Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Shannon D, Shields"'
Autor:
Martin Dery, Huifen Chen, Shannon D. Shields, Elisia Villemure, Robin Larouche-Gauthier, Rebecca M. Reese, Jack A. Terrett, Matthew Volgraf, Jun Chen, Steven Magnuson
Publikováno v:
ACS Med Chem Lett
[Image: see text] Transient receptor potential ankyrin 1 (TRPA1) antagonists have generated broad interest in the pharmaceutical industry for the treatment of both pain and asthma. Over the past decade, multiple antagonist classes have been reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::577568716436f8ad375243faf967e8af
https://doi.org/10.1021/acsmedchemlett.1c00305
https://doi.org/10.1021/acsmedchemlett.1c00305
Autor:
Jun Chen, Baihua Hu, Kevin M. Johnson, Kang-Jye Chou, Jack A. Terrett, Yunli Wang, Lea Constantineau-Forget, Steven Magnuson, Chantal Grand-Maître, Francis Beaumier, John Liu, Lorena Riol-Blanco, Shannon D. Shields, Yong Chen, Brian Safina, Martin Dery, Elisia Villemure, Claudio Sturino, Huifen Chen, Luce Lépissier, Matthew Volgraf, Alessia Balestrini, Xiumin Wu, Daniel G. Shore, Stuart Ward, Wyne P. Lee, David H. Hackos, Andrew Peter Cridland, Robin Larouche-Gauthier, Lionel Rouge, Stephane Ciblat, Aijun Lu, Matt Baumgardner, Justin Ly, Rebecca M. Reese, Alexis Rohou, Eric Suto, Juan Zhang, Hank La
Publikováno v:
Journal of Medicinal Chemistry. 64:3843-3869
Transient receptor potential ankyrin 1 (TRPA1) is a nonselective calcium-permeable ion channel highly expressed in the primary sensory neurons functioning as a polymodal sensor for exogenous and endogenous stimuli and has generated widespread interes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c17e5be6b310c8cbde93a6ecff3b6232
https://doi.org/10.1021/acs.jmedchem.0c02023
https://doi.org/10.1021/acs.jmedchem.0c02023
Autor:
Sultan Chowdhury, Christoph Martin Dehnhardt, Tao Sheng, Clint Young, Rainbow Kwan, Michael Scott Wilson, Jun Chen, Matthew Waldbrook, Dinah Misner, C. Lee Robinette, Rebecca M. Reese, Elaine Chang, Henry Verschoof, Tanja S. Zabka, Girish Bankar, Philippe Bergeron, Luis Sojo, Karen Nelkenbrecher, Daniel P. Sutherlin, Amy Kim, Ivan William Hemeon, Andrea Lindgren, Jae H. Chang, Alla Yurevna Zenova, Shaoyi Sun, Jonathan Maher, Shannon D. Shields, Jun Li, Daniel F. Ortwine, David H. Hackos, Zhiwei Xie, Thilo Focken, Charles J. Cohen, Richard T. Dean, Shannon Decker, Janette Mezeyova, Kuldip Khakh, Antonio G. DiPasquale, Chien-An Chen, Andrew D. White, Brian Safina, Jodie Pang, Qi Jia, Sophia Lin, Jean-Christophe Andrez, J. P. Johnson, Steven J. McKerrall
Publikováno v:
Journal of Medicinal Chemistry. 64:2953-2966
Nav1.7 is an extensively investigated target for pain with a strong genetic link in humans, yet in spite of this effort, it remains challenging to identify efficacious, selective, and safe inhibitors. Here, we disclose the discovery and preclinical p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a8a9431d81bf8ca2eed0fbbfbb36905
https://doi.org/10.1021/acs.jmedchem.1c00049
https://doi.org/10.1021/acs.jmedchem.1c00049
Autor:
Søren Warming, Lorena Riol-Blanco, Shannon D. Shields, Wyne P. Lee, David H. Hackos, Michelle Dourado, Keith R. Anderson, Rebecca M. Reese, Alessia Balestrini, Kimberly L. Stark, Eric Suto
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
The transient receptor potential (TRP) superfamily of ion channels has garnered significant attention by the pharmaceutical industry. In particular, TRP channels showing high levels of expression in sensory neurons such as TRPV1, TRPA1, and TRPM8, ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8f8f5bf529a1f99b921b19ca00a4b27
http://link.springer.com/article/10.1038/s41598-020-57936-5
http://link.springer.com/article/10.1038/s41598-020-57936-5
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119067 (2015)
Cerebellar symptoms significantly diminish quality of life in patients with multiple sclerosis (MS). We previously showed that sodium channel Nav1.8, although normally restricted to peripheral somatosensory neurons, is upregulated in the cerebellum i
Externí odkaz:
https://doaj.org/article/11909f56cf99455da3fe28457e89cbe2
Autor:
Jodie Pang, Lunbin Deng, Girish Bankar, Jun Chen, Sultan Chowdhury, William R Proctor, Philippe Bergeron, Jennifer Vogt, Daniel F. Ortwine, Daniel P. Sutherlin, Jian Payandeh, Lilia Schumann, Shannon D. Shields, Christoph Martin Dehnhardt, Jae H. Chang, David H. Hackos, Elisa Ballini, Teresa Nguyen, Pengfei Ji, Glauco Tarozzo, Charles J. Cohen, Antonio G. DiPasquale, Kwong Wah Lai, Jonathan Maher, Kuldip Khakh, Steven J. McKerrall, Tania Chernov-Rogan, Wenfeng Liu, Brian Safina, Sophia Lin, Abid Hasan, J. P. Johnson
Publikováno v:
Journal of Medicinal Chemistry. 62:4091-4109
Using structure- and ligand-based design principles, a novel series of piperidyl chromane arylsulfonamide Nav1.7 inhibitors was discovered. Early optimization focused on improvement of potency through refinement of the low energy ligand conformation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::824349f727cab11e6b607d5268a59967
https://doi.org/10.1021/acs.jmedchem.9b00141
https://doi.org/10.1021/acs.jmedchem.9b00141
Autor:
Brian S, Safina, Steven J, McKerrall, Shaoyi, Sun, Chien-An, Chen, Sultan, Chowdhury, Qi, Jia, Jun, Li, Alla Y, Zenova, Jean-Christophe, Andrez, Girish, Bankar, Philippe, Bergeron, Jae H, Chang, Elaine, Chang, Jun, Chen, Richard, Dean, Shannon M, Decker, Antonio, DiPasquale, Thilo, Focken, Ivan, Hemeon, Kuldip, Khakh, Amy, Kim, Rainbow, Kwan, Andrea, Lindgren, Sophia, Lin, Jonathan, Maher, Janette, Mezeyova, Dinah, Misner, Karen, Nelkenbrecher, Jodie, Pang, Rebecca, Reese, Shannon D, Shields, Luis, Sojo, Tao, Sheng, Henry, Verschoof, Matthew, Waldbrook, Michael S, Wilson, Zhiwei, Xie, Clint, Young, Tanja S, Zabka, David H, Hackos, Daniel F, Ortwine, Andrew D, White, J P, Johnson, C Lee, Robinette, Christoph M, Dehnhardt, Charles J, Cohen, Daniel P, Sutherlin
Publikováno v:
Journal of medicinal chemistry. 64(6)
Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d744b2a5894fa87236be1caf92c75b8b
https://pubmed.ncbi.nlm.nih.gov/33682420
https://pubmed.ncbi.nlm.nih.gov/33682420
Autor:
Jun Chen, Justin Elstrott, Lan Wang, Simon S. Gao, Richard A.D. Carano, Jose E. Heredia, Elisia Villemure, Daniel G. Shore, Wyne P. Lee, Bobby Brillantes, Joseph H. Lin, Liling Liu, David H. Hackos, Jens Kortmann, Matthew Volgraf, Daniel D. Bravo, Christine Tam, Lorena Riol-Blanco, Steven Magnuson, Lionel Rouge, Chris Bjornson, Baihua Hu, Tania Chernov-Rogan, Rebecca M. Reese, Christopher P. Arthur, Min Jung, Michelle Dourado, Xiumin Wu, Victory Joseph, Alberto Estevez, John Liu, Alvin Gogineni, Juan Zhang, Laurie Leong, Jian Payandeh, Vishal Verma, Shannon D. Shields, Han Ting Ding, Brian Safina, Alessia Balestrini, Yong Chen, Vineela D. Gandham, Eric Suto, Jianyong Wang, Justin Ly, Rebecca N. Bauer, Jonas Doerr, Alexis Rohou, Cary D. Austin, Jason A. Vander Heiden, Xiaoying Yang, Ryan L. Wong, Lucinda Tam, Liuxi Chen, Kathy Hötzel, Kai H. Barck, Merone Roose-Girma, Claudio Ciferri, Huifen Chen, Bianca M. Liederer
Publikováno v:
Journal of Experimental Medicine. 218
Despite the development of effective therapies, a substantial proportion of asthmatics continue to have uncontrolled symptoms, airflow limitation, and exacerbations. Transient receptor potential cation channel member A1 (TRPA1) agonists are elevated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7586a7b163f0274f73ff2d6634f422f1
https://doi.org/10.1084/jem.20201637
https://doi.org/10.1084/jem.20201637
Autor:
Bobby Brillantes, David H. Hackos, Chang Liu, Demi Maria Zabala Greiner, Lionel Rouge, Jie Zheng, Jian Payandeh, Tianbo Li, Shannon D. Shields, Jun Chen, Matthew Volgraf, Satoko Kakiuchi-Kiyota, Steve Magnuson, Simon Vu, Brian Safina, Rebecca M. Reese, Yu Patrick Shi, Huifen Chen, Tania Chernov-Rogan, Pawan Bir Kohli, Alexis Rohou, Jianyong Wang, Christine Tam, Kevin M. Johnson
Publikováno v:
Neuron, vol 109, iss 2
The TRPA1 ion channel is activated by electrophilic compounds through the covalent modification of intracellular cysteine residues. How non-covalent agonists activate the channel and whether covalent and non-covalent agonists elicit the same physiolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6daefc23efa2033713d1bd3205032a40
https://pubmed.ncbi.nlm.nih.gov/33476560
https://pubmed.ncbi.nlm.nih.gov/33476560
Autor:
Steven J, McKerrall, Teresa, Nguyen, Kwong Wah, Lai, Philippe, Bergeron, Lunbin, Deng, Antonio, DiPasquale, Jae H, Chang, Jun, Chen, Tania, Chernov-Rogan, David H, Hackos, Jonathan, Maher, Daniel F, Ortwine, Jodie, Pang, Jian, Payandeh, William R, Proctor, Shannon D, Shields, Jennifer, Vogt, Pengfei, Ji, Wenfeng, Liu, Elisa, Ballini, Lilia, Schumann, Glauco, Tarozzo, Girish, Bankar, Sultan, Chowdhury, Abid, Hasan, J P, Johnson, Kuldip, Khakh, Sophia, Lin, Charles J, Cohen, Christoph M, Dehnhardt, Brian S, Safina, Daniel P, Sutherlin
Publikováno v:
Journal of medicinal chemistry. 62(8)
Using structure- and ligand-based design principles, a novel series of piperidyl chromane arylsulfonamide Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::353b137470888081de078c0141a07409
https://pubmed.ncbi.nlm.nih.gov/30943032
https://pubmed.ncbi.nlm.nih.gov/30943032