Výsledky vyhledávání - "Shannon G. Loelius"

Akademický článek

The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function

Autor: J. Allen Bennett, Michael A. Mastrangelo, Sara K. Ture, Charles O. Smith, Shannon G. Loelius, Rachel A. Berg, Xu Shi, Ryan M. Burke, Sherry L. Spinelli, Scott J. Cameron, Thomas E. Carey, Paul S. Brookes, Robert E. Gerszten, Maria Sabater-Lleal, Paul S. de Vries, Jennifer E. Huffman, Nicholas L. Smith, Craig N. Morrell, Charles J. Lowenstein

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)

Genetic association studies have identified loci including the choline transporter SLC44A2 as a potential regulator of thrombosis. Here the authors report that loss of SLC44A2 impairs platelet activation and thrombosis in mice via a reduction of mito

Externí odkaz: https://doaj.org/article/62b9f79769b2412ba271abefe8be6aa0

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Akademický článek

Blood product use for radiological/nuclear trauma: product development and US regulatory considerations

Autor: Toby A Silverman, Annette M Shadiack, Kimberly A Hofmeyer, Ashley E Cecere, Derek L Eisnor, Corey M Hoffman, Shannon G Loelius, Aditiben Patel, Mary J Homer

Publikováno v: Trauma Surgery & Acute Care Open, Vol 9, Iss Suppl 1 (2024)

Externí odkaz: https://doaj.org/article/de1effdc1c08462fb777ccfd7a3f78ed

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Interagency approaches to animal models for acute radiation exposure

Autor: Lisa S Carnell, Kasandra S Hunter, Mary J. Homer, Corey M Hoffman, Andrea L. DiCarlo, Shannon G Loelius

Publikováno v: International journal of radiation biology

Ionizing radiation can cause devastating injuries including hemorrhage, immune suppression, increased susceptibility to infection, and death. Medical countermeasures (MCMs) that address and mitigate radiation-induced injuries are the most important t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdeed5cfe8af1e929c76b46a47f99204
https://doi.org/10.1080/09553002.2021.2002661

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The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function

Autor: Paul S. de Vries, Sara Ture, Charles J. Lowenstein, Craig N. Morrell, J. Allen Bennett, Nicholas L. Smith, Sherry L. Spinelli, Ryan M. Burke, Xu Shi, Jennifer E. Huffman, Michael A. Mastrangelo, Robert E. Gerszten, Shannon G. Loelius, Charles O. Smith, Scott J. Cameron, Paul S. Brookes, Thomas E. Carey, Maria Sabater-Lleal, Rachel A. Berg

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
r-IIB SANT PAU: Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
Institut dInvestigació Biomèdica Sant Pau (IIB Sant Pau)

Genetic factors contribute to the risk of thrombotic diseases. Recent genome wide association studies have identified genetic loci including SLC44A2 which may regulate thrombosis. Here we show that Slc44a2 controls platelet activation and thrombosis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09d2be9ab822705a54b9078973bf7ed9
https://doi.org/10.1038/s41467-020-17254-w

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In Vitro and Ex Vivo Approaches to Evaluate Next-Generation Tobacco and Non-Tobacco Products on Human Blood Platelets

Autor: Shannon G. Loelius, Sherry L. Spinelli, Katie L. Lannan, Richard P. Phipps

Publikováno v: Applied in Vitro Toxicology

Human blood platelets are major hemostatic regulators in the circulation and important in the mediation of chronic inflammation and immunomodulation. They are key elements that promote cardiovascular pathogenesis that leads to atherosclerosis, thromb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7091afcb76791bf786619411426fcd5
http://europepmc.org/articles/PMC5338183

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The HIV protease inhibitor, ritonavir, dysregulates human platelet function in vitro

Autor: Sherry L. Spinelli, Shannon G. Loelius, Richard P. Phipps, Neil Blumberg, Katie L. Lannan

There are 37 million people globally infected with the Human Immunodeficiency Virus (HIV). People living with HIV can achieve nearly normal lifespans due to the use of antiretroviral drugs (ARVs). However, people living with HIV experience chronic in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72e772fc042ca5b4b29c10ed103a395a
https://europepmc.org/articles/PMC6174677/

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Antiretroviral drugs and tobacco smoke dysregulate human platelets: A novel investigation into the etiology of HIV co-morbid cardiovascular disease

Autor: Shannon G Loelius, Katie L Lannan, Ann E Casey, Sherry L Spinelli, Richard P Phipps

Publikováno v: The Journal of Immunology. 198:125.10-125.10

While antiretroviral drugs (ARVs) successfully suppress Human Immunodeficiency Virus (HIV), HIV-infected persons still have a shorter lifespan and are at higher risk of developing cardiovascular disease (CVD) compared to uninfected persons. CVD is th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da3b2d0268624fa3b276299047cc83ea
https://doi.org/10.4049/jimmunol.198.supp.125.10

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