Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Shannon E Rose"'
Autor:
Jeremy A Miller, Angela Guillozet-Bongaarts, Laura E Gibbons, Nadia Postupna, Anne Renz, Allison E Beller, Susan M Sunkin, Lydia Ng, Shannon E Rose, Kimberly A Smith, Aaron Szafer, Chris Barber, Darren Bertagnolli, Kristopher Bickley, Krissy Brouner, Shiella Caldejon, Mike Chapin, Mindy L Chua, Natalie M Coleman, Eiron Cudaback, Christine Cuhaciyan, Rachel A Dalley, Nick Dee, Tsega Desta, Tim A Dolbeare, Nadezhda I Dotson, Michael Fisher, Nathalie Gaudreault, Garrett Gee, Terri L Gilbert, Jeff Goldy, Fiona Griffin, Caroline Habel, Zeb Haradon, Nika Hejazinia, Leanne L Hellstern, Steve Horvath, Kim Howard, Robert Howard, Justin Johal, Nikolas L Jorstad, Samuel R Josephsen, Chihchau L Kuan, Florence Lai, Eric Lee, Felix Lee, Tracy Lemon, Xianwu Li, Desiree A Marshall, Jose Melchor, Shubhabrata Mukherjee, Julie Nyhus, Julie Pendergraft, Lydia Potekhina, Elizabeth Y Rha, Samantha Rice, David Rosen, Abharika Sapru, Aimee Schantz, Elaine Shen, Emily Sherfield, Shu Shi, Andy J Sodt, Nivretta Thatra, Michael Tieu, Angela M Wilson, Thomas J Montine, Eric B Larson, Amy Bernard, Paul K Crane, Richard G Ellenbogen, C Dirk Keene, Ed Lein
Publikováno v:
eLife, Vol 6 (2017)
As more people live longer, age-related neurodegenerative diseases are an increasingly important societal health issue. Treatments targeting specific pathologies such as amyloid beta in Alzheimer’s disease (AD) have not led to effective treatments,
Externí odkaz:
https://doaj.org/article/34f96814eec64ca19f44cf823cbe4aa1
Autor:
Lisa R Beutler, Kiara C Eldred, Albert Quintana, C Dirk Keene, Shannon E Rose, Nadia Postupna, Thomas J Montine, Richard D Palmiter
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e28168 (2011)
The striatum is composed predominantly of medium spiny neurons (MSNs) that integrate excitatory, glutamatergic inputs from the cortex and thalamus, and modulatory dopaminergic inputs from the ventral midbrain to influence behavior. Glutamatergic acti
Externí odkaz:
https://doaj.org/article/6ce94d41c7fd482c83518c89378c3290
Autor:
Shannon E. Rose, C. Andrew Williams, Dale W. Hailey, Swati Mishra, Amanda Kirkland, C. Dirk Keene, Gwenn A. Garden, Suman Jayadev, Jessica E. Young
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2024)
Abnormal endo-lysosomal morphology is an early cytopathological feature of Alzheimer’s disease (AD) and genome-wide association studies (GWAS) have implicated genes involved in the endo-lysosomal network (ELN) as conferring increased risk for devel
Externí odkaz:
https://doaj.org/article/c0d5d4add48d4fdfb47207c220cc7ff6
Autor:
Nadia Postupna, Shannon E. Rose, Laura E. Gibbons, Natalie M. Coleman, Leanne L. Hellstern, Kayla Ritchie, Angela M. Wilson, Eiron Cudaback, Xianwu Li, Erica J. Melief, Allison E. Beller, Jeremy A. Miller, Amber L. Nolan, Desiree A. Marshall, Rod Walker, Thomas J. Montine, Eric B. Larson, Paul K. Crane, Richard G. Ellenbogen, Edward S. Lein, Kristen Dams-O'Connor, C. Dirk Keene
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
The late neuropathological effects of traumatic brain injury have yet to be fully elucidated, particularly with respect to community-based cohorts. To contribute to this critical gap in knowledge, we designed a multimodal neuropathological study, int
Externí odkaz:
https://doaj.org/article/9d4ce0378ae94ea494bf39044a1146f3
Autor:
Katherine E. Prater, Kevin J. Green, Sainath Mamde, Wei Sun, Alexandra Cochoit, Carole L. Smith, Kenneth L. Chiou, Laura Heath, Shannon E. Rose, Jesse Wiley, C. Dirk Keene, Ronald Y. Kwon, Noah Snyder-Mackler, Elizabeth E. Blue, Benjamin Logsdon, Jessica E. Young, Ali Shojaie, Gwenn A. Garden, Suman Jayadev
Publikováno v:
Nature Aging.
Microglia, the innate immune cells of the brain, influence Alzheimer’s disease (AD) progression and are potential therapeutic targets. However, microglia exhibit diverse functions, the regulation of which is not fully understood, complicating thera
Autor:
Christopher Dirk Keene, Jessica E. Young, Daniel A. Nicholson, Allison Knupp, Gary X. D'Souza, Shannon E. Rose
Publikováno v:
J Neurosci Res
The development of safe and effective treatments for age-associated neurodegenerative disorders is an on-going challenge faced by the scientific field. Key to the development of such therapies is the appropriate selection of modeling systems in which
Autor:
Katherine E. Prater, Kevin J. Green, Sainath Mamde, Wei Sun, Alexandra Cochoit, Carole L. Smith, Kenneth L. Chiou, Laura Heath, Shannon E. Rose, Jesse Wiley, C. Dirk Keene, Ronald Y. Kwon, Noah Snyder-Mackler, Elizabeth E. Blue, Benjamin Logsdon, Jessica E. Young, Ali Shojaie, Gwenn A. Garden, Suman Jayadev
Microglia-mediated neuroinflammation is hypothesized to contribute to disease progression in neurodegenerative diseases such as Alzheimer9s Disease (AD). Microglia demonstrate heterogeneous states in health and disease, with proposed beneficial, harm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76e48b437eaa13a3bc68172777a9f8cc
https://doi.org/10.1101/2021.10.25.465802
https://doi.org/10.1101/2021.10.25.465802
Autor:
Eric B. Larson, Leanne L Hellstern, Shannon E. Rose, Laura E. Gibbons, Cecilia S Lee, Paul K. Crane, Caitlin S. Latimer, Adult Changes in Thought (Act) Study, C. Dirk Keene
Publikováno v:
Journal of Alzheimer's Disease. 68:647-655
Background The aging eye offers unique opportunities to study and understand the aging brain, in particular related to Alzheimer's disease (AD) and dementia. However, little is known about relationships between eye diseases and dementia-related neuro
Autor:
Adam S. Fleisher, Anupa Arora, Patricia Aldea, Anthony Intorcia, Angela M. Wilson, Lucia I. Sue, C. Dirk Keene, Abhinay D. Joshi, Matthew Flitter, Andrew Siderowf, Mark A. Mintun, Geidy E. Serrano, Natalie M Coleman, Ming Lu, Michael Navitsky, Michael J. Pontecorvo, Thomas G. Beach, Shannon E. Rose, Leanne L Hellstern, Ian Kennedy, Michael D. Devous, Thomas J. Montine
Publikováno v:
EJNMMI Research
EJNMMI Research, Vol 10, Iss 1, Pp 1-10 (2020)
EJNMMI Research, Vol 10, Iss 1, Pp 1-10 (2020)
Background The objective of this study was to make a quantitative comparison of flortaucipir PET retention with pathological tau and β-amyloid across a range of brain regions at autopsy. Methods Patients with dementia (two with clinical diagnosis of