Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Shannon Chi"'
Publikováno v:
Photodiagnosis and Photodynamic Therapy, Vol 50, Iss , Pp 104359- (2024)
Externí odkaz:
https://doaj.org/article/89dac82653174e5ca250a0e191a268c0
Autor:
Melissa Voth, Shannon Chisholm, Hannah Sollid, Chelsea Jones, Lorraine Smith-MacDonald, Suzette Brémault-Phillips
Publikováno v:
JMIR mHealth and uHealth, Vol 11, p e51609 (2023)
Externí odkaz:
https://doaj.org/article/04e37ca34fbf4c13ac98454588d46d99
Publikováno v:
Tetrahedron Letters. 44:3659-3662
The synthesis of the biologically relevant, 4-trifluoromethylpyrido[1,2-a]pyrimidin-2-one 7, is reported. Addition of substituted 2-aminopyridines 5 to activated alkynoates leads to the facile formation of a series of metabolically stable trifluorome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b726e75d62feb78c0c799031dc643933
https://doi.org/10.1016/s0040-4039(03)00700-7
https://doi.org/10.1016/s0040-4039(03)00700-7
Autor:
Shannon Chi, Clayton H. Heathcock
Publikováno v:
Organic Letters. 1:3-6
Preussomerins G and I (2 and 3) have been synthesized for the first time. The key reaction in the synthesis is a possibly biomimetic tautomerization reaction depicted in Scheme 3 and the foregoing graphic. The driving force for this interesting rearr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d94a3190127102d930ceffeea2d483ef
https://doi.org/10.1021/ol990020+
https://doi.org/10.1021/ol990020+
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:111-114
L-Indospicine (Ind), a natural product amino acid analog of L-arginine, was synthesized from L-glutamic acid 2 in nine steps and 29% overall yield. Ind was evaluated as an alternative substrate or inhibitor of two nitric oxide synthase (NOS) isozymes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::614fa5d45d8eea18cc1c3df294ea6f10
https://doi.org/10.1016/0960-894x(95)00569-f
https://doi.org/10.1016/0960-894x(95)00569-f
Publikováno v:
ChemInform. 27
L-Indospicine (Ind), a natural product amino acid analog of L-arginine, was synthesized from L-glutamic acid 2 in nine steps and 29% overall yield. Ind was evaluated as an alternative substrate or inhibitor of two nitric oxide synthase (NOS) isozymes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a55ee8655381cc3e27281606147f545
https://doi.org/10.1002/chin.199617204
https://doi.org/10.1002/chin.199617204
Autor:
Shannon Chi, Clayton H. Heathcock
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad4e7502bebd06db01928fcaa971a8ec
https://doi.org/10.1002/chin.199941259
https://doi.org/10.1002/chin.199941259
Autor:
Bruce Jaffee, Robert Bennett, Mattia Karen M, Swanee Jacutin-Porte, Gregory J. LaRosa, Shaowu Chen, Shannon Chi, Marty Hodge, Anthony J. Coyle, Geraldine C Harriman, Celeste Harrington, Douglas F. Burdi, Kenneth G. Carson, Jose-Angel Gonzalo, Vikram Kansra, Timothy D. Ocain, Zhan Shi, Wei Yin
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(11)
The identification, optimization, and structure-activity relationship (SAR) of small-molecule CCR4 antagonists is described. An initial screening hit with micromolar potency was identified that was optimized to sub-micromolar binding potency by enant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c31bab5a4f1f167d556b9ba2d66902
https://pubmed.ncbi.nlm.nih.gov/17395464
https://pubmed.ncbi.nlm.nih.gov/17395464
Autor:
Gregory J. LaRosa, Kenneth G. Carson, Chuang Lu, Roland Kolbeck, Shomir Ghosh, Sean Smith, Daniel Flynn, Priya Eddy, Tracy J. Jenkins, Geraldine C Harriman, Cheng Zhang, Jianping Guo, Hua Yang, Robert A. Horlick, Ukti Mani, Michael A. Patane, Bing Guan, Bruce Jaffee, Robert Bennett, Elder Amy M, Vinita Uttamsingh, Shannon Chi, Qing Ye
Publikováno v:
Journal of medicinal chemistry. 49(9)
Activation of CCR8 by its ligand CCL1 may play an important role in diseases such as asthma, multiple sclerosis, and cancer. The study of small molecule CCR8 antagonists will help establish the validation of these hypotheses. We report the design, sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edce635799a13b033875d4ecdea4ac2f
https://pubmed.ncbi.nlm.nih.gov/16640325
https://pubmed.ncbi.nlm.nih.gov/16640325
Autor:
Athiwat Hutchaleelaha, Jin-Chen Yu, Neill A. Giese, Shannon Chi, Julie Anne Heath, Robert M. Scarborough, Anjali Pandey, Mukund Mehrotra, Stanley J. Hollenbach
Publikováno v:
ChemInform. 36
4-[4-(N-Substituted-thio-carbamoyl)-1-piperazinyl]-6-methoxy-7-alkoxyamino-quinazoline derivatives such as 14 (CT53986) have been identified to be potent and selective inhibitors of the phosphorylation of PDGFR. SAR-investigations are described in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93920d973e997054362beb001464950c
https://doi.org/10.1002/chin.200503154
https://doi.org/10.1002/chin.200503154