Výsledky vyhledávání - "Shannah Boens"

Enhanced DNA-repair capacity and resistance to chemically induced carcinogenesis upon deletion of the phosphatase regulator NIPP1

Autor: Louise Van Wijk, Shannah Boens, Aleyde Van Eynde, Mathieu Bollen, Iris Verbinnen, Mónica Ferreira, Kathelijne Szekér

Publikováno v: Oncogenesis, Vol 9, Iss 3, Pp 1-8 (2020)
Oncogenesis

Nuclear Inhibitor of PP1 (NIPP1) is a conserved regulatory subunit of protein phosphatase PP1. The selective deletion of NIPP1 in mouse liver parenchymal cells or skin epidermal cells culminates in a late-onset hyperproliferation of a subset of resid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::493ff841b14cb79ca990df98fad9545a
http://link.springer.com/article/10.1038/s41389-020-0214-3

Zobrazit plný text záznamu

Plný text ve formátu HTML

The phosphatase regulator NIPP1 restrains chemokine-driven skin inflammation

Autor: Margareta Nikolic, Mathieu Bollen, Raphael Rouget, Marloes C. M. Jonkhout, Mónica Ferreira, Shannah Boens, Aleyde Van Eynde, Kifayathullah Liakath-Ali, Kathelijne Szekér, Susan M. Schlenner, Iris Verbinnen

Publikováno v: J Invest Dermatol

Nuclear inhibitor of protein phosphatase 1 (NIPP1) is a ubiquitously expressed nuclear protein that regulates functions of protein serine/threonine phosphatase-1 in cell proliferation and lineage specification. The role of NIPP1 in tissue homeostasis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72e3630612c4effcc8c41def4dcb0afe
https://lirias.kuleuven.be/handle/123456789/649048

Zobrazit plný text záznamu

Correction: MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells

Autor: Lijs Beke, Cenk Kig, Joannes T. M. Linders, Shannah Boens, An Boeckx, Erika van Heerde, Marc Parade, An De Bondt, Ilse Van den Wyngaert, Tarig Bashir, Souichi Ogata, Lieven Meerpoel, Aleyde Van Eynde, Christopher N. Johnson, Monique Beullens, Dirk Brehmer, Mathieu Bollen

Publikováno v: Bioscience Reports

Protein kinase MELK has oncogenic properties and is highly overexpressed in some tumors. In the present study, we show that a novel MELK inhibitor causes both the inhibition and degradation of MELK, culminating in replication stress and a senescence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::891938c6105848dc771495fd681f3c57
https://pubmed.ncbi.nlm.nih.gov/26431963

Zobrazit plný text záznamu

The protein phosphatase 1 regulator NIPP1 is essential for mammalian spermatogenesis

Autor: Kathelijne Szekér, Shannah Boens, Margarida Fardilha, Aleyde Van Eynde, Mónica Ferreira, Iris Verbinnen, Mathieu Bollen, Claudia Winkler

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

NIPP1 is one of the major nuclear interactors of protein phosphatase PP1. The deletion of NIPP1 in mice is early embryonic lethal, which has precluded functional studies in adult tissues. Hence, we have generated an inducible NIPP1 knockout model usi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26804ca7efc108066355a54a94c328aa
https://lirias.kuleuven.be/handle/123456789/615289

Zobrazit plný text záznamu

The selective inhibition of protein phosphatase-1 results in mitotic catastrophe and impaired tumor growth

Autor: Claudia Winkler, Aleyde Van Eynde, Bart Lesage, Ewald Heroes, Mathieu Bollen, Shannah Boens, Nele Van Dessel, Sofie De Munter, Monique Beullens

The serine/threonine protein phosphatase-1 (PP1) complex is a key regulator of the cell cycle. However, the redundancy of PP1 isoforms and the lack of specific inhibitors have hampered studies on the global role of PP1 in cell cycle progression in ve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad30086b324f06cff98ac0f9fed23017
https://lirias.kuleuven.be/handle/123456789/522925

Zobrazit plný text záznamu

TheArabidopsis thalianaCheckpoint Kinase WEE1 Protects against Premature Vascular Differentiation during Replication Stress

Autor: Anelia Iantcheva, Hilde Van den Daele, Sara Maes, Arp Schnittger, Annika K. Weimer, Gert Van Isterdael, Naoki Takahashi, Toon Cools, Lieven De Veylder, Shannah Boens

Publikováno v: PLANT CELL

A sessile lifestyle forces plants to respond promptly to factors that affect their genomic integrity. Therefore, plants have developed checkpoint mechanisms to arrest cell cycle progression upon the occurrence of DNA stress, allowing the DNA to be re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::468d396af16ae6b0ed8e4685fb148b5f
https://doi.org/10.1105/tpc.110.082768

Zobrazit plný text záznamu

MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells

Autor: Dirk Brehmer, Christopher N. Johnson, Souichi Ogata, An Boeckx, Erika van Heerde, Lieven Meerpoel, Monique Beullens, Cenk Kig, Marc Parade, Joannes T. M. Linders, Aleyde Van Eynde, Tarig Bashir, An De Bondt, Shannah Boens, Ilse Van den Wyngaert, Mathieu Bollen, Lijs Beke

Publikováno v: Bioscience Reports

Maternal embryonic leucine zipper kinase (MELK), a serine/threonine protein kinase, has oncogenic properties and is overexpressed in many cancer cells. The oncogenic function of MELK is attributed to its capacity to disable critical cell-cycle checkp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd0f3ce120f4ec7c6b7f3bddfa8c088e
https://doi.org/10.1042/bsr20150194

Zobrazit plný text záznamu

Brief Report: The Deletion of the Phosphatase Regulator NIPP1 Causes Progenitor Cell Expansion in the Adult Liver

Autor: Aleyde Van Eynde, Mathieu Bollen, Tania Roskams, Thomas Gevaert, Leo A. van Grunsven, Mónica Ferreira, Kathelijne Szekér, Iris Verbinnen, Stefaan Verhulst, Myriam Baes, Shannah Boens

Publikováno v: Stem cells (Dayton, Ohio). 34(8)

The Ppp1r8 gene encodes NIPP1, a nuclear interactor of protein phosphatase PP1. The deletion of NIPP1 is embryonic lethal at the gastrulation stage, which has hampered its functional characterization in adult tissues. Here, we describe the effects of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92b6101d1c775008996d3615eea615ca
https://pubmed.ncbi.nlm.nih.gov/27068806

Zobrazit plný text záznamu

Genome-wide promoter binding profiling of protein phosphatase-1 and its major nuclear targeting subunits

Autor: Iris Verbinnen, Toon Verheyen, Monique Beullens, Janina Görnemann, Mathieu Bollen, Shannah Boens, Aleyde Van Eynde

Publikováno v: Nucleic Acids Research

Protein phosphatase-1 (PP1) is a key regulator of transcription and is targeted to promoter regions via associated proteins. However, the chromatin binding sites of PP1 have never been studied in a systematic and genome-wide manner. Methylation-based

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5e0f7616af7b7d2bb14604184209510
https://pubmed.ncbi.nlm.nih.gov/25990731

Zobrazit plný text záznamu

Protein phosphatase PP1-NIPP1 activates mesenchymal genes in HeLa cells

Autor: Janina Görnemann, Bart Lesage, Claudia Winkler, Aleyde Van Eynde, Mathieu Bollen, Nele Van Dessel, Shannah Boens

Publikováno v: FEBS letters. 589(12)

The deletion of the protein phosphatase-1 (PP1) regulator known as Nuclear Inhibitor of PP1 (NIPP1) is embryonic lethal during gastrulation, hinting at a key role of PP1-NIPP1 in lineage specification. Consistent with this notion we show here that a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7844ce8e051b8cac5f18204c37ec8686
https://pubmed.ncbi.nlm.nih.gov/25907536

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání