejczyk, Vineet D. Menachery, Narayanaiah Cheedarla, Venkata Viswanadh Edara, Sally Shin, Venkata S. Bollimpelli, Stephanie Fischinger, Katharine Floyd, Caroline Atyeo, Anusmita Sahoo, Pei Yong Shi, Kenneth H. Dinnon, Rama Rao Amara, Christopher B. Fox, Thomas H. Vanderford, Lilin Lai, Galit Alter, Lisa E. Gralinski, Tiffany M. Styles, Sanjeev Gumber, Ayalnesh Shiferaw, Mark A. Tomai, Nanda Kishore Routhu
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
There is a great need for the development of vaccines that induce potent and long-lasting protective immunity against SARS-CoV-2. Multimeric display of the antigen combined with potent adjuvant can enhance the potency and longevity of the antibody re
Autor:
Guido Ferrari, Neeta Shenvi, Thomas H. Vanderford, Susan Pereira Ribeiro, Wen-Hsiang Chen, David C. Montefiori, Talha Abid, Alessandro Sette, Daniela Weiskopf, Debashis Dutta, Katharine Floyd, Shelly Wang, Dieter Mielke, Sudhir Pai Kasturi, Georgia D. Tomaras, Pamela A. Kozlowski, Celia C. LaBranche, Maria Pino, Jungsoon Lee, Sherrie Jean, Venkata Viswanadh Edara, Xiaoying Shen, Justin Pollara, Justin C Smith, Mirko Paiardini, Rafick Pierre Sekaly, Fawn Connor-Stroud, Joyce Cohen, Gabriela Pacheco-Sanchez, Hongmei Gao, Zhuyun Liu, Christopher B. Fox, Sanjeev Gumber, Junfei Wei, Nathan Eisel, Maria Elena Bottazzi, Rachelle L. Stammen, Jennifer S. Wood, Shannon Kirejczyk, Bin Zhan, Muhammad Bilal Latif, Peter J. Hotez, Kirk Easley, Ulrich Strych, Jeroen Pollet, Mehul S. Suthar, Mark A. Tomai
Publikováno v:
Science immunology. 6(61)
Ongoing SARS-CoV-2 vaccine development is focused on identifying stable, cost-effective, and accessible candidates for global use, specifically in low and middle-income countries. Here, we report the efficacy of a rapidly scalable, novel yeast expres
Autor:
Shelly Wang, Steven E. Bosinger, Joyce Cohen, Sally Shin, Pei Yong Shi, Stephanie Fischinger, Fawn Connor-Stroud, Amit A. Upadhyay, Sailaja Gangadhara, Katharine Floyd, Sanjeev Gumber, Narayanaiah Cheedarla, Jennifer S. Wood, Mehul S. Suthar, Rama Rao Amara, Anusmita Sahoo, Ayalnesh Shiferaw, Nanda Kishore Routhu, Rachelle L. Stammen, Venkata Viswanadh Edara, David C. Montefiori, Vineet D. Menachery, Venkata S. Bollimpelli, Shannon Kirejczyk, Caroline Atyeo, Galit Alter, Thomas H. Vanderford, Lilin Lai, Sherrie Jean, Sheikh Abdul Rahman, Kathryn L. Pellegrini, Arun K. Boddapati
Publikováno v:
Immunity
A combination of vaccination approaches will likely be necessary to fully control the SARS-CoV-2 pandemic. Here, we show that modified vaccinia Ankara (MVA) vectors expressing membrane anchored pre-fusion stabilized spike (MVA/S), but not secreted S1
Autor:
Amit A. Upadhyay, Sudhir Pai Kasturi, Elise G. Viox, Steven E. Bosinger, Ernestine A. Mahar, Michael N. Sayegh, Sanjeev Gumber, Justin L. Harper, Arun K. Boddapati, Sijia Tao, Shelly Wang, Rebecca D. Levit, Thomas H. Vanderford, Michelle Y.H. Lee, Shannon Kirejczyk, Sherrie Jean, Keivan Zandi, Susan Pereira Ribeiro, Carly E. Starke, Lanfang Wang, Daniela Weiskopf, Maria Pino, Joyce Cohen, Timothy N. Hoang, Tristan R. Horton, Gregory K. Tharp, Jesse J. Waggoner, Kathleen Busman-Sahay, Anne Piantadosi, Olivia M. Delmas, Kathryn L. Pellegrini, Jennifer S. Wood, Jacob D. Estes, Peter D. Filev, Mirko Paiardini, Rachelle L. Stammen, Elizabeth N. Beagle, Zachary Strongin, Raymond F. Schinazi, Rafick Pierre Sekaly, Kimberly A. Cooney, Fawn Connor-Stroud, Hilmi Al Shakhshir
Publikováno v:
bioRxiv
Effective therapeutics aimed at mitigating COVID-19 symptoms are urgently needed. SARS-CoV-2 induced hypercytokinemia and systemic inflammation are associated with disease severity. Baricitinib, a clinically approved JAK1/2 inhibitor with potent anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb6f3ad475da4ad3af4b09b02cb47beb
https://doi.org/10.1101/2020.09.16.300277
https://doi.org/10.1101/2020.09.16.300277
Autor:
Zachary Strongin, Timothy N. Hoang, Rebecca D. Levit, Shelly Wang, Sherrie Jean, Kimberly A. Cooney, Susan Pereira Ribeiro, Mirko Paiardini, Lanfang Wang, Gregory K. Tharp, Rafick Pierre Sekaly, Michael Nekorchuk, Elise G. Viox, Raymond F. Schinazi, Justin L. Harper, Jacob D. Estes, Steven E. Bosinger, Michelle Y.H. Lee, Hilmi Al-Shakhshir, Rachelle L. Stammen, Kathleen Busman-Sahay, Arun K. Boddapati, Daniela Weiskopf, Sijia Tao, Anne Piantadosi, Guido Silvestri, Kathryn L. Pellegrini, Maria Pino, Michael N. Sayegh, Fawn Connor-Stroud, Thomas H. Vanderford, Tristan R. Horton, Jesse J. Waggoner, Joyce Cohen, Olivia M. Delmas, Jennifer S. Wood, Peter D. Filev, Carly E. Starke, Amit A. Upadhyay, Sudhir Pai Kasturi, Ernestine A. Mahar, Shannon Kirejczyk, Elizabeth N. Beagle, Sanjeev Gumber, Keivan Zandi
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
Cell
article-version (status) pre
article-version (number) 1
Cell
SARS-CoV-2 induced hypercytokinemia and inflammation are critically associated with COVID-19 disease severity. Baricitinib, a clinically approved JAK1/2 inhibitor, is currently being investigated in COVID-19 clinical trials. Here, we investigated the
Publikováno v:
Journal of the American Veterinary Medical Association. 251:897-900