Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Shannon Carskadon"'
Autor:
Nishat Manzar, Umar Khalid Khan, Ayush Goel, Shannon Carskadon, Nilesh Gupta, Nallasivam Palanisamy, Bushra Ateeq
Publikováno v:
iScience, Vol 27, Iss 3, Pp 108794- (2024)
Summary: Elevated serine peptidase inhibitor, Kazal type 1 (SPINK1) levels in ∼10%–25% of prostate cancer (PCa) patients associate with aggressive phenotype, for which there are limited treatment choices and dismal clinical outcomes. Using an int
Externí odkaz:
https://doaj.org/article/5d40cabf42f84a7eadd63960c7a922f4
Autor:
Fawzi Abu Rous, MD, Pin Li, PhD, Shannon Carskadon, MS, Sunny RK. Singh, MD, Rebecca Chacko, MD, Hassan Abushukair, BS, Shirish Gadgeel, MD, Nallasivam Palanisamy, PhD
Publikováno v:
JTO Clinical and Research Reports, Vol 4, Iss 4, Pp 100486- (2023)
Introduction: Amplification of 3q is the most common genetic alteration identified in squamous cell carcinoma of the lung (LUSC), with the most frequent amplified region being 3q26 to 3q28. Methods: In this analysis, we aim to describe the prognostic
Externí odkaz:
https://doaj.org/article/c7df366176e24c1d96b5f847e1251dcf
Autor:
Sakshi Goel, Vipul Bhatia, Sushmita Kundu, Tanay Biswas, Shannon Carskadon, Nilesh Gupta, Mohammad Asim, Colm Morrissey, Nallasivam Palanisamy, Bushra Ateeq
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Distal-less homeobox 1 (DLX1) is reported as a prostate cancer (PCa) diagnostic biomarker, but the mechanism for its upregulation in PCa is unclear. Here the authors show that ERG, AR and FOXA1 transcriptionally regulates DLX1 expression in PCa, and
Externí odkaz:
https://doaj.org/article/455b94e4205c4b25adcdd9e6f04d6ae9
Autor:
Ritika Tiwari, Nishat Manzar, Vipul Bhatia, Anjali Yadav, Mushtaq A. Nengroo, Dipak Datta, Shannon Carskadon, Nilesh Gupta, Michael Sigouros, Francesca Khani, Matti Poutanen, Amina Zoubeidi, Himisha Beltran, Nallasivam Palanisamy, Bushra Ateeq
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
SPINK1 upregulation is found in ~10–25% of prostate cancers. Here, they show that whilst SPINK1 is transcriptionally repressed by androgen receptor and its co-repressor REST, it is upregulated after androgen-deprivation therapy, which leads to neur
Externí odkaz:
https://doaj.org/article/ed56d705553641adb43a60033adc4409
Autor:
Balabhadrapatruni VSK Chakravarthi, Pavithra Dedigama-Arachchige, Shannon Carskadon, Shanker Kalyana Sundaram, Jia Li, Kuan-Han Hank Wu, Darshan Shimoga Chandrashekar, James O Peabody, Hans Stricker, Clara Hwang, Dhananjay A Chitale, Sean R Williamson, Nilesh S Gupta, Nora M Navone, Craig Rogers, Mani Menon, Sooryanarayana Varambally, Nallasivam Palanisamy
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 10, Pp 989-1002 (2019)
We present the functional characterization of a pseudogene associated recurrent gene fusion in prostate cancer. The fusion gene KLK4-KLKP1 is formed by the fusion of the protein coding gene KLK4 with the noncoding pseudogene KLKP1. Screening of a coh
Externí odkaz:
https://doaj.org/article/9cb7c1c1d0ee478f8e60a7e5a6160896
Autor:
Paul W. Harms, Alexandra C. Hristov, David S. Kim, Tobenna Anens, Michael J. Quist, Javed Siddiqui, Shannon Carskadon, Rohit Mehra, Douglas R. Fullen, Timothy M. Johnson, Arul M. Chinnaiyan, Nallasivam Palanisamy
Publikováno v:
Human Pathology: Case Reports, Vol 1, Iss 2, Pp 21-28 (2014)
Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase that promotes tumorigenesis by epigenetic repression of tumor suppressor genes. Although EZH2 is overexpressed in many malignancies, activating EZH2 mutations have been described predo
Externí odkaz:
https://doaj.org/article/e9ecae430a3044439c4aa2b2925e7ff5
Autor:
Irfan A. Asangani, Donita C. Brady, Matthew L. Freedman, Robert B. Den, Goutham Narla, Nallasivam Palanisamy, Daniel J. Lee, Lauren E. Schwartz, Javed Siddiqui, Mark M. Pomerantz, Sylvan C. Baca, Shannon Carskadon, Jessica M. Posimo, Erick Mitchell-Velasquez, Samuel Sander Effron, Priti Lal, Shweta Aras, Qu Deng, Ramakrishnan Natesan, Reyaz ur Rasool
Supplementary Figures S1-S12, Supplementary Table S1-3, supplementary methods and reference.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::428b1ea3328b07aa415fc411cd6fc9e5
https://doi.org/10.1158/2159-8290.22535924
https://doi.org/10.1158/2159-8290.22535924
Autor:
Irfan A. Asangani, Donita C. Brady, Matthew L. Freedman, Robert B. Den, Goutham Narla, Nallasivam Palanisamy, Daniel J. Lee, Lauren E. Schwartz, Javed Siddiqui, Mark M. Pomerantz, Sylvan C. Baca, Shannon Carskadon, Jessica M. Posimo, Erick Mitchell-Velasquez, Samuel Sander Effron, Priti Lal, Shweta Aras, Qu Deng, Ramakrishnan Natesan, Reyaz ur Rasool
Metastatic castration-resistant prostate cancer (CRPC) is a fatal disease, primarily resulting from the transcriptional addiction driven by androgen receptor (AR). First-line CRPC treatments typically target AR signaling, but are rapidly bypassed, re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fdbfe9bee4ee9a1af227f8fe379b406
https://doi.org/10.1158/2159-8290.c.6547985.v1
https://doi.org/10.1158/2159-8290.c.6547985.v1
Autor:
Paul W. Harms, Scott A. Tomlins, Christopher K. Bichakjian, Tasha M. Hughes, Scott A. McLean, Steven Hrycaj, Vincent T. Ma, Javed Siddiqui, Rajiv M. Patel, Douglas R. Fullen, May P. Chan, Jae Eun Choi, Josh N. Vo, Rahul Mannan, Daniel R. Rhodes, Nallasivam Palanisamy, Shannon Carskadon, Xiaoming Wang, Bryan Johnson, Lili Zhao, Kelly L. Harms
Supplementary Materials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c29bbbf8c271f15cb6d4040271aa104
https://doi.org/10.1158/1078-0432.22482855.v1
https://doi.org/10.1158/1078-0432.22482855.v1
Autor:
Arul M. Chinnaiyan, Rohit Mehra, Sudhanshu Shukla, Fengyun Su, Kelly L. Harms, Douglas R. Fullen, Alison B. Durham, Sylvia Zelenka-Wang, Rajiv M. Patel, Javed Siddiqui, Xuhong Cao, Shannon Carskadon, Nallasivam Palanisamy, Paul W. Harms, Lisha Wang
Representative microphotographs of samples showing different MCPyV RNA in situ hybridization (RNA-ISH) intensity (400X magnification)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ccb99898307e6d5b9fa984f43bb0637
https://doi.org/10.1158/1078-0432.22467446.v1
https://doi.org/10.1158/1078-0432.22467446.v1