Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Shannon K. Alford"'
Autor:
Douglas A. Lauffenburger, Kevin M. Haigis, Shannon K. Alford, Roli Mandhana, Pamela K. Kreeger
Supplementary Figures 1-7, Tables 1-8 from RAS Mutations Affect Tumor Necrosis Factor–Induced Apoptosis in Colon Carcinoma Cells via ERK-Modulatory Negative and Positive Feedback Circuits Along with Non-ERK Pathway Effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22164203158df948daf2d7e6e0dafb3b
https://doi.org/10.1158/0008-5472.22382999
https://doi.org/10.1158/0008-5472.22382999
Autor:
Douglas A. Lauffenburger, Kevin M. Haigis, Shannon K. Alford, Roli Mandhana, Pamela K. Kreeger
More than 40% of colon cancers have a mutation in K-RAS or N-RAS, GTPases that operate as central hubs for multiple key signaling pathways within the cell. Utilizing an isogenic panel of colon carcinoma cells with K-RAS or N-RAS variations, we observ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11d536e0cc8b982d8fcfb49775c54535
https://doi.org/10.1158/0008-5472.c.6500384
https://doi.org/10.1158/0008-5472.c.6500384
Autor:
Gregory D. Longmore, Hai Ngu, Shannon K. Alford, Frank C.P. Yin, Yunfeng Feng, Michael E. Ward
Publikováno v:
Experimental Cell Research. 319:1124-1135
In polarized, migrating cells, stress fibers are a highly dynamic network of contractile acto-myosin structures composed of bundles of actin filaments held together by actin cross-linking proteins such as α-actinins. As such, α-actinins influence a
Publikováno v:
Annals of Biomedical Engineering. 38:2775-2790
The ability to predict endothelial cell migration rates may aid in the design of biomaterials that endothelialize following implantation. However, the complexity of the signaling response to migration-promoting stimuli such as sphingosine 1-phosphate
Autor:
Kevin M. Haigis, Pamela K. Kreeger, Shannon K. Alford, Roli Mandhana, Douglas A. Lauffenburger
Publikováno v:
PubMed Central
More than 40% of colon cancers have a mutation in K-RAS or N-RAS, GTPases that operate as central hubs for multiple key signaling pathways within the cell. Utilizing an isogenic panel of colon carcinoma cells with K-RAS or N-RAS variations, we observ
Publikováno v:
Journal of Biomedical Materials Research Part A. :205-212
Sphingosine 1-phosphate (S1P) promotes endothelial cell migration in vitro and may potentially impact the endothelialization of implanted biomaterials. However, the effects of S1P on endothelial cells (EC) in flowing blood could be negligible due to
Publikováno v:
The Journal of Immunology. 181:2544-2555
Tissue homing of activated T cells is typically mediated through their specific integrin and chemokine receptor repertoire. Activation of human primary CD4+ T cells in the presence of CD46 cross-linking induces the development of a distinct immunomod
Autor:
Bradley K. Wacker, Evan A. Scott, Shannon K. Alford, Meghna Das Thakur, Gregory D. Longmore, Donald L. Elbert
Publikováno v:
Biophysical Journal. 94(1):273-285
Sphingosine 1-phosphate (S1P) is a potent chemokinetic agent for endothelial cells that is released by activated platelets. We previously developed Arg-Gly-Asp (RGD)-containing polyethylene glycol biomaterials for the controlled delivery of S1P to pr
Autor:
Robert Stobezki, Evanthia T. Roussos, Jeffrey B. Wyckoff, Jeffrey E. Segall, Maria Pozzuto, Anne R. Bresnick, Shannon K. Alford, Michele Balsamo, Sumanta Goswami, Frank B. Gertler, Douglas A. Lauffenburger, John S. Condeelis, Bojana Gligorijevic, Yarong Wang
Publikováno v:
Journal of cell science. 124(Pt 13)
We have shown previously that distinct Mena isoforms are expressed in invasive and migratory tumor cells in vivo and that the invasion isoform (MenaINV) potentiates carcinoma cell metastasis in murine models of breast cancer. However, the specific st
Publikováno v:
The FASEB Journal. 21