Výsledky vyhledávání - "Shannique Clarke"

Akademický článek

Racial disparities in breast cancer preclinical and clinical models

Autor: Shannique Clarke, Sheray N. Chin, Leah Dodds, Sophia H. L. George, Simone Badal

Publikováno v: Breast Cancer Research, Vol 24, Iss 1, Pp 1-9 (2022)

Abstract Breast cancer (BCa) has long been a health burden to women across the globe. However, the burden is not equally carried across races. Though the manifestation and behavior of BCa differs among racial groups, the racial representation of mode

Externí odkaz: https://doaj.org/article/28aab603badb49f1802a6b94e06678ea

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Data from Expanding the Prostate Cancer Cell Line Repertoire with ACRJ-PC28, an AR-negative Neuroendocrine Cell Line Derived From an African-Caribbean Patient

Prostate cancer cell lines from diverse backgrounds are important to addressing disparities in prostate cancer incidence and mortality rates among Black men. ACRJ-PC28 was developed from a transrectal needle biopsy and established via inactivation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28755a7c6b27cfd88953e56008961bce
https://doi.org/10.1158/2767-9764.c.6550983

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Supplemental table ST1: Sample collection and culture conditions from Expanding the Prostate Cancer Cell Line Repertoire with ACRJ-PC28, an AR-negative Neuroendocrine Cell Line Derived From an African-Caribbean Patient

In these prior attempts, culture conditions such as media, extra-cellular matrices and culture flasks were varied to determine the optimal culture conditions for generation of prostate cancer explants.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39e15e06bc4263c9149aae6ec59b3578
https://doi.org/10.1158/2767-9764.22545600.v1

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Supplemental Figure SF4: The cytotoxic effect of a Cannabis extract, THC_EX3 on the viability of ACRJ-CP28 and PC3 cell line. from Expanding the Prostate Cancer Cell Line Repertoire with ACRJ-PC28, an AR-negative Neuroendocrine Cell Line Derived From an African-Caribbean Patient

Cell viability was determined using the MTS assay and OD readings were taken a 409nm. Plots were generated in Microsoft Excel and each data point represents the average of three replicates. Experiments shown are representative of two independent expe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104c002ffd8b5b951d6a484b44f466a0
https://doi.org/10.1158/2767-9764.22545606

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Supplementary Table ST4 from Expanding the Prostate Cancer Cell Line Repertoire with ACRJ-PC28, an AR-negative Neuroendocrine Cell Line Derived From an African-Caribbean Patient

Data from RNA-Seq analysis. Noteworthy were the gene ontologies with a high proportion of expressed genes, such as the nuclear compartment (28%), extracellular exosome compartment (15%), regulation of transcription (8%), apoptotic process (3%) and ox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::294aab620a5c4f01b71272a922abeb54
https://doi.org/10.1158/2767-9764.22545594.v1

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Supplemental Figure SF1: STR profiling for ACRJ-PC28 cells. from Expanding the Prostate Cancer Cell Line Repertoire with ACRJ-PC28, an AR-negative Neuroendocrine Cell Line Derived From an African-Caribbean Patient

STR profile of ACRJ-PC28 generated by IDEXX using PC indicates the novelty of the cell line (A) as the cell line senctic profile was compared to the profiles of other cell lines in the DSMZ STR database and did not match anv other reported profiles h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d561eb219ab2ec0be454301fca18ac88
https://doi.org/10.1158/2767-9764.22545618.v1

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Supplemental Figure SF2: IHC staining on original patient tissue from which ACRJ-PC28 was derived. from Expanding the Prostate Cancer Cell Line Repertoire with ACRJ-PC28, an AR-negative Neuroendocrine Cell Line Derived From an African-Caribbean Patient

Tissue sample was obtained from a transrectal needle biopsy of the prostate gland of a patient with PSA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10b27a5ef5cb52eb21aeef38b5efef08
https://doi.org/10.1158/2767-9764.22545615.v1

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Supplemental Figure SF3: IHC staining on ACRJ-PC28 cells compared to positive controls. from Expanding the Prostate Cancer Cell Line Repertoire with ACRJ-PC28, an AR-negative Neuroendocrine Cell Line Derived From an African-Caribbean Patient

IHC staining on ACRJ-PC28 cells compared to positive controls.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55777a5266c721f09b735ca419827f15
https://doi.org/10.1158/2767-9764.22545612

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Expanding the prostate cancer cell line repertoire with ACRJ-PC28, an AR-negative neuroendocrine cell line derived from an African-Caribbean patient

Publikováno v: Cancer Res Commun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02fa516ba0b437c8cf4790ca0cff6684
https://europepmc.org/articles/PMC9836004/

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