Výsledky vyhledávání - "Shanna K Nifoussi"

Akademický článek

Thr 163 phosphorylation causes Mcl-1 stabilization when degradation is independent of the adjacent GSK3-targeted phosphodegron, promoting drug resistance in cancer.

Autor: Shanna K Nifoussi, Julie A Vrana, Aaron M Domina, Alfredo De Biasio, Jingang Gui, Mark A Gregory, Stephen R Hann, Ruth W Craig

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e47060 (2012)

The antiapoptotic Bcl-2 family member Mcl-1 is a PEST protein (containing sequences enriched in proline, glutamic acid, serine, and threonine) and is subject to rapid degradation via multiple pathways. Impaired degradation leading to the maintenance

Externí odkaz: https://doaj.org/article/44c4beca0b6b4370a1fa1cb8e3dadb1b

Zobrazit plný text záznamu

Selective Proteasomal Degradation of the B′β Subunit of Protein Phosphatase 2A by the E3 Ubiquitin Ligase Adaptor Kelch-like 15

Autor: Anne-Claude Gingras, Elizabeth A. Oberg, Stefan Strack, Shanna K. Nifoussi

Publikováno v: Journal of Biological Chemistry. 287:43378-43389

Protein phosphatase 2A (PP2A), a ubiquitous and pleiotropic regulator of intracellular signaling, is composed of a core dimer (AC) bound to a variable (B) regulatory subunit. PP2A is an enzyme family of dozens of heterotrimers with different subcellu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c1a5f380422ec24b6e159f497fb163
https://doi.org/10.1074/jbc.m112.420281

Zobrazit plný text záznamu

Inhibition of protein phosphatase 2A (PP2A) prevents Mcl-1 protein dephosphorylation at the Thr-163/Ser-159 phosphodegron, dramatically reducing expression in Mcl-1-amplified lymphoma cells

Autor: Deborah L. Ornstein, Shanna K. Nifoussi, Stefan Strack, Gary Kasof, Nora R. Ratcliffe, Ruth W. Craig

Publikováno v: The Journal of biological chemistry. 289(32)

Abundant, sustained expression of prosurvival Mcl-1 is an important determinant of viability and drug resistance in cancer cells. The Mcl-1 protein contains PEST sequences (enriched in proline, glutamic acid, serine, and threonine) and is normally su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e233c87bda2767c734799faaa5b0967b
https://pubmed.ncbi.nlm.nih.gov/24939844

Zobrazit plný text záznamu

Thr 163 phosphorylation causes Mcl-1 stabilization when degradation is independent of the adjacent GSK3-targeted phosphodegron, promoting drug resistance in cancer

Autor: Stephen R. Hann, Jingang Gui, Aaron M. Domina, Julie A. Vrana, Mark A. Gregory, Ruth W. Craig, Shanna K. Nifoussi, Alfredo De Biasio

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e47060 (2012)
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99894756be61468ccd88ce7c835bc7b2
http://europepmc.org/articles/PMC3467206?pdf=render

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání