Clinical-genomic determinants of immune checkpoint blockade response in head and neck squamous cell carcinoma

Autor: Cristina Valero, Mahdi Golkaram, Joris L. Vos, Bin Xu, Conall Fitzgerald, Mark Lee, Shannon Kaplan, Catherine Y. Han, Xin Pei, Reith Sarkar, Lillian A. Boe, Abhinav Pandey, Elizabeth S. Koh, Charlotte L. Zuur, David B. Solit, Traci Pawlowski, Li Liu, Alan L. Ho, Diego Chowell, Nadeem Riaz, Timothy A. Chan, Luc G.T. Morris

Publikováno v: The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)

BACKGROUND Recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC) is generally an incurable disease, with patients experiencing median survival of under 10 months and significant morbidity. While immune checkpoint blockade (I

Externí odkaz: https://doaj.org/article/a3ed24c58f7546a1a3e8b395d5a3c618

Genetic and microenvironmental intra-tumor heterogeneity impacts colorectal cancer evolution and metastatic development

Autor: Daniel Sobral, Marta Martins, Shannon Kaplan, Mahdi Golkaram, Michael Salmans, Nafeesa Khan, Raakhee Vijayaraghavan, Sandra Casimiro, Afonso Fernandes, Paula Borralho, Cristina Ferreira, Rui Pinto, Catarina Abreu, Ana Lúcia Costa, Shile Zhang, Traci Pawlowski, Jim Godsey, André Mansinho, Daniela Macedo, Soraia Lobo-Martins, Pedro Filipe, Rui Esteves, João Coutinho, Paulo Matos Costa, Afonso Ramires, Fernando Aldeia, António Quintela, Alex So, Li Liu, Ana Rita Grosso, Luis Costa

Publikováno v: Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)

The genetic and microenvironmental heterogeneity of colorectal cancer is analyzed using a prospective biobank of primary and metastatic tumor tissues to highlight features of intra-tumoral heterogeneity that favor tumor progression and metastasis.

Externí odkaz: https://doaj.org/article/521f8b4260d84b81a20a13cbf27320d4

Comprehensive Genomic Profiling of Cell-Free Circulating Tumor DNA Detects Response to Ribociclib Plus Letrozole in a Patient with Metastatic Breast Cancer

Autor: Catarina Silveira, Ana Carla Sousa, Patrícia Corredeira, Marta Martins, Ana Rita Sousa, Arnaud Da Cruz Paula, Pier Selenica, David N. Brown, Mahdi Golkaram, Shannon Kaplan, Shile Zhang, Li Liu, Britta Weigelt, Jorge S. Reis-Filho, Luís Costa, Maria Carmo-Fonseca

Publikováno v: Biomolecules, Vol 12, Iss 12, p 1818 (2022)

Analysis of cell-free circulating tumor DNA obtained by liquid biopsy is a non-invasive approach that may provide clinically actionable information when conventional tissue biopsy is inaccessible or infeasible. Here, we followed a patient with hormon

Externí odkaz: https://doaj.org/article/eec7765c7472407b92e9cbbf8f2dd3f9

HERVs establish a distinct molecular subtype in stage II/III colorectal cancer with poor outcome

Autor: Fernando Aldeia, Joyee Yao, Mahdi Golkaram, André Mansinho, Sandra Casimiro, Cristina Ferreira, Alex So, Ana Lúcia Costa, Aaron Wise, Cassandra Garbutt, Daniela Macedo, Catarina Abreu, Luis Costa, Pedro Filipe, Shannon Kaplan, Jim Godsey, Marta Martins, Traci Pawlowski, C. Alvim, Pedro Marques da Costa, Nafeesa Khan, Afonso Fernandes, Raakhee Vijayaraghavan, Paula Borralho, João Malaquias, Shile Zhang, Michael L. Salmans, Li Liu

Publikováno v: npj Genomic Medicine, Vol 6, Iss 1, Pp 1-11 (2021)
NPJ Genomic Medicine
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

© The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad6d11f53f78a861f7e5dae19c47782d
https://doaj.org/article/957481dcdc6e4e478acc8a847c3b62c1

Microsatellite instability testing and lynch syndrome screening for colorectal cancer patients through tumour sequencing

Autor: Shile Zhang, Shannon Kaplan, Fernando Aldeia, C. Garbutt, Mahdi Golkaram, André Mansinho, Li Liu, A. Quintela, C. Alvim, S. Casino, Daniela Macedo, Luis Costa, Afonso Fernandes, Cristina Ferreira, Adília Costa, Traci Pawlowski, Alex So, Marta Martins

Publikováno v: Annals of Oncology. 30:v574

Background Universal tumor screening for Lynch Syndrome (LS), which involves up to 6 sequential tests, is recommended by NCCN guidelines for all patients with colorectal cancer (CRC) at diagnosis. Microsatellite instability (MSI) testing is the first

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::211fefddffd115794084aa05e6ee48ba
https://doi.org/10.1093/annonc/mdz257.001