Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Shannon Bevans"'
Autor:
Mateus R. Amorim, Xin Wang, O. Aung, Shannon Bevans-Fonti, Frederick Anokye-Danso, Caitlin Ribeiro, Joan Escobar, Carla Freire, Huy Pho, Olga Dergacheva, Luiz G.S. Branco, Rexford S. Ahima, David Mendelowitz, Vsevolod Y. Polotsky
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113512- (2023)
Summary: Mismatch between CO2 production (Vco2) and respiration underlies the pathogenesis of obesity hypoventilation. Leptin-mediated CNS pathways stimulate both metabolism and breathing, but interactions between these functions remain elusive. We h
Externí odkaz:
https://doaj.org/article/064f3471777a450ebee6538a74108129
Autor:
Chenjuan Gu, Jeff Loube, Rachel Lee, Shannon Bevans-Fonti, Tianshi David Wu, Jessica H. Barmine, Jonathan C. Jun, Meredith C. McCormack, Nadia N. Hansel, Wayne Mitzner, Vsevolod Y. Polotsky
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Obese asthma is a unique phenotype of asthma characterized by non-allergic airway hyperresponsiveness (AHR) and inflammation which responds poorly to standard asthma therapy. Metformin is an oral hypoglycemic drug with insulin-sensitizing and anti-in
Externí odkaz:
https://doaj.org/article/98b92a7e4cd04d30be08fba454357956
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-3 (2021)
Externí odkaz:
https://doaj.org/article/77a70a604ccf426098a2e423aa62b323
Autor:
Omar A Mesarwi, Mi-Kyung Shin, Shannon Bevans-Fonti, Christina Schlesinger, Janet Shaw, Vsevolod Y Polotsky
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168572 (2016)
BACKGROUND:Obstructive sleep apnea (OSA) is associated with the progression of non-alcoholic fatty liver disease (NAFLD) to steatohepatitis and fibrosis. This progression correlates with the severity of OSA-associated hypoxia. In mice with diet induc
Externí odkaz:
https://doaj.org/article/b48a3d2ffbe54976b4235f2a09ba57e6
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144725 (2015)
Obstructive sleep apnea is associated with high cardiovascular morbidity and mortality. Intermittent hypoxia of obstructive sleep apnea is implicated in the development and progression of insulin resistance and atherosclerosis, which have been attrib
Externí odkaz:
https://doaj.org/article/f9fdfc2d051f499e90a9615feb63eb20
Autor:
Mi-Kyung Shin, Luciano F Drager, Qiaoling Yao, Shannon Bevans-Fonti, Doo-Young Yoo, Jonathan C Jun, Susan Aja, Sanjay Bhanot, Vsevolod Y Polotsky
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46562 (2012)
Obesity is associated with tissue hypoxia and the up-regulation of hypoxia inducible factor 1 alpha (HIF-1α). Prior studies in transgenic mice have shown that HIF-1α plays a role in the metabolic dysfunction associated with obesity. Therefore, we h
Externí odkaz:
https://doaj.org/article/55a381094e89462b800c2ab00d27273a
Autor:
Mateus Ramos Amorim, Xin Wang, O Aung, Shannon Bevans-Fonti, Frederick Anokye-Danso, Joan Escobar, Carla Freire, Huy Pho, Olga Dergacheva, Luiz Branco, David Mendelowitz, Vsevolod Polotsky
Publikováno v:
Physiology. 38
Individuals with obesity hypoventilation syndrome (OHS) are unable to increase ventilation to match increased CO2 production (VCO2). Obstructive sleep apnea (OSA), defined by the closure of the upper airway during sleep, is present in 90% of OHS pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cdf54be22e81a7b98eb550b0aeeb2a8
https://doi.org/10.1152/physiol.2023.38.s1.5728822
https://doi.org/10.1152/physiol.2023.38.s1.5728822
Autor:
Mateus Amorim, Xin Wang, O Aung, Shannon Bevans-Fonti, Frederick Anokye-Danso, Joan Escobar, Carla Freire, Huy Pho, Olga Dergacheva, Luiz Branco, David Mendelowitz, Vsevolod Polotsky
Publikováno v:
SLEEP. 46:A18-A19
Introduction Individuals with obesity hypoventilation syndrome (OHS) are unable to increase ventilation to match increased CO2 production (VCO2). Obstructive sleep apnea (OSA), defined by the closure of the upper airway during sleep, is present in 90
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9648c0ac31d938cd40a8026a9dbf0092
https://doi.org/10.1093/sleep/zsad077.0040
https://doi.org/10.1093/sleep/zsad077.0040
Autor:
Mateus R. Amorim, Xin Wang, Huy Pho, Shannon Bevans‐Fonti, Frederick Anokye‐Danso, Joan Escobar, Olga Dergacheva, Luiz G. S. Branco, David Mendelowitz, Vsevolod Y. Polotsky
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b50e4d4b7f2edbc7eaea5d14579334d2
https://doi.org/10.1096/fasebj.2022.36.s1.r2522
https://doi.org/10.1096/fasebj.2022.36.s1.r2522
Autor:
Huy Pho, Alan R. Schwartz, Rexford S. Ahima, Haris Younas, Frederick Anokye-Danso, Thomaz Fleury-Curado, Slava Berger, Shannon Bevans-Fonti, Mi Kyung Shin, Lynn W. Enquist, Vsevolod Y. Polotsky, Jonathan C. Jun, David Mendelowitz
Publikováno v:
American Journal of Respiratory and Critical Care Medicine
Rationale: Leptin treats upper airway obstruction and alveolar hypoventilation in leptin-deficient ob/ob mice. However, obese humans and mice with diet-induced obesity (DIO) are resistant to leptin because of poor permeability of the blood–brain ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c51b2258cdb92c33cdaf6658d07af1b
https://doi.org/10.1164/rccm.201805-0879oc
https://doi.org/10.1164/rccm.201805-0879oc